{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:27:21Z","timestamp":1793212041251,"version":"4.5.0"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T00:00:00Z","timestamp":1650585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Sexual dysfunction (SD) in patients who suffer from inflammatory bowel disease (IBD) has not attracted widespread attention, and thus research studies are scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aims to evaluate the rates of SD in IBD compared with healthy individuals and elucidate the associated factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this cross-sectional study, the Female Sexual Function Index (FSFI) and the simplified version of the International Index of Erectile Function (IIEF-5) were filled by IBD patients, as well as healthy control individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 208 IBD patients, including 133 with Crohn\u2019s disease (CD) and 75 with ulcerative colitis (UC), and 190 healthy individuals filled out the questionnaires. In women, SD rates were 61.9% in the patients with IBD vs. 24.4% in the healthy controls (<jats:italic>p<\/jats:italic> &amp;lt; 0.01). In men, the rates of erectile dysfunction (ED) were 43.5% in the patients with IBD vs. 12.5% in the healthy controls (<jats:italic>p<\/jats:italic> &amp;lt; 0.01). Anxiety (OR, 3.092; 95%CI: 1.033-9.252, <jats:italic>p<\/jats:italic> = 0.044) and active perianal disease (OR, 4.481; 95%CI: 1.055-19.029, <jats:italic>p<\/jats:italic> = 0.042) were independent risk factors for SD in female IBD patients. age (OR, 1.050; 95%CI: 1.007-1.095, <jats:italic>p<\/jats:italic> = 0.022), depression (OR, 5.763; 95%CI: 1.864-17.821, <jats:italic>p<\/jats:italic> = 0.002) and active perianal disease (OR, 7.117; 95%CI: 1.747-28.983, <jats:italic>p<\/jats:italic> = 0.006) were independent risk factors for ED in male patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the IBD patients, 62% of women reported having SD, and 44% of men reported having ED. These higher rates, as compared to the healthy controls, are mostly driven by active perianal disease and psychological factors.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2022.881485","type":"journal-article","created":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T05:22:29Z","timestamp":1650604949000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":35,"title":["Prevalence and Associated Factors of Sexual Dysfunction in Patients With Inflammatory Bowel Disease"],"prefix":"10.3389","volume":"13","author":[{"given":"Jinzhi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qishan","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huatian","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2012.02.014","article-title":"Clinical Status, Psychosocial Impairments, Medical Treatment, and Health Care Costs for Patients With Inflammatory Bowel Disease (IBD) in Germany: An Online IBD Registry","volume":"7","author":"Bokemeyer","year":"2013","journal-title":"J Crohns Colitis"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide Incidence and Prevalence of Inflammatory Bowel Disease in the 21st Century: A Systematic Review of Population-Based Studies","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.150","article-title":"The Global Burden of IBD: From 2015 to 2025","volume":"12","author":"Kaplan","year":"2015","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1080\/0092623X.2015.1113597","article-title":"Burden of Sexual Dysfunction","volume":"43","author":"Balon","year":"2017","journal-title":"J Sex Marital Ther"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000259","article-title":"Sexual Dysfunction in Inflammatory Bowel Disease: \u201cDon\u2019t Ask, Don\u2019t Tell\u201d Doesn\u2019t Work","volume":"21","author":"Friedman","year":"2015","journal-title":"Inflamm Bowel Dis"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.01.018","article-title":"Illness Perceptions in IBD Influence Psychological Status, Sexual Health and Satisfaction, Body Image and Relational Functioning: A Preliminary Exploration Using Structural Equation Modeling","volume":"7","author":"Knowles","year":"2013","journal-title":"J Crohns Colitis"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.53","article-title":"Assessment Of Sexual Function Among Inflammatory Bowel Disease Patients","volume":"110","author":"Mahmood","year":"2015","journal-title":"Am J Gastroenterol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjv140","article-title":"Inflammatory Bowel Disease and Sexual Function in Male and Female Patients: An Update on Evidence in the Past Ten Years","volume":"9","author":"Mantzouranis","year":"2015","journal-title":"J Crohns Colitis"},{"key":"B9","article-title":"Development of a Crohn\u2019s Disease Activity Index","volume":"70","author":"Best","year":"1976","journal-title":"Natl Cooperative Crohn\u2019s Dis Study Gastroenterol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050516","article-title":"Infliximab for Induction and Maintenance Therapy for Ulcerative Colitis","volume":"353","author":"Rutgeerts","year":"2005","journal-title":"N Engl J Med"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.07.013","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for Reporting Observational Studies","volume":"12","author":"von Elm","year":"2014","journal-title":"Int J Surg"},{"key":"B12","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1111\/1751-2980.12994","article-title":"Chinese Consensus on Diagnosis