{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:15:37Z","timestamp":1790964937905,"version":"4.1.0"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T00:00:00Z","timestamp":1646784000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Prader\u2013Willi syndrome (PWS) is a genetic disorder caused by the lack of expression of genes on the paternally inherited chromosome region 15q11.2-q13. It is a multisystem disorder that is characterized by severe hypotonia with poor suck and feeding difficulties in early infancy, followed in early childhood by excessive eating and gradual development of morbid obesity. The incidence of type 2 diabetes mellitus is high, particularly in obese patients. Non-alcoholic fatty liver disease has also been reported in some patients with PWS. Liver adenomatosis is a benign vascular lesion of the liver, defined by the presence of &amp;gt;10 adenomas, in the otherwise healthy liver parenchyma. We report the first case of a patient with PWS with severe obesity, type 2 diabetes mellitus, and non-alcoholic fatty liver who also developed liver adenomatosis, review the pediatric literature on liver adenomatosis, and discuss the potential underlying mechanisms.<\/jats:p>","DOI":"10.3389\/fendo.2022.826772","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T12:01:41Z","timestamp":1646827301000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Case Report: Hepatic Adenomatosis in a Patient With Prader\u2013Willi Syndrome"],"prefix":"10.3389","volume":"13","author":[{"given":"Hajar","family":"Dauleh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Soliman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basma","family":"Haris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Khalifa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor","family":"Al Khori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,3,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-021-01574-9","article-title":"Obesity in Prader-Willi Syndrome: Physiopathological Mechanisms, Nutritional and Pharmacological Approaches","volume":"44","author":"Muscogiuri","year":"2021","journal-title":"J Endocrinol Invest"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2009.10.004","article-title":"Metabolic Syndrome in Children With Prader-Willi Syndrome: The Effect of Obesity","volume":"21","author":"Brambilla","year":"2011","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2004.00392.x","article-title":"Insulin Resistance and Obesity-Related Factors in Prader-Willi Syndrome: Comparison With Obese Subjects","volume":"67","author":"Talebizadeh","year":"2005","journal-title":"Clin Genet"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1733","article-title":"The Metabolic Phenotype of Prader-Willi Syndrome (PWS) in Childhood: Heightened Insulin Sensitivity Relative to Body Mass Index","volume":"96","author":"Haqq","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.08.004","article-title":"Natural History of Liver Adenomatosis: A Long-Term Observational Study","volume":"71","author":"Barbier","year":"2019","journal-title":"J Hepatol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.sempedsurg.2020.150944","article-title":"Preface - Pediatric Hepatobiliary Surgery","volume":"29","author":"Davenport","year":"2020","journal-title":"Semin Pediatr Surg"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(85)90220-3","article-title":"Liver Adenomatosis. 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