{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T23:00:51Z","timestamp":1793228451454,"version":"4.5.0"},"reference-count":89,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T00:00:00Z","timestamp":1658188800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Kisspeptin and its receptor are central to reproductive health acting as key regulators of the reproductive endocrine axis in humans. Kisspeptin is most widely recognised as a regulator of gonadotrophin releasing hormone (GnRH) neuronal function. However, recent evidence has demonstrated that kisspeptin and its receptor also play a fundamental role during pregnancy in the regulation of placentation. Kisspeptin is abundantly expressed in syncytiotrophoblasts, and its receptor in both cyto- and syncytio-trophoblasts. Circulating levels of kisspeptin rise dramatically during healthy pregnancy, which have been proposed as having potential as a biomarker of placental function. Indeed, alterations in kisspeptin levels are associated with an increased risk of adverse maternal and foetal complications. This review summarises data evaluating kisspeptin\u2019s role as a putative biomarker of pregnancy complications including miscarriage, ectopic pregnancy (EP), preterm birth (PTB), foetal growth restriction (FGR), hypertensive disorders of pregnancy (HDP), pre-eclampsia (PE), gestational diabetes mellitus (GDM), and gestational trophoblastic disease (GTD).<\/jats:p>","DOI":"10.3389\/fendo.2022.942664","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T12:59:23Z","timestamp":1658235563000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":34,"title":["Kisspeptin in the Prediction of Pregnancy Complications"],"prefix":"10.3389","volume":"13","author":[{"given":"Jovanna","family":"Tsoutsouki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijal","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander N.","family":"Comninos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waljit S.","family":"Dhillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Abbara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2021.05.008","article-title":"Clinical Potential of Kisspeptin in Reproductive Health","volume":"27","author":"Abbara","year":"2021","journal-title":"Trends Mol Med"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1834399100","article-title":"Hypogonadotropic Hypogonadism Due to Loss of Function of the KiSS1-Derived Peptide Receptor GPR54","volume":"100","author":"De Roux","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035322","article-title":"The GPR54 Gene as a Regulator of Puberty","volume":"349","author":"Seminara","year":"2003","journal-title":"N Engl J Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.fertnstert.2017.10.014","article-title":"Kisspeptin as a Biomarker for Miscarriage: Let\u2019s Wait","volume":"109","author":"Savaris","year":"2018","journal-title":"Fertil Steril"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104847200","article-title":"The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-Coupled Receptor Gpr54","volume":"276","author":"Kotani","year":"2001","journal-title":"J Biol Chem"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021235","article-title":"Dramatic Elevation of Plasma Metastin Concentrations in Human Pregnancy: Metastin as a Novel Placenta-Derived Hormone in Humans","volume":"88","author":"Horikoshi","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00555.2005","article-title":"Plasma Kisspeptin is Raised in Patients With Gestational Trophoblastic Neoplasia and Falls During Treatment","volume":"291","author":"Dhillo","year":"2006","journal-title":"Am J Physiol - 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