and Treatment of Inflammatory Bowel Disease (Beijing, 2018)","volume":"38","author":"Wu","year":"2018","journal-title":"Chin J Pract Internal Med"},{"key":"B13","first-page":"198","article-title":"Reliability and Validity of Hospital Anxiety and Depression Scale","volume":"11","author":"Sun","year":"2017","journal-title":"Chin J Clin (Electronic Edition)"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2010.02171.x","article-title":"Development and Validation of Chinese Version of Female Sexual Function Index in a Chinese Population-a Pilot Study","volume":"8","author":"Sun","year":"2011","journal-title":"J Sex Med"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3900472","article-title":"Development and Evaluation of an Abridged, 5-Item Version of the International Index of Erectile Function (IIEF-5) as a Diagnostic Tool for Erectile Dysfunction","volume":"11","author":"Rosen","year":"1999","journal-title":"Int J Impot Res"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjx100","article-title":"Frequency of and Factors Associated With Sexual Dysfunction in Patients With Inflammatory Bowel Disease","volume":"11","author":"Rivi\u00e8re","year":"2017","journal-title":"J Crohns Colitis"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izx053","article-title":"Sexual Dysfunction in Men With Inflammatory Bowel Disease: A New IBD-Specific Scale","volume":"24","author":"O\u2019Toole","year":"2018","journal-title":"Inflamm Bowel Dis"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12913","article-title":"Sexual Dysfunctions in Men and Women With Inflammatory Bowel Disease: The Influence of IBD-Related Clinical Factors and Depression on Sexual Function","volume":"12","author":"Bel","year":"2015","journal-title":"J Sex Med"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-012-0700-2","article-title":"Sexual Function and Patients\u2019 Perceptions in Inflammatory Bowel Disease: A Case-Control Survey","volume":"48","author":"Mar\u00edn","year":"2013","journal-title":"J Gastroenterol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.cgh.2006.10.018","article-title":"Sexual Function in Persons With Inflammatory Bowel Disease: A Survey With Matched Controls","volume":"5","author":"Timmer","year":"2007","journal-title":"Clin Gastroenterol Hepatol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20182","article-title":"Determinants of Male Sexual Function in Inflammatory Bowel Disease: A Survey-Based Cross-Sectional Analysis in 280 Men","volume":"13","author":"Timmer","year":"2007","journal-title":"Inflamm Bowel Dis"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1159\/000200951","article-title":"Sexual Dysfunction Amongst Women With Crohn\u2019s Disease: A Hidden Problem","volume":"52","author":"Moody","year":"1992","journal-title":"Digestion"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1097\/00054725-201212001-00104","article-title":"P-71 An Update on the CCFA Partners Internet Cohort Study","volume":"18","author":"Kappelman","year":"2012","journal-title":"Inflamm Bowel Dis"},{"key":"B24","doi-asserted-by":"crossref","first-page":"S","DOI":"10.1016\/S0016-5085(12)62571-2","article-title":"Mo1716 Significant Sexual Dysfunction in Patients With Perianal Crohn\u2019s Disease Improves With Multimodality Treatment","volume":"142","author":"Horst","year":"2012","journal-title":"Gastroenterology"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2018.18250","article-title":"The Influence of Disease Type and Activity to Sexual Life and Health Quality in Inflammatory Bowel Disease","volume":"30","author":"Ate\u015f Bulut","year":"2019","journal-title":"Turk J Gastroenterol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12720","article-title":"Review Article: The Psychosexual Impact of Inflammatory Bowel Disease in Male Patients","volume":"39","author":"O\u2019Toole","year":"2014","journal-title":"Aliment Pharmacol Ther"},{"key":"B27","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/s0016-5085(03)00699-1","article-title":"Acquired Microvascular Dysfunction in Inflammatory Bowel Disease: Loss of Nitric Oxide-Mediated Vasodilation","volume":"125","author":"Hatoum","year":"2003","journal-title":"Gastroenterology"},{"key":"B28","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1093\/ibd\/izy345","article-title":"Inflammatory Bowel Diseases Were Associated With Risk of Sexual Dysfunction in Both Sexes: A Meta-Analysis","volume":"25","author":"Zhao","year":"2019","journal-title":"Inflammation Bowel Dis"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/s0889-8553(05)70056-x","article-title":"Epidemiology and the Natural Course of Inflammatory Bowel Disease","volume":"28","author":"Andres","year":"1999","journal-title":"Gastroenterol Clin North Am"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000753","article-title":"Rates and Reasons for Nonuse of Prescription Medication for Inflammatory Bowel Disease in a Referral Clinic","volume":"22","author":"Bhasin","year":"2016","journal-title":"Inflamm Bowel Dis"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.881485\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T14:21:06Z","timestamp":1651069266000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.881485\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,22]]},"references-count":30,"alternative-id":["10.3389\/fendo.2022.881485"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2022.881485","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,22]]},"article-number":"881485"}}