{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:42:45Z","timestamp":1793194965383,"version":"4.5.0"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T00:00:00Z","timestamp":1654214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      This study aims to evaluate the association between polycystic ovary syndrome (PCOS) phenotypes and adverse perinatal outcomes, comparing the characteristics, ovarian response, and assisted reproductive outcomes in patients with various PCOS phenotypes after\n                      <jats:italic>in-vitro<\/jats:italic>\n                      fertilization (IVF)\/intracytoplasmic sperm injection (ICSI).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study comprised 6,732 patients who underwent the first cycle of IVF\/ICSI treatment in our outpatient department from January 2017 to July 2018. Propensity score matching (PSM) was used in PCOS and non-PCOS groups to balance the influence of intergroup confounding factors. After the PSM procedure, 1,186 patients were included in the two groups, and the PCOS patients were further divided into four PCOS phenotype groups based on the Rotterdam criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with various PCOS phenotypes had similar rates of biochemical pregnancy, clinical pregnancy, and live birth (all\n                      <jats:italic>P<\/jats:italic>\n                      -values\u00a0&amp;gt;\u00a00.05). The overall incidence of adverse pregnancy outcomes (including ectopic pregnancy, miscarriage, preterm birth) was significantly higher in PCOS phenotype A and D groups than in the control group (44% and 46.4% vs. 28.7%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.027). The rates of hypertensive disorder of pregnancy (HDP) were significantly higher in PCOS phenotype A and C groups than in the control group (9.3% and 12.5% vs. 3.1%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.037). After adjustment for potential confounders, the differences in adverse pregnancy outcomes persisted (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.025).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The overall incidence of adverse pregnancy outcomes is higher in women with PCOS phenotypes A and D than in women with non-PCOS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2022.889029","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T01:18:14Z","timestamp":1654219094000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["Association of Polycystic Ovary Syndrome Phenotypes With Adverse Pregnancy Outcomes After In-Vitro Fertilization\/Intracytoplasmic Sperm Injection"],"prefix":"10.3389","volume":"13","author":[{"given":"Qiumin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiufang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2016.1188280","article-title":"Serum Anti-Mullerian Hormone Levels After Ovarian Drilling for the Second-Line Treatment of Polycystic Ovary Syndrome: A Pilot-Randomized Study Comparing Laparoscopy and Transvaginal Hydrolaparoscopy","volume":"33","author":"Giampaolino","year":"2017","journal-title":"Gynecol Endocrinol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2020.1781815","article-title":"Current and Experimental Drug Therapy for the Treatment of Polycystic Ovarian Syndrome","volume":"29","author":"Della Corte","year":"2020","journal-title":"Expert Opin Investig Drugs"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2017.1323204","article-title":"Operative Transvaginal Hydrolaparoscopy Improve Ovulation Rate After Clomiphene Failure in Polycystic Ovary Syndrome","volume":"34","author":"Giampaolino","year":"2018","journal-title":"Gynecol Endocrinol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.fertnstert.2016.05.003","article-title":"Criteria, Prevalence, and Phenotypes of Polycystic Ovary Syndrome","volume":"106","author":"Lizneva","year":"2016","journal-title":"Fertil Steril"},{"key":"B5","doi-asserted-by":"publisher","first-page":"2048","DOI":"10.3390\/ijms22042048","article-title":"Microbiome and PCOS: State-Of-Art and Future Aspects","volume":"22","author":"Giampaolino","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B6","doi-asserted-by":"publisher","first-page":"16057","DOI":"10.1038\/nrdp.2016.57","article-title":"Polycystic Ovary Syndrome","volume":"2","author":"Azziz","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2017.1391205","article-title":"Ovarian Volume and PCOS: A Controversial Issue","volume":"34","author":"Giampaolino","year":"2018","journal-title":"Gynecol Endocrinol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2017.1412429","article-title":"Ovarian Response to Controlled Ovarian Stimulation in Women With Different Polycystic Ovary Syndrome Phenotypes","volume":"34","author":"Cela","year":"2018","journal-title":"Gynecol Endocrinol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13828","article-title":"Comorbidities and Complications of Polycystic Ovary Syndrome: An Overview of Systematic Reviews","volume":"89","author":"Gilbert","year":"2018","journal-title":"Clin Endocrinol (Oxf)"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13579","article-title":"Polycystic Ovary Syndrome and Adverse Pregnancy Outcomes: Current State of Knowledge, Challenges and Potential Implications for Practice","volume":"88","author":"Bahri Khomami","year":"2018","journal-title":"Clin Endocrinol (Oxf)"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.12.023","article-title":"Comparing the Risk of Adverse Pregnancy Outcomes of Chinese Patients With Polycystic Ovary Syndrome With and Without Antiandrogenic Pretreatment","volume":"109","author":"Li","year":"2018","journal-title":"Fertil