{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T10:40:12Z","timestamp":1769164812877,"version":"3.49.0"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T00:00:00Z","timestamp":1669248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Alcoholic osteonecrosis of the femoral head (ONFH) is a multifaceted illness that seriously disturbs the patients\u2019 quality of life. The role of lncRNAs in alcoholic ONFH has attracted widespread attention in recent years. This study mainly explored whether MIR31HG polymorphism affects the risk of ONFH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>There were 733 males (308 alcohol-induced ONFH patients and 425 healthy controls). Seven single nucleotide polymorphisms from MIR31HG were genotyped using the Agena MassARRAY platform. Odds ratio (OR) and 95% confidence intervals (CI) <jats:italic>via<\/jats:italic> logistic regression was applied to assess the contribution of MIR31HG variants to alcoholic ONFH susceptibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that rs10965059 was related to a lower risk of alcoholic ONFH in the overall, age, and necrotic sites analysis. Rs10965064 also showed a risk-reducing effect in the occurrence of alcoholic ONFH patients older than 40 years old.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We confirmed that MIR31HG variants have a significant correlation with the occurrence of alcoholic ONFH among the Chinese Han male population. our findings may provide new ideas for understanding the effect of MIR31HG on the prevention and diagnosis of alcoholic ONFH.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2022.976165","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T20:50:00Z","timestamp":1669323000000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["The polymorphisms of MIR31HG gene is correlated with alcohol-induced osteonecrosis of the femoral head in Chinese Han male population"],"prefix":"10.3389","volume":"13","author":[{"given":"Wei","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JianFei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOS-22-07-455","article-title":"Osteonecrosis of the femoral head: evaluation and treatment","volume":"22","author":"Zalavras","year":"2014","journal-title":"J Am Acad Orthopaedic Surgeons"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2017.05.002","article-title":"Association of gene variants of transcription factors PPAR\u03b3, RUNX2, osterix genes and COL2A1, IGFBP3 genes with the development of osteonecrosis of the femoral head in Chinese population","volume":"101","author":"Song","year":"2017","journal-title":"Bone"},{"key":"B3","doi-asserted-by":"publisher","first-page":"18926","DOI":"10.1038\/s41598-019-55188-6","article-title":"Analysis of circulating microRNAs aberrantly expressed in alcohol-induced osteonecrosis of femoral head","volume":"9","author":"Hong","year":"2019","journal-title":"Sci Rep"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-017-3740-4","article-title":"Alcohol intake and the risk of osteonecrosis of the femoral head in Japanese populations: a dose-response meta-analysis of case-control studies","volume":"36","author":"Yoon","year":"2017","journal-title":"Clin Rheumatol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-015-3061-7","article-title":"Multicentric epidemiologic study on six thousand three hundred and ninety five cases of femoral head osteonecrosis in China","volume":"40","author":"Cui","year":"2016","journal-title":"Int Orthopaedics"},{"key":"B6","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1186\/s12891-020-03553-2","article-title":"Correlation analysis between CARMEN variants and alcohol-induced osteonecrosis of the femoral head in the Chinese population","volume":"21","author":"Guo","year":"2020","journal-title":"BMC Musculoskeletal Disord"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16380","article-title":"Association between alcohol-induced osteonecrosis of femoral head and risk variants of MMPS in han population based on a case-control study","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.822","article-title":"Significant association between RETN genetic polymorphisms and alcohol-induced osteonecrosis of femoral head","volume":"7","author":"Liu","year":"2019","journal-title":"Mol Genet Genomic Med"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.08.054","article-title":"ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs","volume":"147","author":"Yang","year":"2011","journal-title":"Cell"},{"key":"B10","doi-asserted-by":"publisher","first-page":"10221","DOI":"10.1038\/ncomms10221","article-title":"H19 lncRNA alters DNA methylation genome wide by regulating s-adenosylhomocysteine hydrolase","volume":"6","author":"Zhou","year":"2015","journal-title":"Nat Commun"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2937","article-title":"LncRNA-OG promotes the osteogenic differentiation of bone marrow-derived mesenchymal stem cells under the regulation of hnRNPK","volume":"37","author":"Tang","year":"2019","journal-title":"Stem Cells (Dayton Ohio)."