{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T01:22:38Z","timestamp":1793496158387,"version":"4.5.0"},"reference-count":66,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T00:00:00Z","timestamp":1657584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Research data suggest that patients with Hashimoto\u2019s thyroiditis may increase the risk of cancer. However, existing research is inconsistent with this view. Therefore, to investigate the effect of Hashimoto\u2019s thyroiditis on the risk of developing cancer, we conducted this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched the PubMed and Embase databases from database establishment until March 2022. After rigorous literature screening by two authors, 23 studies that met the inclusion criteria were identified, and the required data were independently extracted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We retrieved 3591 records, and after the screening, 11 case-control studies and 12 cohort studies were included in the analysis. Data analysis suggested that patients with Hashimoto\u2019s thyroiditis had an increased risk of developing breast cancer, urogenital cancer, digestive organs cancer, hematologic cancer, and a low risk of respiratory cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This systematic review and meta-analysis showed that patients with HT may have a significantly increased risk of thyroid cancer, breast cancers, lung cancer, digestive system cancer, urogenital cancers, blood cancers, and prolactinoma people without HT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Systematic Review Registration<\/jats:title><jats:p><jats:uri>https:\/\/www.crd.york.ac.uk\/prospero\/<\/jats:uri>, identifier CRD 42022320741.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2022.937871","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T15:17:33Z","timestamp":1657639053000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":70,"title":["Cancer Risk in Hashimoto\u2019s Thyroiditis: a Systematic Review and Meta-Analysis"],"prefix":"10.3389","volume":"13","author":[{"given":"Xiaojie","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Fei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huafa","family":"Que","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.12688\/f1000research.11535.1","article-title":"Recent Advances in Understanding Autoimmune Thyroid Disease: The Tallest Tree in the Forest of Polyautoimmunity","volume":"6","author":"Bliddal","year":"2017","journal-title":"F1000Res"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102649","article-title":"Hashimoto's Thyroiditis: An Update on Pathogenic Mechanisms, Diagnostic Protocols, Therapeutic Strategies, and Potential Malignant Transformation","volume":"19","author":"Ralli","year":"2020","journal-title":"Autoimmun Rev"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/nature01322","article-title":"Inflammation and Cancer","volume":"420","author":"Coussens","year":"2002","journal-title":"Nature"},{"key":"B4","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s12199-018-0740-1","article-title":"Inflammation and Cancer","volume":"23","author":"Murata","year":"2018","journal-title":"Environ Health Prev Med"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04046-0","article-title":"Inflammation and Cancer: Back to Virchow","volume":"357","author":"Balkwill","year":"2001","journal-title":"Lancet"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.09.006","article-title":"Oxidative Stress, Inflammation, and Cancer: How are They Linked","volume":"49","author":"Reuter","year":"2010","journal-title":"Free Radic Biol Med"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.2174\/1381612827666210303143442","article-title":"Chronic Inflammation and Cancer: The Role of Endothelial Dysfunction and Vascular Inflammation","volume":"27","author":"Malhab","year":"2021","journal-title":"Curr Pharm Des"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.3755","article-title":"Association Between Thyroid Disorders and Colorectal Cancer Risk in Adult Patients in Taiwan","volume":"2","author":"L'Heureux","year":"2019","journal-title":"JAMA Netw Open"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.14639\/0392-100X-N1081","article-title":"Hashimoto's Thyroiditis in Papillary Thyroid Carcinoma: A 22-Year Study","volume":"41","author":"Hanege","year":"2021","journal-title":"Acta Otorhinol Ital"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2017.08.012","article-title":"Hashimoto's Thyroiditis - 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