{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:22:20Z","timestamp":1793384540571,"version":"4.5.0"},"reference-count":100,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:00:00Z","timestamp":1658707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001322","name":"South African Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["120832"],"award-info":[{"award-number":["120832"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Maternal diabetes is associated with pregnancy complications and poses a serious health risk to both mother and child. Growing evidence suggests that pregnancy complications are more frequent and severe in pregnant women with pregestational type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) compared to women with gestational diabetes mellitus (GDM). Elucidating the pathophysiological mechanisms that underlie the different types of maternal diabetes may lead to targeted strategies to prevent or reduce pregnancy complications. In recent years, microRNAs (miRNAs), one of the most common epigenetic mechanisms, have emerged as key players in the pathophysiology of pregnancy-related disorders including diabetes. This review aims to provide an update on the status of miRNA profiling in pregnancies complicated by maternal diabetes. Four databases, Pubmed, Web of Science, EBSCOhost, and Scopus were searched to identify studies that profiled miRNAs during maternal diabetes. A total of 1800 articles were identified, of which 53 are included in this review. All studies profiled miRNAs during GDM, with no studies on miRNA profiling during pregestational T1DM and T2DM identified. Studies on GDM were mainly focused on the potential of miRNAs to serve as predictive or diagnostic biomarkers. This review highlights the lack of miRNA profiling in pregnancies complicated by T1DM and T2DM and identifies the need for miRNA profiling in all types of maternal diabetes. Such studies could contribute to our understanding of the mechanisms that link maternal diabetes type with pregnancy complications.<\/jats:p>","DOI":"10.3389\/fendo.2022.892587","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T06:43:43Z","timestamp":1658731423000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["A Big Role for microRNAs in Gestational Diabetes Mellitus"],"prefix":"10.3389","volume":"13","author":[{"given":"Matladi","family":"Masete","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nompumelelo","family":"Malaza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumaiya","family":"Adam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Pheiffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2707","DOI":"10.3390\/jcm9092707","article-title":"Materno-Fetal and Neonatal Complications of Diabetes in Pregnancy: A Retrospective Study","volume":"9","author":"Capobianco","year":"2020","journal-title":"J Clin Med"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22062965","article-title":"Diabetes During Pregnancy: A Maternal Disease Complicating the Course of Pregnancy With Long-Term Deleterious Effects on the Offspring. A Clinical Review","volume":"22","author":"Ornoy","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B3","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-030-89243-2_19","article-title":"Long-Term Maternal Complications","volume-title":"Comprehensive Clinical Approach to Diabetes During Pregnancy","author":"Kakotrichi","year":"2022"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112183","article-title":"Gestational Diabetes Mellitus - A Metabolic and Reproductive Disorder","volume":"143","author":"Choudhury","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"B5","unstructured":"IDF Diabetes Atlas2021"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-019-4961-7","article-title":"Characteristics and pregnancy outcomes across gestational diabetes mellitus subtypes based on insulin resistance","volume":"62","author":"Benhalima","year":"2019","journal-title":"Diabetologia"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-0261","article-title":"Association of Maternal Prepregnancy Diabetes and Gestational Diabetes Mellitus With Congenital Anomalies of the Newborn","volume":"43","author":"Wu","year":"2020","journal-title":"Diabetes