{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:29:27Z","timestamp":1762432167580,"version":"3.41.2"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:00:00Z","timestamp":1646179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["NTUH 108-A141"],"award-info":[{"award-number":["NTUH 108-A141"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Primary aldosteronism (PA) is the most common type of secondary hypertension, and it is associated with a higher rate of cardiovascular complications. KCNJ5 somatic mutations have recently been identified in aldosterone-producing adenoma (APA), however their influence on vascular remodeling and injury is still unclear. The aim of this study was to investigate the association between KCNJ5 somatic mutation status and vascular status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 179 APA patients who had undergone adrenalectomy from a prospectively maintained database, of whom 99 had KCNJ5 somatic mutations. Preoperative clinical, biochemical and imaging data of abdominal CT, including abdominal aortic calcification (AAC) score, aortic diameter and wall thickness at levels of superior (SMA) and inferior (IMA) mesenteric arteries were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After propensity score matching for age, sex, body mass index, triglycerides and low-density lipoprotein, there were 48 patients in each KCNJ5 (+) and KCNJ5 (-) group. Mutation carriers had a lower AAC score (217.3 \u00b1 562.2 vs. 605.6 \u00b1 1359.1, P=0.018), higher aortic wall thickness (SMA level: 2.2 \u00b1 0.6 mm vs. 1.8 \u00b1 0.6 mm, P=0.006; IMA level: 2.4 \u00b1 0.6 mm vs. 1.8 \u00b1 0.7 mm, P&amp;lt;0.001) than non-carriers. In multivariate analysis, KCNJ5 mutations were independently associated with AAC score (P=0.014) and aortic wall thickness (SMA level: P&amp;lt;0.001; IMA level: P=0.004). After adrenalectomy, mutation carriers had less aortic wall thickness progression than non-carriers (\u0394thickness SMA: -0.1 \u00b1 0.8 mm vs. 0.9 \u00b1 0.6 mm, P=0.024; IMA: -0.1 \u00b1 0.6 mm vs. 0.8 \u00b1 0.7 mm, P=0.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>KCNJ5 mutation carriers had less calcification burden of the aorta, thickened aortic wall, and less wall thickness progression than non-carriers.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2022.830130","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T06:40:46Z","timestamp":1646203246000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["KCNJ5 Somatic Mutation Is Associated With Higher Aortic Wall Thickness and Less Calcification in Patients With Aldosterone-Producing Adenoma"],"prefix":"10.3389","volume":"13","author":[{"given":"Bo-Ching","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor Jing-Wei","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien-Ting","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Zheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Li","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Yao","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Hsuan","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Hung","family":"Chou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng-Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Che-Wei","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Wei","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vin-Cent","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Sheng","family":"Hung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin-Chen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen-Hung","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,3,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.059","article-title":"A Prospective Study of the Prevalence of Primary Aldosteronism in 1,125 Hypertensive Patients","volume":"48","author":"Rossi","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60834-X","article-title":"Prevalence of Primary Hyperaldosteronism in Resistant Hypertension: A Retrospective Observational Study","volume":"371","author":"Douma","year":"2008","journal-title":"Lancet"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30367-4","article-title":"Cardiometabolic Outcomes and Mortality in Medically Treated Primary Aldosteronism: A Retrospective Cohort Study","volume":"6","author":"Hundemer","year":"2018","journal-title":"Lancet Diabetes Endocrinol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.01.015","article-title":"Evidence for an Increased Rate of Cardiovascular Events in Patients With Primary Aldosteronism","volume":"45","author":"Milliez","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000039328.33137.6C","article-title":"Increased