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Endocrinol."],"abstract":"<jats:p>Growth differentiation factor-8 (GDF-8) is a member of the transforming growth factor-beta superfamily. Studies <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> have shown GDF-8 to be involved in the physiology and pathology of ovarian reproductive functions. <jats:italic>In vitro<\/jats:italic> experiments using a granulosa-cell model have demonstrated steroidogenesis, gonadotrophin responsiveness, glucose metabolism, cell proliferation as well as expression of lysyl oxidase and pentraxin 3 to be regulated by GDF-8 <jats:italic>via<\/jats:italic> the mothers against decapentaplegic homolog signaling pathway. Clinical data have shown that GDF-8 is expressed widely in the human ovary and has high expression in serum of obese women with polycystic ovary syndrome. GDF-8 expression in serum changes dynamically in patients undergoing controlled ovarian hyperstimulation. GDF-8 expression in serum and follicular fluid is correlated with the ovarian response and pregnancy outcome during <jats:italic>in vitro<\/jats:italic> fertilization. Blocking the GDF-8 signaling pathway is a potential therapeutic for ovarian hyperstimulation syndrome and ovulation disorders in polycystic ovary syndrome. GDF-8 has a regulatory role and potential importance in ovarian reproductive activity and may be involved in folliculogenesis, ovulation, and early embryo implantation.<\/jats:p>","DOI":"10.3389\/fendo.2022.878069","type":"journal-article","created":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T09:30:04Z","timestamp":1653557404000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Regulatory Role and Potential Importance of GDF-8 in Ovarian Reproductive 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