Care"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2018.01.002","article-title":"Pregestational Diabetes in Pregnancy","volume":"45","author":"Sugrue","year":"2018","journal-title":"Obstet Gynecology Clin North Am"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5718","article-title":"Pregestational Diabetes in Pregnancy: Complications, Management, Surveillance, and Mechanisms of Disease\u2014A Review","volume":"40","author":"Shub","year":"2020","journal-title":"PrenatDiagn"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2015.08.004","article-title":"Type 1, Type 2 and Gestational Diabetes Mellitus Differentially Impact Placental Pathologic Characteristics of Uteroplacental Malperfusion","volume":"36","author":"Huynh","year":"2015","journal-title":"Placenta"},{"key":"B11","doi-asserted-by":"publisher","first-page":"2502","DOI":"10.2337\/dc18-0733","article-title":"Maternal Gestational Diabetes Mellitus, Type 1 Diabetes, and Type 2 Diabetes During Pregnancy and Risk of ADHD in Offspring","volume":"41","author":"Xiang","year":"2018","journal-title":"Diabetes Care"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90529-y","article-title":"The C. Elegans Heterochronic Gene Lin-4 Encodes Small RNAs With Antisense Complementarity to Lin-14","volume":"75","author":"Lee","year":"1993","journal-title":"Cell"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00402","article-title":"Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation","volume":"9","author":"O\u2019Brien","year":"2018","journal-title":"Front Endocrinol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.2337\/db17-1207","article-title":"Circulating miRNA Profiles Associated With Hyperglycemia in Patients With Type 1 Diabetes","volume":"67","author":"Satake","year":"2018","journal-title":"Diabetes"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz097","article-title":"An estimate of the total number of true human miRNAs","volume":"47","author":"Alles","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"B16","doi-asserted-by":"publisher","first-page":"E296","DOI":"10.1155\/2017\/6972732","article-title":"The Pattern of microRNA Binding Site Distribution","volume":"8","author":"Zhang","year":"2017","journal-title":"Genes"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/ng1536","article-title":"Combinatorial microRNA Target Predictions","volume":"37","author":"Krek","year":"2005","journal-title":"Nat Genet"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13027","article-title":"Exosomes as new players in metabolic organ cross-talk","volume":"19","author":"Guay","year":"2017","journal-title":"Diabetes Obes Metab"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2018.05.002","article-title":"Circulating miRNAs as Predictive Biomarkers of Type 2 Diabetes Mellitus Development in Coronary Heart Disease Patients from the CORDIOPREV Study","volume":"12","author":"Jim\u00e9nez-Lucena","year":"2018","journal-title":"Mol Ther - Nucleic Acids"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1111\/ijpo.12247","article-title":"Differential Expression Profiles of Circulating Micrornas in Newborns Associated to Maternal Pregestational Overweight and Obesity: Newborns Mirnas Alterations","volume":"13","author":"M\u00e9ndez-Mancilla","year":"2018","journal-title":"Pediatr Obes"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.07.001","article-title":"Placental Exosomes in Normal and Complicated Pregnancy","volume":"213","author":"Mitchell","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6972732","article-title":"Small Molecule, Big Prospects: MicroRNA in Pregnancy and Its Complications","volume":"2017","author":"Cai","year":"2017","journal-title":"J Pregnancy"},{"key":"B23","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s11892-017-0856-5","article-title":"MicroRNAs in Pregnancy and Gestational Diabetes Mellitus: Emerging Role in Maternal Metabolic Regulation","volume":"17","author":"Poirier","year":"2017","journal-title":"Curr Diabetes Rep"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2014.06.002","article-title":"Circulating Levels of Maternal Plasma Cell-Free Pregnancy-Associated Placenta-Specific microRNAs Are Associated With Placental Weight","volume":"35","author":"Miura","year":"2014","journal-title":"Placenta"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1177\/1933719116653837","article-title":"Circulating