Carotid Wall Elastic Modulus and Fibronectin in Aldosterone-Salt-Treated Rats: Effects of Eplerenone","volume":"106","author":"Lacolley","year":"2002","journal-title":"Circulation"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2008.243","article-title":"Adrenalectomy improves arterial stiffness in primary aldosteronism","volume":"21","author":"Strauch","year":"2008","journal-title":"Am J Hypertens"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.12.003","article-title":"Adrenalectomy Improves Increased Carotid Intima-Media Thickness and Arterial Stiffness in Patients With Aldosterone Producing Adenoma","volume":"221","author":"Lin","year":"2012","journal-title":"Atherosclerosis"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/srep20862","article-title":"Time Course and Factors Predicting Arterial Stiffness Reversal in Patients With Aldosterone-Producing Adenoma After Adrenalectomy: Prospective Study of 102 Patients","volume":"6","author":"Liao","year":"2016","journal-title":"Sci Rep"},{"key":"B9","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1750-1172-5-9","article-title":"Aldosterone-Producing Adenoma and Other Surgically Correctable Forms of Primary Aldosteronism","volume":"5","author":"Amar","year":"2010","journal-title":"Orphanet J Rare Dis"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.03419","article-title":"Genetic Spectrum and Clinical Correlates of Somatic Mutations in Aldosterone-Producing Adenoma","volume":"64","author":"Fernandes-Rosa","year":"2014","journal-title":"Hypertension"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.186478","article-title":"Prevalence, Clinical, and Molecular Correlates of KCNJ5 Mutations in Primary Aldosteronism","volume":"59","author":"Boulkroun","year":"2012","journal-title":"Hypertension"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-2149","article-title":"A Meta-Analysis of Somatic KCNJ5 K(+) Channel Mutations In 1636 Patients With an Aldosterone-Producing Adenoma","volume":"100","author":"Lenzini","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/srep39121","article-title":"The Prevalence of CTNNB1 Mutations in Primary Aldosteronism and Consequences for Clinical Outcomes","volume":"7","author":"Wu","year":"2017","journal-title":"Sci Rep"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2885","article-title":"Expression and Mutations of KCNJ5 mRNA in Japanese Patients With Aldosterone-Producing Adenomas","volume":"97","author":"Taguchi","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.03346","article-title":"Clinical Characteristics of Somatic Mutations in Chinese Patients With Aldosterone-Producing Adenoma","volume":"65","author":"Zheng","year":"2015","journal-title":"Hypertension"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147590","article-title":"Genetics of Aldosterone-Producing Adenoma in Korean Patients","volume":"11","author":"Hong","year":"2016","journal-title":"PloS One"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2019-00531","article-title":"KCNJ5 Somatic Mutation Is a Predictor of Hypertension Remission After Adrenalectomy for Unilateral Primary Aldosteronism","volume":"104","author":"Vilela","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1097\/HJH.0000000000000186","article-title":"KCNJ5 Gene Somatic Mutations Affect Cardiac Remodelling But do Not Preclude Cure of High Blood Pressure and Regression of Left Ventricular Hypertrophy in Primary Aldosteronism","volume":"32","author":"Rossi","year":"2014","journal-title":"J Hypertens"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.15679","article-title":"KCNJ5 Somatic Mutations in Aldosterone-Producing Adenoma Are Associated With a Worse Baseline Status and Better Recovery of Left Ventricular Remodeling and Diastolic Function","volume":"77","author":"Chang","year":"2021","journal-title":"Hypertension"},{"key":"B20","doi-asserted-by":"publisher","first-page":"191","DOI":"10.5551\/jat.24455","article-title":"Comparison of Cardiovascular Complications in Patients With and Without KCNJ5 Gene Mutations Harboring Aldosterone-Producing Adenomas","volume":"22","author":"Kitamoto","year":"2015","journal-title":"J Atheroscler Thromb"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.10.079","article-title":"Long-Term Prognosis Associated With Coronary Calcification: Observations From a Registry of 25,253 Patients","volume":"49","author":"Budoff","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.628875","article-title":"Prediction of Clinical Cardiovascular Events With Carotid Intima-Media Thickness: A Systematic Review and