{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:29:16Z","timestamp":1792481356759,"version":"4.5.0"},"reference-count":19,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T00:00:00Z","timestamp":1647302400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Thyroid storm (TS) is a fatal disease that leads to multiple organ failure and requires prompt diagnosis. Diabetic ketoacidosis (DKA) is a trigger for thyroid crisis. However, TS and DKA rarely occur simultaneously. Moreover, owing to the rarity of the co-occurrence, the clinical course remains unclear. In this study, we present a case of TS that developed during the follow-up for repeated DKA in a young patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>A 25-year-old man with a history of recurrent DKA was brought to the emergency room frequently with similar symptoms. DKA treatment was initiated, but his tachycardia and disturbance of consciousness did not improve. Further examination of the patient revealed a Burch\u2013Wartofsky Point Scale score of 80 points, consistent with the Japan Thyroid Association criteria. Therefore, DKA coexisting with TS was diagnosed. Antithyroid medication, inorganic iodine, and corticosteroids were then started as treatment for TS, and \u03b2-blockers were administered to manage tachycardia. With these treatments, the patient\u2019s health improved and he recovered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In severe cases of recurrent DKA, the presence of TS should be considered, and early treatment should be initiated before the patient\u2019s condition worsens.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2022.834505","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T06:24:46Z","timestamp":1647325486000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Case Report: Occurrence of Thyroid Storm in a Young Patient With Recurrent Diabetic Ketoacidosis"],"prefix":"10.3389","volume":"13","author":[{"given":"Tatsuya","family":"Iino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Akatsuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuji","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,3,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1089\/thy.2017.0243","article-title":"Thyroid Storm: A Japanese Perspective","volume":"28","author":"Akamizu","year":"2018","journal-title":"Thyroid"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2011.0334","article-title":"Diagnostic Criteria, Clinical Features, and Incidence of Thyroid Storm Based on Nationwide Surveys","volume":"22","author":"Akamizu","year":"2012","journal-title":"Thyroid"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.4158\/EP14023.OR","article-title":"Clinical Characteristics and Outcome of Thyroid Storm: A Case Series and Review of Neuropsychiatric Derangements in Thyrotoxicosis","volume":"21","author":"Swee","year":"2015","journal-title":"Endocr Pract"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1177\/0885066613498053","article-title":"Thyroid Storm: An Updated Review","volume":"30","author":"Chiha","year":"2015","journal-title":"J Intensive Care Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1136\/pgmj.2006.049445","article-title":"Diabetic and Endocrine Emergencies","volume":"83","author":"Kearney","year":"2007","journal-title":"Postgrad Med J"},{"key":"B6","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/S0025-7125(16)30082-7","article-title":"Diabetic Ketoacidosis","volume":"79","author":"Kitabchi","year":"1995","journal-title":"Med Clin North Am"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-016587","article-title":"Incidence and Prevalence of Diabetic Ketoacidosis (DKA) Among Adults With Type 1 Diabetes Mellitus. 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