Levels of Pregnancy-Associated, Placenta-Specific microRNAs in Pregnant Women With Placental Abruption","volume":"24","author":"Miura","year":"2016","journal-title":"Reprod Sci Thousand Oaks Calif"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1177\/1933719115589407","article-title":"Increased Levels of Cell-Free miR-517a and Decreased Levels of Cell-Free miR-518b in Maternal Plasma Samples From Placenta Previa Pregnancies at 32 Weeks of Gestation","volume":"22","author":"Hasegawa","year":"2015","journal-title":"Reprod Sci Thousand Oaks Calif"},{"key":"B27","doi-asserted-by":"publisher","first-page":"186041","DOI":"10.1155\/2013\/186041","article-title":"Circulating C19MC microRNAs in Preeclampsia, Gestational Hypertension, and Fetal Growth Restriction","volume":"2013","author":"Hromadnikova","year":"2013","journal-title":"Mediators Inflammation"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0171756","article-title":"First Trimester Screening of Circulating C19MC microRNAs and the Evaluation of Their Potential to Predict the Onset of Preeclampsia and IUGR","volume":"12","author":"Hromadnikova","year":"2017","journal-title":"PloS One"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1177\/1933719114561557","article-title":"Serum MicroRNAs as Diagnostic Biomarkers for Macrosomia","volume":"22","author":"Jiang","year":"2015","journal-title":"Reprod Sci"},{"key":"B30","article-title":"Screening for Gestational Diabetes Mellitus: The Potential of microRNAs","volume-title":"IntechOpen","author":"Pheiffer","year":"2018"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1080\/09674845.2020.1764211","article-title":"Circulating Micro RNA-223 and Angiopoietin-Like Protein 8 as Biomarkers of Gestational Diabetes Mellitus","volume":"78","author":"Abdeltawab","year":"2020","journal-title":"Br J Biomed Science"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1515\/tjb-2019-0157","article-title":"Expression Level of miRNAS in Patients With Gestational Diabetes","volume":"45","author":"Balci","year":"2020","journal-title":"Turk J Biochem-Turk Biyokim Derg"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/srep32268","article-title":"Up-Regulation of miR-98 and Unraveling Regulatory Mechanisms in Gestational Diabetes Mellitus","volume":"6","author":"Cao","year":"2016","journal-title":"Sci Rep"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13317","article-title":"Plasma microRNA-16-5p, -17-5p and -20a-5p: Novel Diagnostic Biomarkers for Gestational Diabetes Mellitus","volume":"43","author":"Cao","year":"2017","journal-title":"J Obstet Gynaecol Res"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1159\/000495319","article-title":"Integrated Transcriptome Sequencing Analysis Reveals Role of miR-138-5p\/ TBL1X in Placenta From Gestational Diabetes Mellitus","volume":"51","author":"Ding","year":"2018","journal-title":"Cell Physiol Biochem"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-020-00618-8","article-title":"MicroRNA-33a-5p Sponges to Inhibit Pancreatic \u03b2-Cell Function in Gestational Diabetes Mellitus LncRNA DANCR","volume":"18","author":"Feng","year":"2020","journal-title":"Reprod Biol Endocrinol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.304730","article-title":"Gestational Diabetes Mellitus Impairs Fetal Endothelial Cell Functions Through a Mechanism Involving microRNA-101 and Histone Methyltransferase Enhancer of Zester Homolog-2","volume":"35","author":"Floris","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-02693","article-title":"miRNA Profiles in Extracellular Vesicles From Serum Early in Pregnancies Complicated by Gestational Diabetes Mellitus","volume":"104","author":"Gillet","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.17179\/excli2017-491","article-title":"miR-494 Protects Pancreatic \u03b2-Cell Function by Targeting PTEN in Gestational Diabetes Mellitus","volume":"16","author":"He","year":"2017","journal-title":"Exp Clin Sci J"},{"key":"B40","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.preghy.2019.04.004","article-title":"Differential Expression of Candidate Circulating microRNAs in Maternal Blood Leukocytes of the Patients With Preeclampsia and Gestational Diabetes