{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T18:42:36Z","timestamp":1777574556159,"version":"3.51.4"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000848, 81900810, 82170866"],"award-info":[{"award-number":["82000848, 81900810, 82170866"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of\u00a0Hunan Province","doi-asserted-by":"publisher","award":["2019JJ40262"],"award-info":[{"award-number":["2019JJ40262"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Non-alcoholic fatty liver disease (NAFLD), hallmarked by liver steatosis, is becoming a global concern, but effective and safe drugs for NAFLD are still lacking at present. Parathyroid hormone (PTH), the only FDA-approved anabolic treatment for osteoporosis, is important in calcium-phosphate homeostasis. However, little is known about its potential therapeutic effects on other diseases. Here, we report that intermittent administration of PTH ameliorated non-alcoholic liver steatosis in diet-induced obese (DIO) mice and db\/db mice, as well as fasting-induced hepatic steatosis. <jats:italic>In vitro<\/jats:italic>, PTH inhibits palmitic acid-induced intracellular lipid accumulation in a parathyroid hormone 1 receptor (PTH1R)-dependent manner. Mechanistically, PTH upregulates the expression of genes involved in lipid \u03b2-oxidation and suppresses the expression of genes related to lipid uptake and <jats:italic>de novo<\/jats:italic> lipogenesis by activating the cAMP\/PKA\/CREB pathway. Taken together, our current finding proposes a new therapeutic role of PTH on NAFLD.<\/jats:p>","DOI":"10.3389\/fendo.2022.899731","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T07:10:47Z","timestamp":1660720247000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Parathyroid hormone alleviates non-alcoholic liver steatosis via activating the hepatic cAMP\/PKA\/CREB 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