{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:51:23Z","timestamp":1753890683080,"version":"3.41.2"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T00:00:00Z","timestamp":1646870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study is to build a risk assessment system for central lymph node metastasis (CLNM) in papillary thyroid microcarcinoma (PTMC) of stage cN0 and to explore its application value in clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 500 patients with PTMC who underwent thyroid operation from 2013 to 2015 in Ningbo First Hospital were selected as the model group. Independent risk factors related to CLNM in PTMC were analyzed and determined, and a risk assessment system for CLNM was preliminarily established. Furthermore, the clinicopathological data from 328 PTMC patients with the same conditions as the model group from 2016 to 2017 were further collected as the validation group to verify the diagnostic value of the risk assessment system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The risk assessment system was based on the score rating (score \u2264 5 was classified as low risk, 6\u20138 was classified as medium risk, and \u22659 was classified as high-risk). The area under the receiver operating characteristic curve (ROC) was 0.687 (95% CI: 0.635\u20130.783). According to the risk assessment system, 328 PTMC patients in the validation group were scored. Among the low-risk group, the moderate-risk group, and the high-group, 96.8%, 58.1%, and 43.2% were the CLNM (-) patients, and 3.1%, 41.9%, and 65.8% were CLNM (+) patients, respectively. The area under ROC was 0.837 (95% CI: 0.778\u20130.869).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The risk assessment system in this study is of diagnostic value and can provide a theoretical foundation for intraoperative decision-making of prophylactic central neck dissection (pCND).<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2022.843573","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T12:44:30Z","timestamp":1646916270000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["The Application Value of the Central Lymph Node Metastasis Risk Assessment Model in Papillary Thyroid Microcarcinoma of Stage cN0: A Study of 828 Patients"],"prefix":"10.3389","volume":"13","author":[{"given":"Jinqiu","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianneng","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongping","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiabo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,3,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.18.2164","article-title":"Increasing Incidence of Thyroid Cancer in the United States, 1973-2002","volume":"295","author":"Davies","year":"2006","journal-title":"Jama"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2014.29.5.676","article-title":"Papillary Thyroid Microcarcinomas are Different From Latent Papillary Thyroid Carcinomas at Autopsy","volume":"29","author":"Lee","year":"2014","journal-title":"J Korean Med Sci"},{"key":"B3","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1089\/thy.2009.0045","article-title":"Utility of Contrast-Enhanced Ultrasound for Evaluation of Thyroid Nodules","volume":"20","author":"Zhang","year":"2010","journal-title":"Thyroid Off J Am Thyroid Assoc"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-002-6670-4","article-title":"Complications of Neck Dissection for Thyroid Cancer","volume":"26","author":"Cheah","year":"2002","journal-title":"World J Surg"},{"key":"B5","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1089\/thy.2012.0011","article-title":"Complications of Central Neck Dissection in Patients With Papillary Thyroid Carcinoma: Results of a Study on 1087 Patients and Review of the Literature","volume":"22","author":"Giordano","year":"2016","journal-title":"Thyroid Off J Am Thyroid Assoc"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.772071","article-title":"The Impact of Coexistent Hashimoto\u2019s Thyroiditis on Central Compartment Lymph Node Metastasis in Papillary Thyroid Carcinoma","volume":"12","author":"Liu","year":"2021","journal-title":"Front Endocrinol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0020","article-title":"2015 American Thyroid Association Management Guidelines for Adult Patients With Thyroid Nodules and Differentiated Thyroid Cancer: What is New and What has Changed","volume":"123","author":"Haugen","year":"2017","journal-title":"Cancer"},{"key":"B8","article-title":"Neck Node Dissection in Thyroid Cancer. 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