{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T05:52:12Z","timestamp":1757310732490,"version":"3.41.2"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T00:00:00Z","timestamp":1651795200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"Purpose<\/jats:title>Poor adherence to recombinant human growth hormone (r-hGH) treatment presents a significant barrier to achieving optimal growth outcomes. It is important to identify and address the treatment adherence-related needs of children prescribed r-hGH treatment, and develop new approaches to improve adherence. We aimed to measure the impact of the TUITEK\u00ae<\/jats:sup> patient support programme, a multi-component personalized service intervention, on caregivers\u2019 knowledge, beliefs, and perceptions of short stature and adherence to its treatment.<\/jats:p><\/jats:sec>Patients and Methods<\/jats:title>The evaluation of the TUITEK\u00ae<\/jats:sup> patient support programme was conducted among 31 caregivers of children with short stature and receiving r-hGH treatment via<\/jats:italic> the easypod\u2122 auto-injector device in Taiwan. Caregivers within the \u2018high risk\u2019 category for knowledge, beliefs and perception factors influencing adherence to r-hGH treatment (disease and treatment coherence, emotional burden, self-administration, and treatment-related anxiety) were identified via<\/jats:italic> the TUITEK\u00ae<\/jats:sup> personalization questionnaire and followed up with bi-weekly telephone calls by a nurse practitioner over a 3-month period. A Wilcoxon signed-rank test was used to compare changes in questionnaire-based scoring patterns between baseline and follow-up.<\/jats:p><\/jats:sec>Results<\/jats:title>Between baseline and follow-up, the percentage of caregivers scoring as \u2018high risk\u2019 for emotional burden reduced by 37%; there was an improvement in confidence of self-administration by 57% and the percentage of caregivers scoring as \u2018high risk\u2019 for treatment-related anxiety reduced by 52%. At follow-up, all caregivers classified as \u2018high risk\u2019 within the disease and treatment coherence item at baseline moved into the \u2018low risk\u2019 category. Statistically significant changes in questionnaire scores between baseline and follow-up for disease and treatment understanding, emotional burden, self-administration, and treatment-related anxiety were also observed.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>These findings indicate that the TUITEK\u00ae<\/jats:sup> patient support programme can positively address disease and treatment-related barriers amongst caregivers regarding optimal adherence of their children to r-hGH treatment, which has the potential to positively impact on adherence levels and patient clinical health outcomes.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2022.897956","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T06:39:33Z","timestamp":1651819173000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Investigating the Impact of the TUITEK\u00ae Patient Support Programme, Designed to Support Caregivers of Children Prescribed Recombinant Human Growth Hormone Treatment in Taiwan"],"prefix":"10.3389","volume":"13","author":[{"given":"Pen-Hua","family":"Su","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumaira","family":"Malik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amrit","family":"Jheeta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen-Fan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-Huei","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekaterina","family":"Koledova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selina","family":"Graham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1159\/000350251","article-title":"Understanding the Growth Hormone Therapy Adherence Paradigm: A Systematic Review","volume":"79","author":"Fisher","year":"2013","journal-title":"Horm Res Paediatr"},{"volume-title":"Human Growth Hormone (Somatropin) for the Treatment of Growth Failure in Children","year":"2010","key":"B2"},{"key":"B3","doi-asserted-by":"publisher","first-page":"93","DOI":"10.2165\/00148581-200406020-00003","article-title":"Growth Hormone Treatment in Children: Review of Safety and Efficacy","volume":"6","author":"Harris","year":"2004","journal-title":"Paediatr Drugs"},{"key":"B4","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.ecl.2009.06.006","article-title":"Growth Hormone: The Expansion of Available Products and Indications","volume":"38","author":"Franklin","year":"2009","journal-title":"Endocrinol Metab Clin North Am"},{"key":"B5","doi-asserted-by":"publisher","first-page":"46","DOI":"10.4158\/EP13194.OR","article-title":"Adherence to Growth Hormone Therapy: Results of a Multicenter Study","volume":"20","author":"Ayd\u0131n","year":"2014","journal-title":"Endocr Pract"},{"key":"B6","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/1687-9856-2014-15","article-title":"Growth Hormone Significantly Increases the Adult Height of Children With Idiopathic Short Stature: Comparison of Subgroups and Benefit","volume":"2014","author":"Sotos","year":"2014","journal-title":"Int J Pediatr Endocrinol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2011.09.004","article-title":"The Benefits of Growth Hormone Therapy in Patients With Turner Syndrome, Noonan Syndrome and Children Born Small for Gestational Age. 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