{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T05:33:07Z","timestamp":1778218387864,"version":"3.51.4"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T00:00:00Z","timestamp":1647561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Cardiovascular disease (CVD) is still the leading cause of death worldwide. Despite successful advances in both pharmacological and lifestyle strategies to fight well-established risk factors, the burden of CVD is still increasing. Therefore, it is necessary to further deepen our knowledge of the pathogenesis of the disease for developing novel therapies to limit even more its related morbidity and mortality. Oxidative stress has been identified as a common trait of several manifestations of CVD and could be a promising target for innovative treatments. Mitochondria are a major source of oxidative stress and sirtuins are a family of enzymes that generate different post-translational protein modifications, thus regulating important cellular processes, including cell cycle, autophagy, gene expression, and others. In particular, three sirtuins, SIRT3, SIRT4, and SIRT5 are located within the mitochondrial matrix where they regulate energy production and antioxidant pathways. Therefore, these sirtuins are strongly involved in the balance between oxidant and antioxidant mechanisms. In this review, we summarize the activities of these sirtuins with a special focus on their role in the control of oxidative stress, in relation to energy metabolism, atherosclerosis, and CVD.<\/jats:p>","DOI":"10.3389\/fendo.2022.858330","type":"journal-article","created":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T06:57:20Z","timestamp":1647586640000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["Redox Homeostasis in Cardiovascular Disease: The Role of Mitochondrial Sirtuins"],"prefix":"10.3389","volume":"13","author":[{"given":"Alberto","family":"Zullo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Guida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosaria","family":"Sciarrillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco P.","family":"Mancini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,3,18]]},"reference":[{"key":"B1","unstructured":"Cardiovascular Diseases (CVDs)"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/nu11092090","article-title":"Oxidative Stress in Cardiovascular Diseases: Still a Therapeutic Target","volume":"11","author":"Senoner","year":"2019","journal-title":"Nutrients"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/J.FREERADBIOMED.2013.02.011","article-title":"Reactive Oxygen Species and the Free Radical Theory of Aging","volume":"60","author":"Liochev","year":"2013","journal-title":"Free Radic Biol Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11010-019-03667-9","article-title":"ROS and Diseases: Role in Metabolism and Energy Supply","volume":"467","author":"Yang","year":"2020","journal-title":"Mol Cell Biochem"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/J.BBABIO.2010.01.004","article-title":"Mitochondrial Energy Metabolism and Ageing","volume":"1797","author":"Bratic","year":"2010","journal-title":"Biochim Biophys Acta - Bioenerg"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/NRM3801","article-title":"Cellular Mechanisms and Physiological Consequences of Redox-Dependent Signalling","volume":"15","author":"Holmstr\u00f6m","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00040.2012","article-title":"Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases","volume":"94","author":"Bhattacharyya","year":"2014","journal-title":"Physiol Rev"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELL.2005.02.001","article-title":"Mitochondria, Oxidants, and Aging","volume":"120","author":"Balaban","year":"2005","journal-title":"Cell"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.05.035","article-title":"Impact of Oxidative Stress on the Heart and Vasculature: Part 2 of a 3-Part Series","volume":"70","author":"M\u00fcnzel","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv290","article-title":"Protective Effects of Sirtuins in Cardiovascular Diseases: From Bench to Bedside","volume":"36","author":"Winnik","year":"2015","journal-title":"Eur Heart J"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/antiox9090858","article-title":"Sirt1\/sirt3 Modulates Redox Homeostasis During Ischemia\/Reperfusion in the Aging Heart","volume":"9","author":"Zhang","year":"2020","journal-title":"Antioxidants"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66378-7","article-title":"The Metabolic Syndrome","volume":"365","author":"Eckel","year":"2005","journal-title":"Lancet (Lond Engl)"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00238-0","article-title":"Atherosclerosis. 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