{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:31:16Z","timestamp":1790620276323,"version":"4.1.0"},"reference-count":89,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T00:00:00Z","timestamp":1655856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Polycystic ovary syndrome (PCOS) is a polyendocrine disorder and the most common endocrinopathy in women of reproductive age. Affected women have an elevated prevalence of being overweight and obese. Our study sought to determine how weight loss associated with lifestyle changes affects the endometrium specific proteome, endocrine-metabolic characteristics, and motor capabilities of obese women with PCOS and infertility. A group of 12 infertile women under the age of 38 with PCOS and BMI \u226530 kg\/m<jats:sup>2<\/jats:sup>were included in the study. An evaluation was performed by a gynecologist and an endocrinologist. The weight-loss program lasted 8 weeks under the guidance of a professional trainer. Endometrial sampling during a period of implantation window for proteome determination was performed before and after weight loss. In endometrial samples at the end of the study increased protein abundance was recorded for Legumain, Insulin-like growth factor-binding protein 7, Hepatocyte growth factor receptor, Keratin, type II cytoskeletal 7, and Cystatin-B, while the B-lymphocyte antigen CD20 protein abundance decreased. Our results also indicate significantly lowered fasting blood glucose level and free testosterone concentration and significant improvements in body composition and physical capacity. This study may open up the venues for investigating important biomarkers that may affect endometrial receptivity.<\/jats:p><jats:sec><jats:title>Clinical Trial Registration<\/jats:title><jats:p><jats:uri>https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04989244?term=NCT04989244&amp;amp;draw=2&amp;amp;rank=1<\/jats:uri>, identifier: NCT04989244.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2022.888460","type":"journal-article","created":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T12:33:59Z","timestamp":1655901239000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["The Lifestyle Modifications and Endometrial Proteome Changes of Women With Polycystic Ovary Syndrome and Obesity"],"prefix":"10.3389","volume":"13","author":[{"given":"D.","family":"Abdulkhalikova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sustarsic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eda","family":"Vrta\u010dnik Bokal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Jancar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Jensterle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Burnik Papler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1093\/humrep\/der396","article-title":"Consensus on Women's Health Aspects of Polycystic Ovary Syndrome (PCOS)","volume":"27","year":"2012","journal-title":"Hum Reprod"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dms030","article-title":"Overweight, Obesity and Central Obesity in Women With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis","volume":"18","author":"Lim","year":"2012","journal-title":"Hum Reprod Update"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041536","article-title":"Polycystic Ovary Syndrome","volume":"352","author":"Ehrmann","year":"2005","journal-title":"N Engl J Med"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801994","article-title":"Obesity and the Polycystic Ovary Syndrome","volume":"26","author":"Gambineri","year":"2002","journal-title":"Int J Obes Relat Metab Disord"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1530\/REP-09-0568","article-title":"The Adverse Effects of Obesity on Conception and Implantation","volume":"140","author":"Brewer","year":"2010","journal-title":"Reproduction"},{"key":"B6","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1080\/19396368.2017.1410591","article-title":"Sex Hormone Binding Globulin - an Important Biomarker for Predicting PCOS Risk: A Systematic Review and Meta-Analysis","volume":"64","author":"Deswal","year":"2018","journal-title":"Syst Biol Reprod Med"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.546","article-title":"Anovulation","volume":"327","author":"Hamilton-Fairley","year":"2003","journal-title":"BMJ"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmm017","article-title":"Effect of Overweight and Obesity on Assisted Reproductive Technology-a Systematic Review","volume":"13","author":"Maheshwari","year":"2007","journal-title":"Hum Reprod Update"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.04.063","article-title":"Morbid Obesity is Associated With Lower Clinical Pregnancy Rates After In Vitro Fertilization in Women With Polycystic Ovary Syndrome","volume":"92","author":"Jungheim","year":"2009","journal-title":"Fertil Steril"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.12.032","article-title":"Female Obesity Impairs In Vitro Fertilization Outcome Without Affecting Embryo Quality","volume":"93","author":"Bellver","year":"2010","journal-title":"Fertil Steril"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000219768.08249.b6","article-title":"Obstetric Outcomes After In Vitro Fertilization in Obese and Morbidly Obese Women","volume":"108","author":"Dokras","year":"2006","journal-title":"Obstet Gynecol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.07.1290","article-title":"Does High Body Mass Index Increase the Risk of Miscarriage After Spontaneous and Assisted Conception? 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