{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:45:10Z","timestamp":1791830710714,"version":"4.3.4"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T00:00:00Z","timestamp":1657238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"\n Objective<\/jats:title>\n Undercarboxylated osteocalcin (ucOC) is one form of osteocalcin lacking full carboxylation, which plays an important role in bone homeostasis, glucose homeostasis, and energy metabolism. Our aim is to obtain the profile of serum ucOC level according to gender and age and explore its associations with bone mineral density (BMD), bone turnover markers (BTMs), and prevalence of osteopenia and osteoporosis in the Chinese population.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This is a cross-sectional study with 900 subjects, composed of 431 men and 469 women. Clinical information was collected, and BMD values of the lumbar spine (L1\u20134), left femoral neck, and total hip were scanned. Biochemical markers including hepatic and renal function, serum calcium, serum phosphorus, procollagen type 1 N-propeptide (P1NP) \u03b2-CrossLaps of type I collagen-containing cross-linked C-telopeptide (\u03b2-CTX) intact parathyroid hormone (PTH), 25-hydroxyvitamin D (25OHD), and ucOC were measured.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We found that the median ucOC level was higher in men than women [men, 2.6 ng\/ml; women, 1.6 ng\/ml;\n p<\/jats:italic>\n &lt; 0.001]. The profile according to age showed that ucOC levels were the lowest at the age of 40\u201349 years in both men [2.55 ng\/ml (95% CI = 1.96\u20133.13 ng\/ml)] and women [1.57 ng\/ml (95% CI = 1.12\u20132.03 ng\/ml)]; in patients younger than 49 years, they decreased with age; then over 50 years, they quickly increased. Furthermore, we found that a higher ucOC level was correlated with lower BMD values at the lumbar spine (men, r = \u22120.128,\n p<\/jats:italic>\n = 0.013; women, r = \u22120.321,\n p<\/jats:italic>\n &lt; 0.001), femoral neck (men, r = \u22120.095,\n p<\/jats:italic>\n = 0.062; women, r = \u22120.260,\n p<\/jats:italic>\n &lt; 0.001), and total hip (men, r = \u22120.123,\n p<\/jats:italic>\n = 0.015; women, r = \u22120.209,\n p<\/jats:italic>\n &lt; 0.001) and higher P1NP (men, r = 0.307,\n p<\/jats:italic>\n &lt; 0.001; women, r = 0.239,\n p<\/jats:italic>\n &lt; 0.001) and \u03b2-CTX (men, r = 0.169,\n p<\/jats:italic>\n = 0.001; women, r = 0.354,\n p<\/jats:italic>\n &lt; 0.001) levels in both men and women. Furthermore, we also showed that a 1 \u2212 SD increase in ucOC was associated with an odds ratio (OR) of 1.63 and 1.70 for having osteopenia or osteoporosis in men and women, respectively (men, 95% CI = 1.25\u20132.13,\n p<\/jats:italic>\n = 0.004; women, 95% CI = 1.19\u20132.42,\n p<\/jats:italic>\n = 0.004).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n We first revealed the profile of serum ucOC levels according to gender and age in the Chinese population and demonstrated the associations of ucOC with BMD and BTMs and the risk of prevalent osteopenia or osteoporosis. Our findings provide a clue to elucidate the function of ucOC in bone metabolism.<\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fendo.2022.843912","type":"journal-article","created":{"date-parts":[[2022,7,10]],"date-time":"2022-07-10T17:51:45Z","timestamp":1657475505000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":26,"title":["Undercarboxylated Osteocalcin and Its Associations With Bone Mineral Density, Bone Turnover Markers, and Prevalence of Osteopenia and Osteoporosis in Chinese Population: A Cross-Sectional Study"],"prefix":"10.3389","volume":"13","author":[{"given":"Yang","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianyong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenlin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1513724","article-title":"Clinical Practice. 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