Mellitus","volume":"17","author":"Hocaoglu","year":"2019","journal-title":"Pregnancy Hypertens"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2020.1843620","article-title":"Identification of Mir-16-5p and Mir-155-5p Micrornas Differentially Expressed in Circulating Leukocytes of Pregnant Women With Polycystic Ovary Syndrome and Gestational Diabetes","volume":"37","author":"Hocaoglu","year":"2020","journal-title":"Gynecol Endocrinol"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2020.4626","article-title":"Placental Exosomes Isolated From Urine of Patients With Gestational Diabetes Exhibit a Differential Profile Expression of microRNAs Across Gestation","volume":"46","author":"Herrera-Van Oostdam","year":"2020","journal-title":"Int J Mol Med"},{"key":"B43","doi-asserted-by":"publisher","first-page":"145","DOI":"10.3892\/etm.2020.9576","article-title":"Diagnostic Value of Candidate Noncoding RNAs in Leukocytes of Patients With Gestational Diabetes Mellitus","volume":"21","author":"Hu","year":"2021","journal-title":"Exp Ther Med"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1515\/med-2021-0247","article-title":"miR-377 Inhibition Enhances the Survival of Trophoblast Cells via Upregulation of FNDC5 in Gestational Diabetes Mellitus","volume":"16","author":"Hua","year":"2021","journal-title":"Open Med Wars Pol"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2017.08.003","article-title":"Central Nervous System Development-Related microRNAs Levels Increase in the Serum of Gestational Diabetic Women During the First Trimester of Pregnancy","volume":"130","author":"Lamadrid-Romero","year":"2018","journal-title":"Neurosci Res"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1159\/000430349","article-title":"MicroRNA Signature in Gestational Diabetes Mellitus Associated With Risk of Macrosomia","volume":"37","author":"Li","year":"2015","journal-title":"Cell Physiol Biochem"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1461","article-title":"microRNA-96 Protects Pancreatic \u03b2-Cell Function by Targeting PAK1 in Gestational Diabetes Mellitus","volume":"44","author":"Li","year":"2018","journal-title":"BioFactors"},{"key":"B48","doi-asserted-by":"publisher","first-page":"230","DOI":"10.3892\/etm.2021.9661","article-title":"MicroRNA-1323 Serves as a Biomarker in Gestational Diabetes Mellitus and Aggravates High Glucose-Induced Inhibition of Trophoblast Cell Viability by Suppressing TP53INP1","volume":"21","author":"Liu","year":"2021","journal-title":"Exp Ther Med"},{"key":"B49","doi-asserted-by":"publisher","first-page":"3343","DOI":"10.3390\/ijms20133343","article-title":"Unhealthy Levels of Phthalates and Bisphenol a in Mexican Pregnant Women With Gestational Diabetes and Its Association to Altered Expression of miRNAs Involved With Metabolic Disease","volume":"20","author":"Mart\u00ednez-Ibarra","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.12.035","article-title":"Conserved Seed Pairing, Often Flanked by Adenosines, Indicates That Thousands of Human Genes Are microRNA Targets","volume":"120","author":"Lewis","year":"2005","journal-title":"Cell"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1042\/CS20180487","article-title":"Human Placental Exosomes in Gestational Diabetes Mellitus Carry a Specific Set of miRNAs Associated With Skeletal Muscle Insulin Sensitivity","volume":"132","author":"Nair","year":"2018","journal-title":"Clin Sci"},{"key":"B52","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1186\/s12967-021-02999-9","article-title":"Extracellular Vesicle-Associated miRNAs Are an Adaptive Response to Gestational Diabetes Mellitus","volume":"19","author":"Nair","year":"2021","journal-title":"J Transl Med"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2018.03.002","article-title":"High Glucose Induces Dysfunction of Human Umbilical Vein Endothelial Cells by Upregulating miR-137 in Gestational Diabetes Mellitus","volume":"118","author":"Peng","year":"2018","journal-title":"Microvasc Res"},{"key":"B54","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1038\/s41598-020-57838-6","article-title":"Circulating miR-330-3p in Late Pregnancy Is Associated With Pregnancy Outcomes Among Lean Women With GDM","volume":"10","author":"Pfeiffer","year":"2020","journal-title":"Sci