{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:09:18Z","timestamp":1785499758543,"version":"3.56.0"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T00:00:00Z","timestamp":1662595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the birth prevalence of perinatal stroke in term born infants at our high-volume delivery center and assess the frequency of both gross and histologic placental pathologies associated with perinatal stroke using the Amsterdam Placental Workshop Group Consensus Statement guidelines and definitions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A single-center retrospective cohort study spanning 2010-2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 129,759 live births at Parkland Hospital during the study period and a total of 18 term born infants leading to a birth prevalence of 1 in 6,829 infants. Perinatal risk factors were found in all but one patient, and 74% presented with seizures. Pathologic placental examination was available in 56% of the cohort and only one patient had normal placental examination. Acute histologic chorioamnionitis was described in five placentas (50%) and an additional two had isolated umbilical and\/or chorionic plate vasculitis with or without funisitis compared to a rate of 28% with acute inflammation in a Control group. Chronic inflammation in the form of villitis of unknown etiology was described in three of the acutely inflamed placentas and was high-grade in each of those while none of the placentas from our Control group showed evidence of any chronic lesion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both acute and chronic placental inflammation are common in perinatal stroke; placental examination should be considered an essential component to the diagnostic workup.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2022.920680","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T05:08:25Z","timestamp":1662613705000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Placental pathologic lesions associated with stroke in term neonates"],"prefix":"10.3389","volume":"13","author":[{"given":"Rachel L.","family":"Leon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay","family":"Kalvacherla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle Machie","family":"Andrews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran N.","family":"Mir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina F.","family":"Chalak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000183","article-title":"Management of stroke in neonates and children: A scientific statement from the American heart Association\/American stroke association","volume":"50","author":"Ferriero","year":"2019","journal-title":"Stroke"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0803.2011.00510.x","article-title":"Failure to impact prevalence of arterial ischemic stroke in pediatric cardiac patients over three decades","volume":"6","author":"Hoffman","year":"2011","journal-title":"Congenital Heart disease"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12555","article-title":"Neonatal stroke: a review of the current evidence on epidemiology, pathogenesis, diagnostics and therapeutic options","volume":"103","author":"van der Aa","year":"2014","journal-title":"Acta paediatrica"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-1148","article-title":"Symptomatic neonatal arterial ischemic stroke: the international pediatric stroke study","volume":"128","author":"Kirton","year":"2011","journal-title":"Pediatrics"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2021.06.017","article-title":"Neonatal stroke: Clinical characteristics and neurodevelopmental outcomes","volume":"63","author":"Elgendy","year":"2022","journal-title":"Pediatr neonatology"},{"key":"B6","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.jpeds.2016.01.069","article-title":"Multimodal outcome at 7 years of age after neonatal arterial ischemic stroke","volume":"172","author":"Chabrier","year":"2016","journal-title":"J pediatrics"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2014.01.006","article-title":"Quality of life and functional outcome in early school-aged children after neonatal stroke: a prospective cohort study","volume":"18","author":"Darteyre","year":"2014","journal-title":"Eur J paediatric Neurol EJPN Off J Eur Paediatric Neurol Society"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22950","article-title":"Long term motor function after neonatal stroke: Lesion localization above all","volume":"36","author":"Dinomais","year":"2015","journal-title":"Hum Brain mapping"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200108093450604","article-title":"Cerebral sinovenous thrombosis in children","volume":"345","author":"deVeber","year":"2001","journal-title":"New Engl J Med"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.3.405","article-title":"Cerebral sinovenous thrombosis in the neonate","volume":"63","author":"Fitzgerald","year":"2006","journal-title":"Arch neurol."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2010.03722.x","article-title":"Cerebral sinus venous thrombosis in Swiss children","volume":"52","author":"Grunt","year":"2010","journal-title":"Dev Med Child neurol."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.106.479311","article-title":"Maternal and infant characteristics associated with perinatal arterial stroke in the preterm infant","volume":"38","author":"Benders","year":"2007","journal-title":"Stroke"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-304068","article-title":"Haemorrhagic stroke in term and late preterm neonates","volume":"99","author":"Bruno","year":"2014","journal-title":"Arch Dis childhood Fetal neonatal edition"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2009.03.030","article-title":"Perioperative stroke in infants undergoing open heart operations for congenital heart disease","volume":"88","author":"Chen","year":"2009","journal-title":"Ann Thorac surgery"},{"key":"B15","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.pediatrneurol.2007.04.007","article-title":"Risk factors for perinatal arterial stroke: a study of 60 mother-child pairs","volume":"37","author":"Curry","year":"2007","journal-title":"Pediatr neurol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.10.2437","article-title":"Symptomatic ischemic stroke in full-term neonates : role of acquired and genetic prothrombotic risk factors","volume":"31","author":"Gunther","year":"2000","journal-title":"Stroke"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.483743","article-title":"Acutely and retrospectively diagnosed perinatal stroke: a population-based study","volume":"38","author":"Laugesaar","year":"2007","journal-title":"Stroke"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0336","article-title":"Ischemic perinatal stroke: summary of a workshop sponsored by the national institute of child health and human development and the national institute of neurological disorders and stroke","volume":"120","author":"Raju","year":"2007","journal-title":"Pediatrics"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-3896","article-title":"Sagittal sinus compression is associated with neonatal cerebral sinovenous thrombosis","volume":"128","author":"Tan","year":"2011","journal-title":"Pediatrics"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000000077","article-title":"Diagnosis