{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T13:56:03Z","timestamp":1764251763482,"version":"3.41.2"},"reference-count":8,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T00:00:00Z","timestamp":1658966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Hypoglycemia is uncommon in people who are not being treated for diabetes mellitus and, when present, the differential diagnosis is broad. Artifactual hypoglycemia describes discrepancy between low capillary and normal plasma glucose levels regardless of symptoms and should be considered in patients with Raynaud\u2019s phenomenon.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>A 46-year-old female patient with a history of a sleeve gastrectomy started complaining about episodes of lipothymias preceded by sweating, nausea, and dizziness. During one of these episodes, a capillary blood glucose was obtained with a value of 24 mg\/dl. She had multiple emergency admissions with low-capillary glycemia. An exhaustive investigation for possible causes of hypoglycemia was made for 18 months. The 72h fasting test was negative for hypoglycemia. A Raynaud\u2019s phenomenon was identified during one appointment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Artifactual hypoglycemia has been described in various conditions including Raynaud\u2019s phenomenon, peripheral arterial disease, Eisenmenger syndrome, acrocyanosis, or hypothermia. With this case report, we want to reinforce the importance of being aware of this diagnosis to prevent anxiety, unnecessary treatment, and diagnostic tests.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2022.951377","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T14:18:32Z","timestamp":1659017912000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Case Report: Artifactual Hypoglycemia: A Condition That Should Not Be Forgotten"],"prefix":"10.3389","volume":"13","author":[{"given":"Sara","family":"Amaral","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Palha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"Bernardino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Silva-Nunes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2006.09.005","article-title":"Hypoglycemia","volume":"35","year":"2006","journal-title":"Endocrinol Metab Clinics North America"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-16-1062","article-title":"Pathogenesis and Management of Hypoglycemia","volume":"177","author":"Kittah","year":"2017","journal-title":"Eur Journ Endoc"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1410","article-title":"Evaluation and Management of Adult Hypoglycemic Disorders: An Endocrine Society Clinical Practice Guideline","volume":"94","author":"Cryer","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-2891","article-title":"Artifactual Hypoglycemia: An Old Term for a New Classification","volume":"37","author":"Tarasova","year":"2014","journal-title":"Diabetes Care"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13646-X","article-title":"Raynaud\u2019s Disease","volume":"361","author":"Bowling","year":"2003","journal-title":"Lancet"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez118","article-title":"Clinical Impact of Artifactual Hypoglycaemia and its Diagnosis at the Bedside","volume":"58","author":"Drenthen","year":"2019","journal-title":"Rheumatology"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7390927","article-title":"Artifactual Hypoglycaemia in Systemic Sclerosis and Raynaud\u2019s Phenomenon: A Clinical Case Report and Short Review","volume":"2016","author":"Bishay","year":"2016","journal-title":"Case Rep Endocrinol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-006389","article-title":"Prevalence, Risk Factors and Associations of Primary Raynaud\u2019s Phenomenon: Systematic Review and Meta-Analysis of Observational Studies","volume":"5","author":"Garner","year":"2015","journal-title":"BMJ Open"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.951377\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T14:18:37Z","timestamp":1659017917000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.951377\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,28]]},"references-count":8,"alternative-id":["10.3389\/fendo.2022.951377"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2022.951377","relation":{},"ISSN":["1664-2392"],"issn-type":[{"type":"electronic","value":"1664-2392"}],"subject":[],"published":{"date-parts":[[2022,7,28]]},"article-number":"951377"}}