{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T07:43:35Z","timestamp":1787816615959,"version":"build-2784847793"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T00:00:00Z","timestamp":1650412800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003668","name":"Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003668","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>This study investigated the effects of a synbiotic combination (Syn) of <jats:italic>Lactobacillus gasseri<\/jats:italic> 505 (505) and <jats:italic>Cudrania tricuspidata<\/jats:italic> leaf extract (CT) on the hypothalamic-pituitary-gonadal axis in mice under chronic stress. Unpredictable chronic mild stress (UCMS) significantly increased the serum levels of corticosterone, however, treatment with Syn suppressed UCMS-induced increases. Histopathological analysis of the testes showed that these organs experienced some damage during UCMS, but this was repaired following treatment with Syn. Similarly, the transcription levels of gonadotropin-releasing hormone (<jats:italic>GnRH<\/jats:italic>), GnRH receptor, and gonadotropins, moreover, testicular development (i.e., <jats:italic>Adam5<\/jats:italic>, <jats:italic>Adam29<\/jats:italic>, and <jats:italic>Spam1<\/jats:italic>) - and steroidogenesis (i.e., <jats:italic>Lhr<\/jats:italic>, <jats:italic>Egfr<\/jats:italic>, and <jats:italic>StAR<\/jats:italic>) -related genes were significantly downregulated by UCMS. These UCMS-induced changes were inhibited by the administration of Syn, which was confirmed by the results of <jats:italic>in situ<\/jats:italic> hybridization analysis. These results suggest that the administration of Syn could attenuate the testicular dysfunctions induced by UCMS.<\/jats:p>","DOI":"10.3389\/fendo.2022.835033","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T11:55:30Z","timestamp":1650455730000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["A Synbiotic Combination of Lactobacillus gasseri 505 and Cudrania tricuspidata Leaf Extract Prevents Stress-Induced Testicular Dysfunction in Mice"],"prefix":"10.3389","volume":"13","author":[{"given":"Jae Yeon","family":"Joung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whasun","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeon 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