{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:22:29Z","timestamp":1793380949242,"version":"4.5.0"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In adults, gut dysbiosis may contribute to the pathogenesis of gout. However, the characteristics of gut microbiota in children with hyperuricemia (HUA) in the absence of clinical gout have not been explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This present study analyzed the gut microbiota in children with HUA as compared to controls (Con) and explored bacterial associations that may account for\u00a0differences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 80 children were enrolled in this study; they were divided into HUA and Con according to the level of serum uric acid (UA). The composition of gut microbiota was investigated by 16S rRNA high-throughput sequencing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Principal coordinate analysis revealed that gut microbiota of the HUA group was clustered together and separated partly from the Con group. There was no difference in alpha-diversity between the two groups. However, Spearman\u2019s correlation analysis revealed that serum UA level positively correlated with genera\n                      <jats:italic>Actinomyces, Morganella<\/jats:italic>\n                      , and\n                      <jats:italic>Streptococcus<\/jats:italic>\n                      , and negatively associated with the producers of short-chain fatty acids (SCFAs), such as\n                      <jats:italic>Alistipes, Faecalibacterium<\/jats:italic>\n                      , and\n                      <jats:italic>Oscillospira<\/jats:italic>\n                      , and the sulfidogenic bacteria\n                      <jats:italic>Bilophila.<\/jats:italic>\n                      The members of the genera\n                      <jats:italic>Alistipes<\/jats:italic>\n                      and\n                      <jats:italic>Bilophila<\/jats:italic>\n                      in the Con group were significantly more prevalent than the HUA subjects. Compared to the Con cohort, metabolic pathway predictions found that the superpathways of purine nucleotide\n                      <jats:italic>de novo<\/jats:italic>\n                      biosynthesis were decreased in HUA subjects, whereas the superpathway of purine deoxyribonucleoside de\tgradation was increased.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The composition of the gut microbiota in children with HUA differs from Con. Although causality cannot be established, modification in the microbiota that produces SCFA and sulfide may promote HUA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2022.848715","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T03:14:58Z","timestamp":1651029298000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":33,"title":["Altered Gut Microbiota in Children With 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