and acute management of perinatal arterial ischemic stroke","volume":"4","author":"Armstrong-Wells","year":"2014","journal-title":"Neurol Clin practice"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2009.05.004","article-title":"Obstetrical and neonatal characteristics vary with birthweight in a cohort of 100 term newborns with symptomatic arterial ischemic stroke","volume":"14","author":"Chabrier","year":"2010","journal-title":"Eur J paediatric Neurol EJPN Off J Eur Paediatric Neurol Society"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(18)30173-1","article-title":"Perinatal stroke: mechanisms, management, and outcomes of early cerebrovascular brain injury","volume":"2","author":"Dunbar","year":"2018","journal-title":"Lancet Child Adolesc Health"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2019.02.013","article-title":"Perinatal stroke syndromes: Similarities and diversities in aetiology, outcome and management","volume":"23","author":"Fluss","year":"2019","journal-title":"Eur J paediatric Neurol EJPN Off J Eur Paediatric Neurol Society"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-019-0715-y","article-title":"Impact of multiple placental pathologies on neonatal death, bronchopulmonary dysplasia, and neurodevelopmental impairment in preterm infants","volume":"87","author":"Mir","year":"2020","journal-title":"Pediatr Res"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-021-01521-7","article-title":"Neuroplacentology in congenital heart disease: placental connections to neurodevelopmental outcomes","volume":"91","author":"Leon","year":"2022","journal-title":"Pediatr Res"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.placenta.2018.07.006","article-title":"Fetal-placental crosstalk occurs through fetal cytokine synthesis and placental clearance","volume":"69","author":"Mir","year":"2018","journal-title":"Placenta"},{"key":"B27","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/1471-2431-13-59","article-title":"A systematic review and meta-analysis to revise the fenton growth chart for preterm infants","volume":"13","author":"Fenton","year":"2013","journal-title":"BMC Pediatr"},{"key":"B28","doi-asserted-by":"publisher","first-page":"698","DOI":"10.5858\/arpa.2015-0225-CC","article-title":"Sampling and definitions of placental lesions: Amsterdam placental workshop group consensus statement","volume":"140","author":"Khong","year":"2016","journal-title":"Arch Pathol Lab Med"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2009.07.007","article-title":"Diagnostic management of neonatal stroke","volume":"14","author":"Govaert","year":"2009","journal-title":"Semin fetal neonatal Med"},{"key":"B30","article-title":"Practice guideline for examination of the placenta: developed by the placental pathology practice guideline development task force of the college of American pathologists","volume":"121","author":"Langston","year":"1997","journal-title":"Arch Pathol Lab Med"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1177\/0883073820929214","article-title":"The role of the placenta in perinatal stroke: A systematic review","volume":"35","author":"Roy","year":"2020","journal-title":"J Child neurol."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-64239-4.00016-3","article-title":"Perinatal stroke","volume":"171","author":"Whitaker","year":"2020","journal-title":"Handb Clin Neurol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"e2020013201","DOI":"10.1542\/peds.2020-013201","article-title":"Population based birth prevalence of disease-specific perinatal stroke","volume":"146","author":"Dunbar","year":"2020","journal-title":"Pediatrics"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-0385","article-title":"Perinatal stroke in children with motor impairment: a population-based study","volume":"114","author":"Wu","year":"2004","journal-title":"Pediatrics"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.14347","article-title":"Risk factors for perinatal arterial ischaemic stroke: a large case-control study","volume":"62","author":"Sorg","year":"2020","journal-title":"Dev Med Child neurol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"e90106","DOI":"10.1371\/journal.pone.0090106","article-title":"Association between hypoxia and perinatal arterial ischemic stroke: a meta-analysis","volume":"9","author":"Luo","year":"2014","journal-title":"PLoS One"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-1490","article-title":"Placental pathology in neonatal stroke","volume":"127","author":"Elbers","year":"2011","journal-title":"Pediatrics"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.14375","article-title":"Perinatal inflammation and placental programming of neonatal stroke","volume":"62","author":"Chabrier","year":"2020","journal-title":"Dev Med Child neurol."},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2022.05.038","article-title":"Placental vascular malperfusion lesions in fetal congenital heart disease","author":"Leon","year":"2022","journal-title":"Am J Obstet Gynecol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2014.41","article-title":"Mechanisms of perinatal arterial ischemic stroke","volume":"34","author":"Fernandez-Lopez","year":"2014","journal-title":"J Cereb Blood Flow Metab Off J Int Soc Cereb Blood Flow Metab"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010309","article-title":"Association of neonatal inflammatory markers and perinatal stroke subtypes","volume":"95","author":"Mineyko","year":"2020","journal-title":"Neurology"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.783153","article-title":"The incidence and characteristics of perinatal stroke in Beijing: A multicenter study","volume":"10","author":"Xia","year":"2022","journal-title":"Front Public Health"},{"key":"B43","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.mri.2021.03.007","article-title":"Intravoxel incoherent motion MR imaging analysis for diagnosis of placenta accrete spectrum disorders: A pilot feasibility study","volume":"80","author":"Leon","year":"2021","journal-title":"Magn Reson Imaging"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-018-4213-x","article-title":"A retrospective segmentation analysis of placental volume by magnetic resonance imaging from first trimester to term gestation","volume":"48","author":"Leon","year":"2018","journal-title":"Pediatr radiol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"4137","DOI":"10.1038\/s41598-019-40894-y","article-title":"Placental pathology and neuroimaging correlates in neonates with congenital heart disease","volume":"9","author":"Schlatterer","year":"2019","journal-title":"Sci Rep"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1113\/JP281002","article-title":"An MRI approach to assess placental function in healthy humans and sheep","volume":"599","author":"Saini","year":"2021","journal-title":"J Physiol"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.920680\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T05:08:35Z","timestamp":1662613715000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.920680\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,8]]},"references-count":46,"alternative-id":["10.3389\/fendo.2022.920680"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2022.920680","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,8]]},"article-number":"920680"}}