Rep"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1007\/s40291-018-0325-0","article-title":"Decreased Expression of Circulating miR-20a-5p in South African Women With Gestational Diabetes Mellitus","volume":"22","author":"Pheiffer","year":"2018","journal-title":"Mol Diagn Ther"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00345","article-title":"Circulating microRNA (miRNA) Expression Profiling in Plasma of Patients With Gestational Diabetes Mellitus Reveals Upregulation of miRNA miR-330-3p","volume":"8","author":"Sebastiani","year":"2017","journal-title":"Front Endocrinol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.5603\/GP.a2021.0077","article-title":"miR-181d Promotes Pancreatic Beta Cell Dysfunction by Targeting IRS2 in Gestational Diabetes Mellitus","volume":"92","author":"Shen","year":"2021","journal-title":"Ginekol Pol"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1210\/en.2013-2046","article-title":"Differential Expression of microRNAs in Omental Adipose Tissue From Gestational Diabetes Mellitus Subjects Reveals miR-222 as a Regulator of ER\u03b1 Expression in Estrogen-Induced Insulin Resistance","volume":"155","author":"Shi","year":"2014","journal-title":"Endocrinology"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1007\/s10528-021-10064-9","article-title":"MiR-34b-3p Impaired HUVECs Viability and Migration via Targeting PDK1 in an in Vitro Model of Gestational Diabetes Mellitus","volume":"59","author":"Song","year":"2021","journal-title":"Biochem Genet"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-19200-9","article-title":"Maternal Whole Blood Cell miRNA-340 Is Elevated in Gestational Diabetes and Inversely Regulated by Glucose and Insulin","volume":"8","author":"Stirm","year":"2018","journal-title":"Sci Rep"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00169","article-title":"The miRNA-29b Is Downregulated in Placenta During Gestational Diabetes Mellitus and May Alter Placenta Development by Regulating Trophoblast Migration and Invasion Through a HIF3A-Dependent Mechanism","volume":"11","author":"Sun","year":"2020","journal-title":"Front Endocrinol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"170","DOI":"10.3390\/cells10010170","article-title":"The DALI Core Investigator Group. the Predictive Value of miR-16, -29a and -134 for Early Identification of Gestational Diabetes: A Nested Analysis of the DALI Cohort","volume":"10","author":"S\u00f8rensen","year":"2021","journal-title":"Cells"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2018.06.004","article-title":"MicroRNA Profiling of Second Trimester Maternal Plasma Shows Upregulation of miR-195-5p in Patients With Gestational Diabetes","volume":"672","author":"Tagoma","year":"2018","journal-title":"Gene"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2017.07.024","article-title":"Circulating Early- and Mid-Pregnancy microRNAs and Risk of Gestational Diabetes","volume":"132","author":"Wander","year":"2017","journal-title":"Diabetes Res Clin Pract"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27468","article-title":"Dysregulation of microRNA-657 influences inflammatory response via targeting interleukin-37 in gestational diabetes mellitus: WANG et al","volume":"234","author":"Wang","year":"2018","journal-title":"J Cell Physiol"},{"key":"B66","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1007\/s13205-019-1952-9","article-title":"Role of Cell Free microRNA-19a and microRNA-19b in Gestational Diabetes Mellitus Patients","volume":"9","author":"Wang","year":"2019","journal-title":"3 Biotech"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4851214","article-title":"miR-657 Promotes Macrophage Polarization Toward M1 by Targeting FAM46C in Gestational Diabetes Mellitus","author":"Wang","year":"2019","journal-title":"Mediators Inflamm"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23325","article-title":"Serum miR-195-5p Is Upregulated in Gestational Diabetes Mellitus","volume":"34","author":"Wang","year":"2020","journal-title":"J Clin Lab Anal"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2021.1908990","article-title":"Circulating miRNAs miR-574-5p and miR-3135b Are Potential Metabolic Regulators for Serum Lipids and Blood Glucose in Gestational Diabetes Mellitus","volume":"37","author":"Wang","year":"2021","journal-title":"Gynecol