{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T12:19:15Z","timestamp":1786623555590,"version":"build-2736575974"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T00:00:00Z","timestamp":1654473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>This work aimed to evaluate the adverse effect of polycystic ovary syndrome (PCOS) on pregnancy outcomes of singletons after vitrification in women with frozen-thawed embryo transfer (FET).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with\/without PCOS who underwent FET from January 2013 and December 2018 were included. Propensity score matching (PSM) was used to reduce the influence of bias. Logistic regression was applied to identify the risk factors of adverse pregnancy outcomes of singletons in women with PCOS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>After PSM, the PCOS group had shorter gestational age (P&amp;lt;0.001) and lower newborn birth weight than the non-PCOS group (P=0.045). Compared with the non-PCOS group, the PCOS group had an increased risk of gestational diabetes mellitus (GDM) and pregnancy-induced hypertension (PIH) (P&amp;lt;0.001), placenta and membrane abnormality (P&amp;lt;0.001), stillbirth (P&amp;lt;0.001), neonatal complication (P=0.014), and miscarriage rate (P&amp;lt;0.001). Neonatal complication was associated with parity (adjusted OR=1.202, 95% CI=1.002\u20131.443, P=0.048) and basal P level (adjusted OR=1.211, 95% CI=1.021\u20131.436, P=0.028). According to multivariable logistic regression analysis, the miscarriage rate was related to parity (adjusted OR=1.201, 95% CI=1.057\u20131.166, P=0.005) and basal E2 (adjusted OR=1.002, 95% CI=1.000\u20131.004, P=0.019) and P levels on the day of embryo transfer (adjusted OR=0.971, 95% CI=0.957\u20130.985, P&amp;lt;0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Compared with non-PCOS women, women with PCOS have a higher risk of GDM and PIH, and neonatal complications and therefore require additional care during pregnancy and parturition.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2022.878853","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T04:59:11Z","timestamp":1654491551000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Adverse Effects of Polycystic Ovarian Syndrome on Pregnancy Outcomes in Women With Frozen-Thawed Embryo Transfer: Propensity Score-Matched Study"],"prefix":"10.3389","volume":"13","author":[{"given":"Zhexin","family":"Ni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siting","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoqin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem426","article-title":"Consensus on Infertility Treatment Related to Polycystic Ovary Syndrome","volume":"23","year":"2008","journal-title":"Hum Reprod"},{"key":"B2","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1093\/humupd\/dmw025","article-title":"The Management of Anovulatory Infertility in Women With Polycystic Ovary Syndrome: An Analysis of the Evidence to Support the Development of Global WHO Guidance","volume":"22","author":"Balen","year":"2016","journal-title":"Hum Reprod Update"},{"key":"B3","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/bf01204435","article-title":"A Comparative Study of Three Ovulation Induction Protocols in Polycystic Ovarian Disease Patients in an In Vitro Fertilization\/Embryo Transfer Program","volume":"10","author":"Turhan","year":"1993","journal-title":"J Assist Reprod Genet"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.4103\/jhrs.JHRS_96_20","article-title":"Do Basal Luteinizing Hormone and Luteinizing Hormone\/Follicle-Stimulating Hormone Ratio Have Significance in Prognosticating the Outcome of In Vitro Fertilization Cycles in Polycystic Ovary Syndrome","volume":"14","author":"Singh","year":"2021","journal-title":"J Hum Reprod Sci"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2014.102","article-title":"The Management of Patients With Polycystic Ovary Syndrome","volume":"10","author":"Jayasena","year":"2014","journal-title":"Nat Rev Endocrinol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa285","article-title":"Obesity, Polycystic Ovary Syndrome, and Infertility: A New Avenue for GLP-1 Receptor Agonists","volume":"105","author":"Cena","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2009.09.026","article-title":"Ovarian Function and Obesity\u2013Interrelationship, Impact on Women's Reproductive Lifespan and Treatment Options","volume":"316","author":"Racho\u0144","year":"2010","journal-title":"Mol Cell Endocrinol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmaa011","article-title":"Risk of Gestational Diabetes Mellitus in Women Achieving Singleton Pregnancy Spontaneously or After ART: A Systematic Review and Meta-Analysis","volume":"26","author":"Bosdou","year":"2020","journal-title":"Hum Reprod Update"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei311","article-title":"Combined Lifestyle Modification and Metformin in Obese Patients With Polycystic Ovary Syndrome. 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