Steril"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2019-00383","article-title":"A Narrative Review of Placental Contribution to Adverse Pregnancy Outcomes in Women With Polycystic Ovary Syndrome","volume":"104","author":"Kelley","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.07.1075","article-title":"Perinatal Outcome of Singleton Siblings Born After Assisted Reproductive Technology and Spontaneous Conception: Danish National Sibling-Cohort Study","volume":"95","author":"Henningsen","year":"2011","journal-title":"Fertil Steril"},{"key":"B14","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1093\/humupd\/dms044","article-title":"Why do Singletons Conceived After Assisted Reproduction Technology Have Adverse Perinatal Outcome? Systematic Review and Meta-Analysis","volume":"19","author":"Pinborg","year":"2013","journal-title":"Hum Reprod Update"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1016\/j.fertnstert.2015.03.018","article-title":"Pregnancy-Related Complications and Adverse Pregnancy Outcomes in Multiple Pregnancies Resulting From Assisted Reproductive Technology: A Meta-Analysis of Cohort Studies","volume":"103","author":"Qin","year":"2015","journal-title":"Fertil Steril"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2019.03.203","article-title":"A Meta-Analysis of Pregnancy-Related Outcomes and Complications in Women With Polycystic Ovary Syndrome Undergoing IVF","volume":"39","author":"Sha","year":"2019","journal-title":"Reprod BioMed Online"},{"key":"B17","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","article-title":"Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome","volume":"81","year":"2004","journal-title":"Fertil Steril"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1513873","article-title":"Fresh Versus Frozen Embryos for Infertility in the Polycystic Ovary Syndrome","volume":"375","author":"Chen","year":"2016","journal-title":"New Engl J Med"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61345-2","article-title":"Polycystic Ovary Syndrome","volume":"370","author":"Norman","year":"2007","journal-title":"Lancet"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1705334","article-title":"Transfer of Fresh Versus Frozen Embryos in Ovulatory Women","volume":"378","author":"Shi","year":"2018","journal-title":"New Engl J Med"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.491892","article-title":"Lipid Metabolic Disorders and Ovarian Hyperstimulation Syndrome: A Retrospective Analysis","volume":"11","author":"Liu","year":"2020","journal-title":"Front Physiol"},{"key":"B22","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1067\/mob.2000.107928","article-title":"Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy","volume":"183","year":"2000","journal-title":"Am J Obstet Gynecol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/S0140-6736(15)00070-7","article-title":"Pre-Eclampsia","volume":"387","author":"Mol","year":"2016","journal-title":"Lancet (London England)"},{"key":"B24","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s12199-020-00889-y","article-title":"Weekend and Off-Hour Effects on the Incidence of Cerebral Palsy: Contribution of Consolidated Perinatal Care","volume":"25","author":"Toyokawa","year":"2020","journal-title":"Environ Health Prev Med"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0378","article-title":"Endocrinology of Pregnancy: Gestational Diabetes Mellitus: Definition, Aetiological and Clinical Aspects","volume":"174","author":"Baz","year":"2016","journal-title":"Eur J Endocrinol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004863","article-title":"Association Between Polycystic Ovary Syndrome and the Risk of Pregnancy Complications: A PRISMA-Compliant Systematic Review and Meta-Analysis","volume":"95","author":"Yu","year":"2016","journal-title":"Medicine"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.740377","article-title":"Association Between Menstrual Patterns and Adverse Pregnancy Outcomes in Patients With Polycystic Ovary Syndrome","volume":"12","author":"Yu","year":"2021","journal-title":"Front Endocrinol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2006.03.005","article-title":"Endometrium in PCOS: Implantation and Predisposition to Endocrine CA","volume":"20","author":"Giudice","year":"2006","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"B29","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.bpobgyn.2016.03.008","article-title":"Polycystic Ovary Syndrome: Endometrial Markers","volume":"37","author":"Piltonen","year":"2016","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.12.015","article-title":"Menstrual Dysfunction in Polycystic Ovary Syndrome: Association With Dynamic State Insulin Resistance Rather Than Hyperandrogenism","volume":"115","author":"Ezeh","year":"2021","journal-title":"Fertil Steril"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)58330-7","article-title":"Production of Embryos From In Vitro-Matured Primary Human Oocytes","volume":"65","author":"Barnes","year":"1996","journal-title":"Fertil Steril"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2016.04.038","article-title":"Mechanisms Underlying Reduced Fertility in Anovular Dairy Cows","volume":"86","author":"Santos","year":"2016","journal-title":"Theriogenology"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(01)01937-9","article-title":"Diastolic Dysfunction and Increased Serum Homocysteine Concentrations may Contribute to Increased Cardiovascular Risk in Patients With Polycystic Ovary Syndrome","volume":"76","author":"Yarali","year":"2001","journal-title":"Fertil Steril"},{"key":"B34","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.ejogrb.2006.10.015","article-title":"Plasma