{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:56:13Z","timestamp":1792518973428,"version":"4.5.0"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:00:00Z","timestamp":1657756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>FGF21 pharmacological treatment reverses fatty liver and lowers serum triglyceride concentration but FGF21 serum level is increased in hepatic steatosis. FGF21 secretion is induced by thyroid hormones <jats:italic>in vitro<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To determine the influence of thyroid hormones and metabolic changes secondary to thyroid dysfunction on FGF21 secretion in humans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This was a case-control study. 82 hyperthyroid and 15 hypothyroid patients were recruited together with 25 healthy controls. Of those with hyperthyroidism, 56 received radioiodine treatment and 42 of them achieved hypothyroidism and then euthyroidism within one year following therapy. Radioiodine-induced hypothyroidism developed abruptly within a six week interval between clinic visits. FGF21 serum levels were determined with an ELISA method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum FGF21 levels did not differ in hyper- and hypothyroid patients in comparison to controls [median 103.25 (interquartile range, 60.90-189.48) and 86.10 (54.05-251.02) vs 85.20 (58.00-116.80) pg\/mL P=0.200 and 0.503, respectively]. In hyperthyroid patients treated with radioiodine, serum FGF21 levels increased significantly in rapid-onset hypothyroidism in comparison to the hyperthyroid and euthyroid phase [median 160.55 (interquartile range, 92.48 - 259.35) vs 119.55 (67.78-192.32) and 104.43 (55.93-231.93) pg\/mL, P=0.034 and 0.033, respectively]. The rising serum FGF21 level correlated positively with serum triglycerides (Spearman coefficient rs=0.36, P=0.017) and inversely with serum SHBG (rs=-0.41, P=0.007), but did not correlate with thyroid hormone levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There was a transient increase in FGF21 serum level during rapid-onset hypothyroidism following radioiodine treatment. There was no association between FGF21 serum level and thyroid hormones. In radioiodine-induced hypothyroidism, the rising serum FGF21 concentration correlated positively with rising serum triglycerides and negatively with falling SHBG, reflecting increased hepatic lipogenesis.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2022.900034","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T05:45:48Z","timestamp":1657777548000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["FGF21 Is Released During Increased Lipogenesis State Following Rapid-Onset Radioiodine-Induced Hypothyroidism"],"prefix":"10.3389","volume":"13","author":[{"given":"Ewa","family":"Szczepa\u0144ska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Glinicki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Zgliczy\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jadwiga","family":"S\u0142owi\u0144ska-Srzednicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Jastrz\u0119bska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Gietka-Czernel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0816","article-title":"Fibroblast Growth Factor 21 Corrects Obesity in Mice","volume":"149","author":"Coskun","year":"2008","journal-title":"Endocrinology"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.2337\/db08-0392","article-title":"Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet- Induced Obese Mice","volume":"58","author":"Xu","year":"2009","journal-title":"Diabetes"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.02.001","article-title":"A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in non-Human Primates and Type 2 Diabetic Subjects","volume":"23","author":"Talukdar","year":"2016","journal-title":"Cell Metab"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C110.107375","article-title":"Thyroid Hormone Regulates Hepatic Expression of Fibroblast Growth Factor 21 in a Ppar\u03b1-Dependent Manner","volume":"285","author":"Adams","year":"2010","journal-title":"J Biol Chem"},{"key":"B5","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1530\/JOE-14-0440","article-title":"Thyroid Hormone Receptor Regulates Most Genes Independently of Fibroblast Growth Factor 21 in Liver","volume":"224","author":"Zhang","year":"2015","journal-title":"J Endocrinol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M051664","article-title":"Thyroid Hormone Reduces PCSK9 and Stimulates Bile Acid Synthesis in Humans","volume":"55","author":"Bonde","year":"2014","journal-title":"J Lipid Res"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-1797","article-title":"Elevated Serum Fibroblast Growth Factor 21 Levels in Patients With Hyperthyroidism","volume":"100","author":"Xiao","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"B8","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4614-0887-1_1","article-title":"The Structural Biology of the FGF19 Subfamily","volume-title":"Endocrine FGFs and Klothos. 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