{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T10:16:57Z","timestamp":1783937817524,"version":"3.55.0"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009687","name":"Uniwersytet Medyczny im. Piast\u00f3w Slaskich we Wroclawiu","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009687","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Down Syndrome (DS) is a chromosomal abnormality associated with a spectrum of cognitive and physical disabilities. Children with DS are exposed to both lower and excess body weight and follow distinct growth-curve patterns that deviate significantly from those of children without chromosomal defects. Anthropometric parameters are assessed in the pediatric population with the use of growth charts. The study is based on data from 411 children and adults with DS from Poland. Detailed information concerning children and online survey results were also analyzed. Centiles and standard deviation scores (SDS) of obtained anthropometric parameters were aligned with the data using the LMS method. The study aims to identify which type of growth chart (standard vs specialized) is a leading tool for earlier detection of developmental disorders in DS. The results obtained in the two types of growth charts differed. The advantage of the specialized growth charts over the standard ones cannot be unequivocally determined. Only the combination of both tools allows to detect the development disorders early in the broadest possible way.<\/jats:p>","DOI":"10.3389\/fendo.2022.928151","type":"journal-article","created":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T10:05:04Z","timestamp":1659693904000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["The best tool for the assessment of developmental disorders in children with down syndrome: comparison of standard and specialized growth charts - cross sectional study"],"prefix":"10.3389","volume":"13","author":[{"given":"Marta","family":"Hetman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Barg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.11.032","article-title":"A community cross-sectional survey of medical problems in 440 children with down syndrome in new york state","volume":"164","author":"Roizen","year":"2014","journal-title":"J Pediatr"},{"key":"B2","article-title":"Neurologia podr\u0119cznik dla student\u00f3w medycyny","author":"Kuzubski","year":"2014"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.06.013","article-title":"Current estimate of down syndrome population prevalence in the united states","volume":"163","author":"Presson","year":"2013","journal-title":"J Pediatr"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3148.2010.00593","article-title":"Assessment of prevalence of persons with down syndrome: A theory-based demographic model","volume":"24","author":"de Graaf","year":"2011","journal-title":"J Appl Res Intellect Disabil"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-1652","article-title":"Growth charts for children with down syndrome in the united states","volume":"136","author":"Zemel","year":"2015","journal-title":"Pediatrics"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.37366","article-title":"Down syndrome birth weight in England and Wales: Implications for clinical practice","author":"Morris","year":"2015","journal-title":"Am J Med Genet Part A"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5349","article-title":"Association of isolated short femur in the mid-trimester fetus with perinatal outcome","volume":"31","author":"Weisz","year":"2008","journal-title":"Ultrasound Obstetric Gynecol Off J Int Soc Ultrasound Obstetric Gynecol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1017\/S0003480001008508","article-title":"Mortality and cancer incidence in persons with down's syndrome, their parents and siblings","volume":"65","author":"Hermon","year":"2001","journal-title":"Ann Hum Genet"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1017\/s0012162205000319","article-title":"Mortality and causes of death in persons with down syndrome in California","volume":"47","author":"Day","year":"2005","journal-title":"Dev Med Child Neurol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-0886","article-title":"Prevalence of overweight in Dutch children with down syndrome","volume":"130","author":"van Gameren-Oosterom","year":"2012","journal-title":"Pediatrics"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/jir.12100","article-title":"Obesity and associated factors in adults with intellectual disability","volume":"58","author":"Hsieh","year":"2014","journal-title":"J Intellect Disabil Res JIDR"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3109\/00016348209156561","article-title":"Ultrasonic growth pattern of fetuses with chromosomal aberrations","volume":"61","author":"Kurjak","year":"1982","journal-title":"Acta Obstetric Gynecol Scandinavic"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.38165","article-title":"Neonatal characteristics and perinatal complications in neonates with down syndrome","volume":"173","author":"Ergaz-Shaltiel","year":"2017","journal-title":"Am J Med Genet"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2788.1996.800800.x","article-title":"Growth charts for children with down syndrome: 1 month to 18 years of age","volume":"81","author":"Cronk","year":"1998","journal-title":"Pediatrics"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1136\/adc.87.2.104","article-title":"A. new cross sectional stature, weight, and head circumference references for down's syndrome in the UK and republic of Ireland","volume":"87","author":"Styles","year":"2002","journal-title":"Arch Dis Childhood"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2788.1996.800800.x","article-title":"Growth curves of Dutch children with down's syndrome","volume":"40","author":"Cremers","year":"1996","journal-title":"J Intellect Disabil Res JIDR"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-0541","article-title":"Body composition and BMI growth charts in children with down syndrome","volume":"138","author":"Hatch-Stein","year":"2016","journal-title":"Pediatrics"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.je.2016.06.009","article-title":"Growth charts for Brazilian children with down syndrome: Birth to 20 years of age","volume":"27","author":"Bertapelli","year":"2017","journal-title":"J Epidemiol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20130081","article-title":"National growth charts for united