{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T08:01:58Z","timestamp":1790928118924,"version":"4.1.0"},"reference-count":118,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) is one of most important gas transmitters. H<jats:sub>2<\/jats:sub>S modulates many physiological and pathological processes such as inflammation, oxidative stress and cell apoptosis that play a critical role in vascular function. Recently, solid evidence show that H<jats:sub>2<\/jats:sub>S is closely associated to various vascular diseases. However, specific function of H<jats:sub>2<\/jats:sub>S remains unclear. Therefore, in this review we systemically summarized the role of H<jats:sub>2<\/jats:sub>S in vascular diseases, including hypertension, atherosclerosis, inflammation and angiogenesis. In addition, this review also outlined a novel therapeutic perspective comprising crosstalk between H<jats:sub>2<\/jats:sub>S and smooth muscle cell function. Therefore, this review may provide new insight inH<jats:sub>2<\/jats:sub>S application clinically.<\/jats:p>","DOI":"10.3389\/fendo.2022.934231","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T05:55:46Z","timestamp":1660110946000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["Hydrogen sulfide: A new therapeutic target in vascular 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