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27031","article-title":"LncRNA AK077216 promotes RANKL-induced osteoclastogenesis and bone resorption via NFATc1 by inhibition of NIP45","volume":"234","author":"Liu","year":"2019","journal-title":"J Cell Physiol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.29161","article-title":"The role of lncRNA RP11-154D6 in steroid-induced osteonecrosis of the femoral head through BMSC regulation","volume":"120","author":"Xiang","year":"2019","journal-title":"J Cell Biochem"},{"key":"B14","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1186\/s12943-018-0916-8","article-title":"LncRNA MIR31HG targets HIF1A and P21 to facilitate head and neck cancer cell proliferation and tumorigenesis by promoting cell-cycle progression","volume":"17","author":"Wang","year":"2018","journal-title":"Mol cancer."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-4644-z","article-title":"Decreased long noncoding RNA MIR31HG is correlated with poor prognosis and contributes to cell proliferation in gastric cancer","volume":"37","author":"Nie","year":"2016","journal-title":"Tumour Biol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2439","article-title":"Inhibition of lncRNA MIR31HG promotes osteogenic differentiation of human adipose-derived stem cells","volume":"34","author":"Jin","year":"2016","journal-title":"Stem Cells (Dayton Ohio)"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198809000-00021","article-title":"Influence of alcohol intake, cigarette smoking, and occupational status on idiopathic osteonecrosis of the femoral head","author":"Matsuo","year":"1988","journal-title":"Clin orthopaedics related Res"},{"key":"B18","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1302\/0301-620X.67B1.3155745","article-title":"Idiopathic bone necrosis of the femoral head. early diagnosis and treatment","volume":"67","author":"Ficat","year":"1985","journal-title":"J Bone Joint Surg Br volume."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh075","article-title":"Assessing the probability that a positive report is false: an approach for molecular epidemiology studies","volume":"96","author":"Wacholder","year":"2004","journal-title":"J Natl Cancer Inst"},{"key":"B20","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s40659-018-0181-8","article-title":"Knockdown of lncRNA MIR31HG inhibits cell proliferation in human HaCaT keratinocytes","volume":"51","author":"Gao","year":"2018","journal-title":"Biol Res"},{"key":"B21","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1186\/s13046-018-0853-9","article-title":"Long noncoding RNA MIR31HG inhibits hepatocellular carcinoma proliferation and metastasis by sponging microRNA-575 to modulate ST7L expression","volume":"37","author":"Yan","year":"2018","journal-title":"J Exp Clin Cancer Res: CR"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3233\/CBM-160635","article-title":"Decreased expression of LncRNA MIR31HG in human bladder cancer","volume":"17","author":"He","year":"2016","journal-title":"Cancer Biomarkers: Section Dis Markers"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S214569","article-title":"Long noncoding RNA MIR31HG abrogates the availability of tumor suppressor microRNA-361 for the growth of osteosarcoma","volume":"11","author":"Sun","year":"2019","journal-title":"Cancer Manage Res"},{"key":"B24","doi-asserted-by":"publisher","first-page":"e12388","DOI":"10.1111\/cpr.12388","article-title":"Long non-coding RNA LOC554202 modulates chordoma cell proliferation and invasion by recruiting EZH2 and regulating miR-31 expression","volume":"50","author":"Ma","year":"2017","journal-title":"Cell Proliferation"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv210","article-title":"A trans-ethnic genome-wide association study identifies gender-specific loci influencing pediatric aBMD and BMC at the distal radius","volume":"24","author":"Chesi","year":"2015","journal-title":"Hum Mol Genet"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2012.33","article-title":"An intronic variant associated with systemic lupus erythematosus changes the binding affinity of Yinyang1 to downregulate WDFY4","volume":"13","author":"Zhao","year":"2012","journal-title":"Genes Immunity"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1016\/j.jaci.2008.09.026","article-title":"A common intronic variant of CXCR3 is functionally associated with gene expression levels and the polymorphic immune cell responses to stimuli","volume":"122","author":"Choi","year":"2008","journal-title":"J Allergy Clin Immunol"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.976165\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T20:50:03Z","timestamp":1669323003000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.976165\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,24]]},"references-count":27,"alternative-id":["10.3389\/fendo.2022.976165"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2022.976165","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,24]]},"article-number":"976165"}}