Endocrinol"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1080\/10799893.2020.1810705","article-title":"MiR-190b Impedes Pancreatic \u03b2 Cell Proliferation and Insulin Secretion by Targeting NKX6-1 and May Associate to Gestational Diabetes Mellitus","volume":"41","author":"Wang","year":"2021","journal-title":"J Recept Signal Transduct Res"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6696636","article-title":"MiR-6869-5p Induces M2 Polarization by Regulating PTPRO in Gestational Diabetes Mellitus","volume":"2021","author":"Wang","year":"2021","journal-title":"Mediators Inflamm"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.18388\/abp.2020_5389","article-title":"miR-520h Inhibits Cell Survival by Targeting mTOR in Gestational Diabetes Mellitus","volume":"68","author":"Wen","year":"2021","journal-title":"Acta Biochim Pol"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1111\/jog.14249","article-title":"MiR-330-3p Contributes to INS-1 Cell Dysfunction by Targeting Glucokinase in Gestational Diabetes Mellitus","volume":"46","author":"Xiao","year":"2020","journal-title":"J Obstet Gynaecol Res"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.17179\/excli2017-738","article-title":"microRNA-503 Contribute to Pancreatic Beta Cell Dysfunction by Targeting the mTOR Pathway in Gestational Diabetes Mellitus","volume":"16","author":"Xu","year":"2017","journal-title":"EXCLI J"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-19-0206","article-title":"Early Diagnosis of Gestational Diabetes Mellitus Using Circulating microRNAs","volume":"181","author":"Yoffe","year":"2019","journal-title":"Eur J Endocrinol"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000025808","article-title":"miR-96-5p: A Potential Diagnostic Marker for Gestational Diabetes Mellitus","volume":"100","author":"Yu","year":"2021","journal-title":"Medicine (Baltimore)"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13493","article-title":"Diagnostic Value of Dysregulated Microribonucleic Acids in the Placenta and Circulating Exosomes in Gestational Diabetes Mellitus","volume":"12","author":"Zhang","year":"2021","journal-title":"J Diabetes Investig"},{"key":"B78","doi-asserted-by":"publisher","first-page":"107959","DOI":"10.1016\/j.jdiacomp.2021.107959","article-title":"Down-Regulation of microRNA-30d-5p Is Associated With Gestational Diabetes Mellitus by Targeting RAB8A","volume":"35","author":"Zhang","year":"2021","journal-title":"J Diabetes Complications"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023925","article-title":"Early Second-Trimester Serum miRNA Profiling Predicts Gestational Diabetes Mellitus","volume":"6","author":"Zhao","year":"2011","journal-title":"PloS One"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2014.2058","article-title":"MicroRNA-518d Regulates PPAR\u03b1 Protein Expression in the Placentas of Females With Gestational Diabetes Mellitus","volume":"9","author":"Zhao","year":"2014","journal-title":"Mol Med Rep"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_202001_20062","article-title":"Dysregulation of microRNA-770-5p Influences Pancreatic-\u03b2-Cell Function by Targeting TP53 Regulated Inhibitor of Apoptosis 1 in Gestational Diabetes Mellitus","volume":"24","author":"Zhang","year":"2020","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-019-0899-9","article-title":"miR-132 Serves as a Diagnostic Biomarker in Gestational Diabetes Mellitus and Its Regulatory Effect on Trophoblast Cell Viability","volume":"14","author":"Zhou","year":"2019","journal-title":"Diagn Pathol"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2015.01.010","article-title":"Profiling Maternal Plasma microRNA Expression in Early Pregnancy to Predict Gestational Diabetes Mellitus","volume":"130","author":"Zhu","year":"2015","journal-title":"Int J Gynecol Obstet"},{"key":"B84","doi-asserted-by":"crossref","DOI":"10.1002\/9781444324808.ch53","article-title":"Diabetes in Pregnancy","volume-title":"Textbook of Diabetes","author":"Dornhorst","year":"2010"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2014.09.006","article-title":"Saturated Fatty Acid-Induced miR-195 Impairs Insulin Signaling and Glycogen Metabolism in HepG2 Cells","volume":"588","author":"Yang","year":"2014","journal-title":"FEBS