{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T05:48:11Z","timestamp":1780465691311,"version":"3.54.1"},"reference-count":171,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T00:00:00Z","timestamp":1665532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Interleukin-18 (IL-18) is a classical member of the IL-1 superfamily of cytokines. As IL-1\u03b2, IL-18 precursor is processed by inflammasome\/caspase-1 into a mature and biologically active form. IL-18 binds to its specific receptor composed of two chains (IL-18R\u03b1 and IL-18R\u03b2) to trigger a similar intracellular signaling pathway as IL-1, ultimately leading to activation of NF-\u03baB and inflammatory processes. Independently of this IL-1-like signaling, IL-18 also specifically induces IFN-\u03b3 production, driving the Th1 immune response. In circulation, IL-18 binds to the IL-18 binding protein (IL-18BP) with high affinity, letting only a small fraction of free IL-18 able to trigger receptor-mediated signaling. In contrast to other IL-1 family members, IL-18 is produced constitutively by different cell types, suggesting implications in normal physiology. If the roles of IL-18 in inflammatory processes and infectious diseases are well described, recent experimental studies in mice have highlighted the action of IL-18 signaling in the control of energy homeostasis, pancreatic islet immunity and liver integrity during nutritional stress. At the same time, clinical observations implicate IL-18 in various metabolic diseases including obesity, type 1 and 2 diabetes and nonalcoholic fatty liver disease (NAFLD)\/nonalcoholic steatohepatitis (NASH). In the present review, we summarize and discuss both the physiological actions of IL-18 in metabolism and its potential roles in pathophysiological mechanisms leading to the most common human metabolic disorders, such as obesity, diabetes and NAFLD\/NASH.<\/jats:p>","DOI":"10.3389\/fendo.2022.971745","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T05:33:16Z","timestamp":1665552796000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":40,"title":["Interleukin-18 in metabolism: From mice physiology to human diseases"],"prefix":"10.3389","volume":"13","author":[{"given":"Emmanuel","family":"Somm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois 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