{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T19:48:36Z","timestamp":1785008916930,"version":"3.55.0"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:00:00Z","timestamp":1658707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>The duration of ovarian stimulation which is largely dependent on the ovarian response to hormonal stimulation may influence <jats:italic>in vitro<\/jats:italic> fertilization (IVF) outcomes. Menstrual cycle length is potentially a good indicator of ovarian reserve and can predict ovarian response. Ovarian stimulation and the follicular phase of the menstrual cycle are both processes of follicular development. There is no published research to predict the duration of ovarian stimulation based on the length of the menstrual cycle. Our retrospective cohort study included 6110 women with regular menstrual cycles who underwent their first IVF treatment between January 2015 and October 2020. Cycles were classified according to quartiles of the ratio of ovarian stimulation duration to original follicular phase length (OS\/FP). Multivariate generalized linear models were applied to assess the association between OS\/FP and IVF outcomes. The odds ratio (OR) or relative risk (RR) was estimated for each quartile with the lowest quartile as the comparison group. OS\/FP of 0.67 to 0.77 had more retrieved and mature oocytes (adjusted RR 1.11, 95% confidence interval [CI] 1.07\u20131.15, p for trend = 0.001; adjusted RR 1.14, 95% CI 1.09\u20131.19, p for trend = 0.001). OS\/FP of 0.67 to 0.77 showed the highest rate of fertilization (adjusted OR 1.11, 95% CI 1.05\u20131.17, p for trend = 0.001). OS\/FP &amp;gt; 0.77 had the lowest rate of high-quality blastocyst formation (adjusted OR 0.81, 95% CI 0.71\u20130.93, p for trend = 0.01). No apparent association was noted between OS\/FP and clinical pregnancy, live birth, or early miscarriage rate. In conclusion, OS\/FP has a significant effect on the number of oocytes, fertilization rate, and high-quality blastocyst formation rate. MCL could be used to predict the duration of ovarian stimulation with an OS\/FP of 0.67 to 0.77, which provides a new indicator for the individualized clinical optimization of the trigger time.<\/jats:p>","DOI":"10.3389\/fendo.2022.862500","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T09:22:23Z","timestamp":1658827343000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Association Between the Ratio of Ovarian Stimulation Duration to Original Follicular Phase Length and In Vitro Fertilization Outcomes: A Novel Index to Optimise Clinical Trigger Time"],"prefix":"10.3389","volume":"13","author":[{"given":"Xinyang","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jichun","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.06.004","article-title":"Menstruation: Science and Society","volume":"223","author":"Critchley","year":"2020","journal-title":"Am J Obstet Gynecol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1071\u201380","DOI":"10.1093\/oxfordjournals.aje.a009401","article-title":"Use of Urine Biomarkers to Evaluate Menstrual Function in Healthy Premenopausal Women","volume":"147","author":"Waller","year":"1998","journal-title":"Am J Epidemiol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.11.022","article-title":"Prospective Evaluation of Luteal Phase Length and Natural Fertility","volume":"107","author":"Crawford","year":"2017","journal-title":"Fertil Steril"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh188","article-title":"Factors Affecting Menstrual Cycle Characteristics","volume":"160","author":"Liu","year":"2004","journal-title":"Am J Epidemiol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/s41746-019-0152-7","article-title":"Real-World Menstrual Cycle Characteristics of More Than 600,000 Menstrual Cycles","volume":"2","author":"Bull","year":"2019","journal-title":"NPJ Digit Med"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.08.023","article-title":"Introduction: Contemporary Approaches to Alternative Ovarian Stimulation Strategies for In Vitro Fertilization","volume":"108","author":"Paulson","year":"2017","journal-title":"Fertil Steril"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2017.01.012","article-title":"A Randomized Controlled Trial Investigating the Use of a Predictive Nomogram for the Selection of the FSH Starting Dose in IVF\/ICSI Cycles","volume":"34","author":"Allegra","year":"2017","journal-title":"Reprod BioMed Online"},{"key":"B8","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.fertnstert.2016.10.033","article-title":"Individualized Versus Conventional Ovarian Stimulation for In Vitro Fertilization: A Multicenter, Randomized, Controlled, Assessor-Blinded, Phase 3 Noninferiority Trial","volume":"107","author":"Nyboe Andersen","year":"2017","journal-title":"Fertil Steril"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.repbio.2016.12.002","article-title":"Specific Ranges of Anti-Mullerian Hormone and Antral Follicle Count Correlate to Provide a Prognostic Indicator for IVF Outcome","volume":"17","author":"Keane","year":"2017","journal-title":"Reprod Biol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmt037","article-title":"Individualization of Controlled Ovarian Stimulation in IVF Using Ovarian Reserve Markers: From Theory to Practice","volume":"20","author":"la Marca","year":"2014","journal-title":"Hum Reprod Update"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmaa013","article-title":"Does an Association Exist Between Menstrual Cycle Length Within the Normal Range and Ovarian Reserve Biomarkers During the Reproductive Years? 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