Homocysteine and Polycystic Ovary Syndrome: The Missed Link","volume":"131","author":"Badawy","year":"2007","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg190","article-title":"Insulin Resistance in Patients With Polycystic Ovary Syndrome is Associated With Elevated Plasma Homocysteine","volume":"18","author":"Schachter","year":"2003","journal-title":"Hum Reprod"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep069","article-title":"Homocysteine Concentrations in Follicular Fluid are Associated With Poor Oocyte and Embryo Qualities in Polycystic Ovary Syndrome Patients Undergoing Assisted Reproduction","volume":"24","author":"Berker","year":"2009","journal-title":"Hum Reprod"},{"key":"B37","doi-asserted-by":"publisher","first-page":"19436","DOI":"10.1038\/srep19436","article-title":"Abnormally Activated One-Carbon Metabolic Pathway is Associated With mtDNA Hypermethylation and Mitochondrial Malfunction in the Oocytes of Polycystic Gilt Ovaries","volume":"6","author":"Jia","year":"2016","journal-title":"Sci Rep"},{"key":"B38","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.bpobgyn.2020.07.005","article-title":"Advanced Maternal Age and Adverse Pregnancy Outcomes","volume":"70","author":"Frick","year":"2021","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002786","article-title":"Maternal and Fetal Risk Associated With Assisted Reproductive Technology","volume":"132","author":"Kawwass","year":"2018","journal-title":"Obstet Gynecol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"2838","DOI":"10.3390\/nu12092838","article-title":"The Influence of Maternal BMI on Adverse Pregnancy Outcomes in Older Women","volume":"12","author":"Lewandowska","year":"2020","journal-title":"Nutrients"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002710","article-title":"Metabolic Syndrome in Pregnancy and Risk for Adverse Pregnancy Outcomes: A Prospective Cohort of Nulliparous Women","volume":"15","author":"Grieger","year":"2018","journal-title":"PloS Med"},{"key":"B42","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s12958-021-00738-9","article-title":"Thin Endometrium is Associated With the Risk of Hypertensive Disorders of Pregnancy in Fresh IVF\/ICSI Embryo Transfer Cycles: A Retrospective Cohort Study of 9,266 Singleton Births","volume":"19","author":"Liu","year":"2021","journal-title":"Reprod Biol Endocrinol"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.03.039","article-title":"Defective Endometrial Receptivity","volume":"97","author":"Revel","year":"2012","journal-title":"Fertil Steril"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.12.014","article-title":"Endometrial Thickness is Associated With Incidence of Small-for-Gestational-Age Infants in Fresh In Vitro Fertilization-Intracytoplasmic Sperm Injection and Embryo Transfer Cycles","volume":"113","author":"Guo","year":"2020","journal-title":"Fertil Steril"},{"key":"B45","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1080\/09513590.2021.1897096","article-title":"Association Between Hyperandrogenism and Adverse Pregnancy Outcomes in Patients With Different Polycystic Ovary Syndrome Phenotypes Undergoing In Vitro Fertilization\/Intracytoplasmic Sperm Injection: A Systematic Review and Meta-Analysis","volume":"37","author":"Ma","year":"2021","journal-title":"Gynecol Endocrinol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2018.1431773","article-title":"Infertile Polycystic Ovary Syndrome Patients Undergoing In Vitro Fertilization With the Gonadotropin-Releasing Hormone-Antagonist Protocol: Role of Hyperandrogenism","volume":"34","author":"Yang","year":"2018","journal-title":"Gynecol Endocrinol"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.592495","article-title":"High BMI and Insulin Resistance Are Risk Factors for Spontaneous Abortion in Patients With Polycystic Ovary Syndrome Undergoing Assisted Reproductive Treatment: A Systematic Review and Meta-Analysis","volume":"11","author":"Sun","year":"2020","journal-title":"Front Endocrinol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2014.04.015","article-title":"Is Severe OHSS Associated With Adverse Pregnancy Outcomes? Evidence From a Case-Control Study","volume":"29","author":"Haas","year":"2014","journal-title":"Reprod BioMed Online"},{"key":"B49","doi-asserted-by":"publisher","first-page":"34538","DOI":"10.1038\/srep34538","article-title":"Analyses of Optimal Body Mass Index for Infertile Patients With Either Polycystic or non-Polycystic Ovary Syndrome During Assisted Reproductive Treatment in China","volume":"6","author":"Wang","year":"2016","journal-title":"Sci Rep"},{"key":"B50","doi-asserted-by":"publisher","first-page":"Cd012103","DOI":"10.1002\/14651858.CD012103.pub2","article-title":"Interventions for the Prevention of OHSS in ART Cycles: An Overview of Cochrane Reviews","volume":"1","author":"Mourad","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.10.043","article-title":"Pregnancy in Women With Polycystic Ovary Syndrome: The Effect of Different Phenotypes and Features on Obstetric and Neonatal Outcomes","volume":"94","author":"Palomba","year":"2010","journal-title":"Fertil Steril"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.889029\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T01:18:21Z","timestamp":1654219101000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.889029\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,3]]},"references-count":51,"alternative-id":["10.3389\/fendo.2022.889029"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2022.889029","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,3]]},"article-number":"889029"}}