Lett"},{"key":"B86","doi-asserted-by":"publisher","first-page":"8413","DOI":"10.3390\/ijms21218413","article-title":"Association Analysis in Children Born from Normal and Complicated Pregnancies-Cardiovascular Disease Associated microRNAs and the Incidence of Prehypertension\/Hypertension, Overweight\/Obesity, Valve Problems and Heart Defects","volume":"21","author":"Hromadnikova","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00191","article-title":"Metformin and Its Benefits for Various Diseases","volume":"11","author":"Lv","year":"2020","journal-title":"Front Endocrinol"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.5603\/GP.2019.0096","article-title":"The Relationship Between IGF1 and the Expression Spectrum of miRNA in the Placenta of Preeclampsia Patients","volume":"90","author":"He","year":"2019","journal-title":"Ginekol Pol"},{"key":"B89","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1186\/1756-0500-6-491","article-title":"Identifying Common and Specific microRNAs Expressed in Peripheral Blood Mononuclear Cell of Type 1, Type 2, and Gestational Diabetes Mellitus Patients","volume":"6","author":"Collares","year":"2013","journal-title":"BMC Res Notes"},{"key":"B90","article-title":"Placental microRNA Expression Patterns in Pregestational Diabetes and Identification of Specific Potential Biomarkers","volume":"161","author":"Ibarra","year":"2018","journal-title":"Diabetol"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1007\/s40291-019-00404-2","article-title":"MicroRNA Profiling in HIV-Infected South African Women with Gestational Diabetes Mellitus","volume":"23","author":"Pheiffer","year":"2019","journal-title":"Mol Diagn Ther"},{"key":"B92","doi-asserted-by":"publisher","first-page":"100406","DOI":"10.1016\/j.cpcardiol.2018.12.003","article-title":"Aging, MicroRNAs, and Heart Failure","volume":"45","author":"Florio","year":"2020","journal-title":"Curr Probl Cardiol"},{"key":"B93","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/ng1536","article-title":"Combinatorial microRNA Target Predictions","volume":"37","author":"Huang","year":"2005","journal-title":"Nat Genet"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-3302","article-title":"The Prognostic Value of microRNAs Varies With Patient Race\/ethnicity and Stage of Colorectal Cancer","volume":"19","author":"Bovell","year":"2013","journal-title":"Clin Cancer Res Off J Am Assoc Cancer Res"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2021.03.070","article-title":"Sex Differences in miRNA Expression and Cardiometabolic Risk Factors in Hispanic Adolescents With Obesity","volume":"235","author":"Karere","year":"2021","journal-title":"J Pediatr"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3198","article-title":"MicroRNA Profiling: Approaches and Considerations","volume":"13","author":"Pritchard","year":"2012","journal-title":"Nat Rev Genet"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041561","article-title":"Comparing the MicroRNA Spectrum Between Serum and Plasma","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS ONE"},{"key":"B98","doi-asserted-by":"publisher","first-page":"1080157","DOI":"10.1155\/2017\/1080157","article-title":"MicroRNA Expression Varies according to Glucose Tolerance, Measurement Platform, and Biological Source","volume":"2017","author":"Dias","year":"2017","journal-title":"BioMed Res Int"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1038\/ng1536","article-title":"Combinatorial microRNA Target Predictions","volume":"37","author":"Krek","year":"2005","journal-title":"Nat Genet"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.12.035","article-title":"Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes Are microRNA Targets","volume":"120","author":"Lewis","year":"2005","journal-title":"Cell"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.892587\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T06:43:49Z","timestamp":1658731429000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.892587\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,25]]},"references-count":100,"alternative-id":["10.3389\/fendo.2022.892587"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2022.892587","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,25]]},"article-number":"892587"}}