Meta-Analysis","volume":"115","author":"Lorenz","year":"2007","journal-title":"Circulation"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.10.073","article-title":"Sex, Race, and Age Distributions of Mean Aortic Wall Thickness in a Multiethnic Population-Based Sample","volume":"53","author":"Rosero","year":"2011","journal-title":"J Vasc Surg"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.091827","article-title":"Comparison of the Captopril and the Saline Infusion Test for Excluding Aldosterone-Producing Adenoma","volume":"50","author":"Rossi","year":"2007","journal-title":"Hypertension"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2009.89","article-title":"Primary Aldosteronism: Diagnostic Accuracy of the Losartan and Captopril Tests","volume":"22","author":"Wu","year":"2009","journal-title":"Am J Hypertens"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(90)90282-T","article-title":"Quantification of Coronary Artery Calcium Using Ultrafast Computed Tomography","volume":"15","author":"Agatston","year":"1990","journal-title":"J Am Coll Cardiol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.186239","article-title":"Somatic Mutations Affecting the Selectivity Filter of KCNJ5 are Frequent in 2 Large Unselected Collections of Adrenal Aldosteronomas","volume":"59","author":"Azizan","year":"2012","journal-title":"Hypertension"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-019-0286-3","article-title":"Extracellular Matrix, Regional Heterogeneity of the Aorta, and Aortic Aneurysm","volume":"51","author":"Jana","year":"2019","journal-title":"Exp Mol Med"},{"key":"B29","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1098\/rsif.2005.0073","article-title":"Hyperelastic Modelling of Arterial Layers With Distributed Collagen Fibre Orientations","volume":"3","author":"Gasser","year":"2006","journal-title":"J R Soc Interface"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.173609","article-title":"Correlation Between Carotid Intimal\/Medial Thickness and Atherosclerosis: A Point of View From Pathology","volume":"30","author":"Finn","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90729-K","article-title":"Transesophageal Echocardiographically Detected Atherosclerotic Aortic Plaque Is a Marker for Coronary Artery Disease","volume":"21","author":"Fazio","year":"1993","journal-title":"J Am Coll Cardiol"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(94)90122-8","article-title":"Evaluation of Thoracic Aortic Atherosclerosis by Transesophageal Echocardiography","volume":"127","author":"Nishino","year":"1994","journal-title":"Am Heart J"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.37.2.787","article-title":"Mineralocorticoid Receptor Affects AP-1 and Nuclear Factor-Kappab Activation in Angiotensin II-Induced Cardiac Injury","volume":"37","author":"Fiebeler","year":"2001","journal-title":"Hypertension"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.174235","article-title":"Functional Mineralocorticoid Receptors in Human Vascular Endothelial Cells Regulate Intercellular Adhesion Molecule-1 Expression and Promote Leukocyte Adhesion","volume":"102","author":"Caprio","year":"2008","journal-title":"Circ Res"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000097769.47306.12","article-title":"Regulation of Superoxide Anion Production by NADPH Oxidase in Monocytes\/Macrophages: Contributions to Atherosclerosis","volume":"24","author":"Cathcart","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1161\/01.HYP.0000078357.92682.EC","article-title":"Endothelin Antagonism on Aldosterone-Induced Oxidative Stress and Vascular Remodeling","volume":"42","author":"Pu","year":"2003","journal-title":"Hypertension"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3281268532","article-title":"Increased Intima-Media Thickness of the Common Carotid Artery in Primary Aldosteronism in Comparison With Essential Hypertension","volume":"25","author":"Holaj","year":"2007","journal-title":"J Hypertens"},{"key":"B38","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1097\/HJH.0000000000000464","article-title":"Long-Term Effect of Specific Treatment of Primary Aldosteronism on Carotid Intima-Media Thickness","volume":"33","author":"Holaj","year":"2015","journal-title":"J Hypertens"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2011.04.041","article-title":"Treatment of Displaced Neck Fractures of the Femur With Total Hip Arthroplasty","volume":"27","author":"Rudelli","year":"2012","journal-title":"J Arthroplasty"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9035193","article-title":"The Strategy to Prevent and Regress the Vascular Calcification