Arab Emirates children with down syndrome from birth to 15 years of age","volume":"25","author":"Aburawi","year":"2015","journal-title":"J Epidemiol"},{"key":"B20","volume-title":"Anthropometric standardization reference manual","author":"Lohman","year":"2008"},{"key":"B21","volume-title":"LMSgrowth, a Microsoft excel add-in to access growth references based on the l method, version 2.69","author":"Pan","year":"2010"},{"key":"B22","first-page":"45","article-title":"The LMS method for constructing normalized growth standards","volume":"44","author":"Cole","year":"1990","journal-title":"Eur J Clin Nutr"},{"key":"B23","doi-asserted-by":"crossref","DOI":"10.1111\/j.2517-6161.1964.tb00553.x","article-title":"An analysis of transformation","volume":"26","author":"Box","year":"1964","journal-title":"J R Stat Soc"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1136\/adc.76.1.47","article-title":"Growth monitoring with the British 1990 growth reference","volume":"76","author":"Cole","year":"1997","journal-title":"Arch Dis Childhood"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1590\/s0103-05822014000100015","article-title":"Effects of two programs of exercise on body composition of adolescents with down syndrome","volume":"32","author":"Seron","year":"2014","journal-title":"Rev Paulist Pediatr Orgao Oficial Da Sociedade Pedia Sao Paulo"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6081.226","article-title":"Down's syndrome: an atheroma-free model","volume":"2","author":"Murdoch","year":"1997","journal-title":"Br Med J"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1002\/clc.20864","article-title":"Myocardial infarction in a patient with down syndrome: a case report and review of the literature","volume":"34","author":"Raina","year":"2011","journal-title":"Clin Cardiol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.6.705","article-title":"Mortality and cancer incidence among individuals with down syndrome","volume":"163","author":"Hill","year":"2003","journal-title":"Arch Internal Med"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1080\/13668250600999186","article-title":"Young people with down syndrome: a preliminary investigation of health knowledge and associated behaviours","volume":"31","author":"Jobling","year":"2006","journal-title":"J Intellect Dev Disabil"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1080\/08035250310007024","article-title":"Down syndrome and breastfeeding","volume":"92","author":"Pisacane","year":"2003","journal-title":"Acta Paedia (Oslo Norway 1992)"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605244","article-title":"Breastfeeding and early infection in the aetiology of childhood leukaemia in down syndrome","volume":"101","author":"Flores-Lujano","year":"2009","journal-title":"Br J Cancer"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(19)30400-6","article-title":"Nutritional challenges in children and adolescents with down syndrome","volume":"4","author":"Nordstr\u00f8m","year":"2020","journal-title":"Lancet Child Adolesc Health 2020"},{"key":"B33","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1111\/j.1469-8749.1996.tb12139.x","article-title":"& Friedman, b. swallow function in children with down syndrome: a retrospective study","volume":"38","author":"Frazier","year":"1996","journal-title":"Dev Med Child Neurol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1136\/adc.87.2.97","article-title":"Growth charts for down's syndrome from birth to 18 years of age","volume":"87","author":"Myrelid","year":"2002","journal-title":"Arch Dis Childhood"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1080\/08035250310004306","article-title":"Longitudinal growth and height velocity of Japanese children with down's syndrome","volume":"92","author":"Kimura","year":"2003","journal-title":"Acta Paedia (Oslo Norway 1992)"},{"key":"B36","doi-asserted-by":"publisher","first-page":"e31079","DOI":"10.1371\/journal.pone.0031079","article-title":"Healthy growth in children with down syndrome","volume":"7","author":"Van Gameren-Oosterom","year":"2021","journal-title":"PLoS One"},{"key":"B37","first-page":"59","article-title":"Disturbo della crescita nella sindrome de down: terapia con ormone della crescita [Growth disorders in down's syndrome: growth hormone treatment]","volume":"27","author":"Pallotti","year":"2002","journal-title":"Minerv Endocrinol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2009.01679.x","article-title":"Late effects of early growth hormone treatment in down syndrome","volume":"99","author":"Myrelid","year":"2010","journal-title":"Acta Paedia (Oslo Norway 1992)"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-16-0858","article-title":"Early thyroxine treatment in Down syndrome and thyroid function later in life","volume":"176","author":"Zwaveling-Soonawala","year":"2017","journal-title":"Eur J Endocrinol"},{"key":"B40","first-page":"85","article-title":"L-thyroxine therapy and growth processes in children with down syndrome","volume":"22","author":"Kowalczyk","year":"2013","journal-title":"Adv Clin Exp Med Off Organ Wroclaw Med Univ"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1159\/000457952","article-title":"Characterization of thyroid abnormalities in a Large cohort of children with down Syndrome","volume":"87","author":"Pierce","year":"2017","journal-title":"Hormone Res Paediatric"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9020221","article-title":"Metabolic diseases and down syndrome: How are they linked together","volume":"9","author":"Moreau","year":"2021","journal-title":"Biomedicines"},{"key":"B43","article-title":"Down syndrome: prenatal risk assessment and diagnosis","volume":"62","author":"Newberger","year":"2000","journal-title":"Am Fam Phys"},{"key":"B44","first-page":"1","article-title":"Fertility of men and women aged 15-44 in the united states: national survey of family growth, 2011-2015","volume":"113","author":"Martinez","year":"2018","journal-title":"Natl Health Stat Rep"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.928151\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T20:29:17Z","timestamp":1727728157000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.928151\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,5]]},"references-count":44,"alternative-id":["10.3389\/fendo.2022.928151"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2022.928151","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,5]]},"article-number":"928151"}}