{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:56:28Z","timestamp":1753890988530,"version":"3.41.2"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:00:00Z","timestamp":1659916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Paragangliomas (PGLs) are uncommon tumors of uncertain malignant potential. Multifocal paragangliomas are scarcely reported in the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case summary<\/jats:title><jats:p>A 25-year-old male patient was reported for the first time with multifocal para-aortic and para-vesical PGLs. The diagnosis was identified by blood catecholamine tests and enhanced CT scan and MIBG scintigraphy. A resection surgery was performed for treatment and the immunochemistry test of the tumors presented the features of PGL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A case of multifocal para-aortic and para-vesical PGLs confirmed by the catecholamine test, enhanced CT, and MIBG scintigraphy is presented. The cooperation of experienced surgeons, anesthesiologists, and endocrinologists was critical in treatment.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2022.946496","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T06:48:40Z","timestamp":1659941320000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["A rare case report of multifocal para-aortic and para-vesical paragangliomas"],"prefix":"10.3389","volume":"13","author":[{"given":"San-Chao","family":"Xiong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing-Peng","family":"Di","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng-Ni","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2022.824076","article-title":"Composite paraganglioma of the celiac trunk: A case report and a comprehensive review of the literature","volume":"9","author":"Tzikos","year":"2022","journal-title":"Front Surg"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.4158\/EP.6.3.249","article-title":"Pheochromocytoma: Clinical observations from a brooklyn tertiary hospital","volume":"6","author":"Ariton","year":"2000","journal-title":"Endocr Pract"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-022-09704-6","article-title":"Overview of the 2022 who classification of paragangliomas and pheochromocytomas","volume":"33","author":"Mete","year":"2022","journal-title":"Endocr Pathol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/SMJ.0b013e3181b2fd37","article-title":"Retroperitoneal ganglioneuroma in an adult patient: A case report and literature review of the last decade","volume":"102","author":"Papavramidis","year":"2009","journal-title":"South Med J"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32834a4ce9","article-title":"Cardiovascular manifestations of phaeochromocytoma","volume":"29","author":"Prejbisz","year":"2011","journal-title":"J Hypertens"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-16-0033","article-title":"European Society of endocrinology clinical practice guideline for long-term follow-up of patients operated on for a phaeochromocytoma or a paraganglioma","volume":"174","author":"Plouin","year":"2016","journal-title":"Eur J Endocrinol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-020-0531-0","article-title":"Recent advances in the management of pheochromocytoma and paraganglioma","volume":"43","author":"Tanabe","year":"2020","journal-title":"Hypertens Res"},{"key":"B8","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1111\/j.1440-1827.2005.01875.x","article-title":"Composite paraganglioma-ganglioneuroma of the urinary bladder","volume":"55","author":"Usuda","year":"2005","journal-title":"Pathol Int"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/5584_2016_76","article-title":"Phaeochromocytoma and paraganglioma","volume":"956","author":"Gunawardane","year":"2017","journal-title":"Adv Exp Med Biol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-3669","article-title":"Is the excess cardiovascular morbidity in pheochromocytoma related to blood pressure or to catecholamines","volume":"98","author":"Stolk","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0022-5347(17)37119-7","article-title":"Extra-adrenal pheochromocytoma","volume":"147","author":"Whalen","year":"1992","journal-title":"J Urol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1500681","article-title":"Circumstances of discovery of phaeochromocytoma: A retrospective study of 41 consecutive patients","volume":"150","author":"Baguet","year":"2004","journal-title":"Eur J Endocrinol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2009.09.022","article-title":"Clinical spectrum of pheochromocytoma","volume":"209","author":"Guerrero","year":"2009","journal-title":"J Am Coll Surg"},{"key":"B14","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s12967-022-03233-w","article-title":"Development of a radiomics model to diagnose pheochromocytoma preoperatively: A multicenter study with prospective validation","volume":"20","author":"Kong","year":"2022","journal-title":"J Transl Med"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2604","article-title":"123i-Meta-Iodobenzylguanidine scintigraphy for the detection of neuroblastoma and pheochromocytoma: Results of a meta-analysis","volume":"95","author":"Jacobson","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"B16","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1186\/s12885-022-09415-5","article-title":"Increased expression of Nrf2 and elevated glucose uptake in pheochromocytoma and paraganglioma with sdhb gene mutation","volume":"22","author":"Kamai","year":"2022","journal-title":"BMC Cancer"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djab158","article-title":"Germline Suclg2 variants in patients with pheochromocytoma and paraganglioma","volume":"114","author":"Hadrava Vanova","year":"2022","journal-title":"J Natl Cancer Inst"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1498","article-title":"Pheochromocytoma and paraganglioma: An endocrine society clinical practice guideline","volume":"99","author":"Lenders","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-021-01699-0","article-title":"An open-label, single-arm, multi-center, phase ii clinical trial of single-dose [I]Meta-iodobenzylguanidine therapy for patients with refractory pheochromocytoma and paraganglioma","volume":"36","author":"Inaki","year":"2022","journal-title":"Ann Nucl Med"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2010.07.002","article-title":"Malignant pheochromocytomas and paragangliomas - the importance of a multidisciplinary approach","volume":"37","author":"Andersen","year":"2011","journal-title":"Cancer Treat Rev"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.946496\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T06:48:43Z","timestamp":1659941323000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.946496\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,8]]},"references-count":20,"alternative-id":["10.3389\/fendo.2022.946496"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2022.946496","relation":{},"ISSN":["1664-2392"],"issn-type":[{"type":"electronic","value":"1664-2392"}],"subject":[],"published":{"date-parts":[[2022,8,8]]},"article-number":"946496"}}