in Dialysis Patients","volume":"2017","author":"Chen","year":"2017","journal-title":"BioMed Res Int"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/srep11396","article-title":"Prevalence and Clinical Correlates of Somatic Mutation in Aldosterone Producing Adenoma-Taiwanese Population","volume":"5","author":"Wu","year":"2015","journal-title":"Sci Rep"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000002948","article-title":"Aldosterone-Producing Adenoma-Harbouring KCNJ5 Mutations Is Associated With Lower Prevalence of Metabolic Disorders and Abdominal Obesity","volume":"39","author":"Chen","year":"2021","journal-title":"J Hypertens"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00026.2015","article-title":"Primary Aldosteronism: Changing Definitions and New Concepts of Physiology and Pathophysiology Both Inside and Outside the Kidney","volume":"96","author":"Stowasser","year":"2016","journal-title":"Physiol Rev"},{"key":"B44","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1038\/ng.2550","article-title":"Somatic Mutations in ATP1A1 and ATP2B3 Lead to Aldosterone-Producing Adenomas and Secondary Hypertension","volume":"45","author":"Beuschlein","year":"2013","journal-title":"Nat Genet"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2716","article-title":"Somatic Mutations in ATP1A1 and CACNA1D Underlie a Common Subtype of Adrenal Hypertension","volume":"45","author":"Azizan","year":"2013","journal-title":"Nat Genet"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2695","article-title":"Somatic and Germline CACNA1D Calcium Channel Mutations in Aldosterone-Producing Adenomas and Primary Aldosteronism","volume":"45","author":"Scholl","year":"2013","journal-title":"Nat Genet"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1126\/science.1198785","article-title":"K+ Channel Mutations in Adrenal Aldosterone-Producing Adenomas and Hereditary Hypertension","volume":"331","author":"Choi","year":"2011","journal-title":"Science"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-1733","article-title":"Potassium Channel Mutant KCNJ5 T158A Expression in HAC-15 Cells Increases Aldosterone Synthesis","volume":"153","author":"Oki","year":"2012","journal-title":"Endocrinology"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-01004","article-title":"Targeted Molecular Characterization of Aldosterone-Producing Adenomas in White Americans","volume":"103","author":"Nanba","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.12070","article-title":"Genetic Characteristics of Aldosterone-Producing Adenomas in Blacks","volume":"73","author":"Nanba","year":"2019","journal-title":"Hypertension"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.14177","article-title":"Genetic, Cellular, and Molecular Heterogeneity in Adrenals With Aldosterone-Producing Adenoma","volume":"75","author":"De Sousa","year":"2020","journal-title":"Hypertension"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12873","article-title":"Novel Somatic Mutations in Primary Hyperaldosteronism are Related to the Clinical, Radiological and Pathological Phenotype","volume":"83","author":"Scholl","year":"2015","journal-title":"Clin Endocrinol (Oxf)"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.10111","article-title":"Old and New Concepts in the Molecular Pathogenesis of Primary Aldosteronism","volume":"70","author":"Prada","year":"2017","journal-title":"Hypertension"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-010-9581-8","article-title":"Assessment of Coronary Artery Calcium by Using Volumetric 320-Row Multi-Detector Computed Tomography: Comparison of 0.5 Mm With 3.0 Mm Slice Reconstructions","volume":"26","author":"van der Bijl","year":"2010","journal-title":"Int J Cardiovasc Imaging"},{"key":"B55","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s10554-011-9818-1","article-title":"Association of Abdominal Aortic Calcium With Coronary Artery Calcium and Obstructive Coronary Artery Disease: A Pilot Study","volume":"28","author":"Zweig","year":"2012","journal-title":"Int J Cardiovasc Imaging"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.830130\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T06:40:50Z","timestamp":1646203250000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.830130\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,2]]},"references-count":55,"alternative-id":["10.3389\/fendo.2022.830130"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2022.830130","relation":{},"ISSN":["1664-2392"],"issn-type":[{"type":"electronic","value":"1664-2392"}],"subject":[],"published":{"date-parts":[[2022,3,2]]},"article-number":"830130"}}