{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:04:05Z","timestamp":1793660645319,"version":"4.5.1"},"reference-count":195,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T00:00:00Z","timestamp":1651104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017292","name":"Ovarian Cancer Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017292","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Epithelial ovarian cancer (EOC) is considered the deadliest gynecological disease and is normally diagnosed at late stages, at which point metastasis has already occurred. Throughout disease progression, EOC will encounter various ecosystems and the communication between cancer cells and these microenvironments will promote the survival and dissemination of EOC. The primary tumor is thought to develop within the ovaries or the fallopian tubes, both of which provide a microenvironment with high risk of causing DNA damage and enhanced proliferation. EOC disseminates by direct extension from the primary tumors, as single cells or multicellular aggregates. Under the influence of cellular and non-cellular factors, EOC spheroids use the natural flow of peritoneal fluid to reach distant organs within the peritoneal cavity. These cells can then implant and seed distant organs or tissues, which develop rapidly into secondary tumor nodules. The peritoneal tissue and the omentum are two common sites of EOC metastasis, providing a microenvironment that supports EOC invasion and survival. Current treatment for EOC involves debulking surgery followed by platinum-taxane combination chemotherapy; however, most patients will relapse with a chemoresistant disease with tumors developed within the peritoneum. Therefore, understanding the role of the unique microenvironments that promote EOC transcoelomic dissemination is important in improving patient outcomes from this disease. In this review article, we address the process of ovarian cancer cellular fate at the site of its origin in the secretory cells of the fallopian tube or in the ovarian surface epithelial cells, their detachment process, how the cells survive in the peritoneal fluid avoiding cell death triggers, and how cancer- associated cells help them in the process. Finally, we report the mechanisms used by the ovarian cancer cells to adhere and migrate through the mesothelial monolayer lining the peritoneum. We also discuss the involvement of the transcoelomic ecosystem on the development of chemoresistance of EOC.<\/jats:p>","DOI":"10.3389\/fendo.2022.886533","type":"journal-article","created":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T05:24:53Z","timestamp":1651123493000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":63,"title":["The Transcoelomic Ecosystem and Epithelial Ovarian Cancer Dissemination"],"prefix":"10.3389","volume":"13","author":[{"given":"Sabrina J.","family":"Ritch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos M.","family":"Telleria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20040952","article-title":"High-Grade Serous Ovarian Cancer: Basic Sciences, Clinical and Therapeutic Standpoints","volume":"20","author":"Lisio","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(06)70939-1","article-title":"Mechanisms of Transcoelomic Metastasis in Ovarian Cancer","volume":"7","author":"Tan","year":"2006","journal-title":"Lancet Oncol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.09.005","article-title":"Mesothelial Cells and Peritoneal Homeostasis","volume":"106","author":"Mutsaers","year":"2016","journal-title":"Fertil Steril"},{"key":"B4","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.tice.2016.11.004","article-title":"The Histophysiology and Pathophysiology of the Peritoneum","volume":"49","author":"van Baal","year":"2017","journal-title":"Tissue Cell"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.22.2.0422","article-title":"Ovarian Surface Epithelium: Biology, Endocrinology, and Pathology","volume":"22","author":"Auersperg","year":"2001","journal-title":"Endocr Rev"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dml012","article-title":"The Reproductive Significance of Human Fallopian Tube Cilia","volume":"12","author":"Lyons","year":"2006","journal-title":"Hum Reprod Update"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(99)90269-1","article-title":"Altered Surface and Cyst Epithelium of Ovaries Removed Prophylactically From Women With a Family History of Ovarian Cancer","volume":"30","author":"Werness","year":"1999","journal-title":"Hum Pathol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11847","article-title":"Morphologic Precursors of Ovarian Epithelial Tumors","volume":"82","author":"Resta","year":"1993","journal-title":"Obstet Gynecol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/152.3.233","article-title":"Risk of Ovarian Cancer in Relation to Estrogen and Progestin Dose and Use Characteristics of Oral Contraceptives. 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