{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T10:36:13Z","timestamp":1776940573036,"version":"3.51.4"},"reference-count":162,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012550","name":"Nemzeti Kutat\u00e1si, Fejleszt\u00e9si \u00e9s Innovaci\u00f3s Alap","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012550","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015269","name":"Magyarorsz\u00e1g Korm\u00e1nya","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide originally isolated as a hypothalamic peptide. It has a widespread distribution in the body and has a diverse spectrum of actions. Among other processes, PACAP has been shown to be involved in reproduction. In this review we summarize findings related to the entire spectrum of female reproduction. PACAP is a regulatory factor in gonadal hormone production, influences follicular development and plays a role in fertilization and embryonic\/placental development. Furthermore, PACAP is involved in hormonal changes during and after birth and affects maternal behavior. Although most data come from cell cultures and animal experiments, increasing number of evidence suggests that similar effects of PACAP can be found in humans. Among other instances, PACAP levels show changes in the serum during pregnancy and birth. PACAP is also present in the human follicular and amniotic fluids and in the milk. Levels of PACAP in follicular fluid correlate with the number of retrieved oocytes in hyperstimulated women. Human milk contains very high levels of PACAP compared to plasma levels, with colostrum showing the highest concentration, remaining steady thereafter for the first 7 months of lactation. All these data imply that PACAP has important functions in reproduction both under physiological and pathological conditions.<\/jats:p>","DOI":"10.3389\/fendo.2022.982551","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T01:09:24Z","timestamp":1663636164000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Female reproductive functions of the neuropeptide PACAP"],"prefix":"10.3389","volume":"13","author":[{"given":"Miklos","family":"Koppan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsuzsanna","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inez","family":"Bosnyak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dora","family":"Reglodi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291x(89)91757-9","article-title":"Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells","volume":"164","author":"Miyata","year":"1989","journal-title":"Biochem Biophys Res Commun"},{"key":"B2","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1124\/pr.109.001370","article-title":"Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery","volume":"61","author":"Vaudry","year":"2009","journal-title":"Pharmacol Rev"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10020406","article-title":"Signal transduction by VIP and PACAP receptors","volume":"10","author":"Langer","year":"2022","journal-title":"Biomedicines"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-021-01821-x","article-title":"PAC1 receptor internalization and endosomal MEK\/ERK activation is essential for PACAP-mediated neuronal excitability","volume":"71","author":"May","year":"2021","journal-title":"J Mol Neurosci"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-020-01711-8","article-title":"The G protein-coupled receptor PAC1 regulates transactivation of the receptor tyrosine kinase HER3","volume":"71","author":"Moody","year":"2021","journal-title":"J Mol Neurosci"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2012.02.001","article-title":"Receptor-independent cellular uptake of pituitary adenylate cyclase-activating polypeptide","volume":"1823","author":"Doan","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-022-02016-8","article-title":"GPCR intracellular loop regulation of beta-arrestin-mediated endosomal signaling dynamics","volume":"72","author":"Li","year":"2022","journal-title":"J Mol Neurosci"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2007.06.029","article-title":"Localization, characterization and function of pituitary adenylate cyclase-activating polypeptide during brain development","volume":"28","author":"Watanabe","year":"2007","journal-title":"Peptides"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2018.03.010","article-title":"Protective effects of pituitary adenylate cyclase activating polypeptide against neurotoxic agents","volume":"66","author":"Reglodi","year":"2018","journal-title":"Neurotoxicology"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11080994","article-title":"Multimodal role of PACAP in glioblastoma","volume":"11","author":"D\u2019Amico","year":"2021","journal-title":"Brain Sci"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-020-01687-5","article-title":"ClC-2-like chloride current alterations in a cell model of spinal and bulbar muscular atrophy, a polyglutamine disease","volume":"71","author":"Martinez-Rojas","year":"2021","journal-title":"J Mol Neurosci"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-022-01968-1","article-title":"PACAP and VIP mitigate rotenone-induced inflammation in BV-2 microglial cells","author":"Broome","year":"2022","journal-title":"J Mol Neurosci"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-021-01946-z","article-title":"Activation of lateral parabrachial nucleus (LPBn) PACAP-expressing projection neurons to the bed nucleus of the stria terminalis (BNST) enhances anxiety-like behavior","volume":"72","author":"Boucher","year":"2022","journal-title":"J Mol Neurosci"},{"key":"B14","doi-asserted-by":"publisher","first-page":"e12801","DOI":"10.1111\/gbb.12801","article-title":"PACAP-expressing neurons in the lateral habenula diminish negative emotional valence","volume":"21","author":"Levinstein","year":"2022","journal-title":"Genes Brain Behav"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052728","article-title":"Adaptive changes in the central control of energy homeostasis occur in response to variations in energy status","volume":"22","author":"Gastelum","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00320.2021","article-title":"Pituitary adenylate cyclase-activating polypeptide receptor activation in the hypothalamus recruits unique signaling pathways involved in energy homeostasis","volume":"322","author":"Maunze","year":"2022","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-014-0361-0","article-title":"Characterization of the thermoregulatory response to pituitary adenylate cyclase-activating polypeptide in rodents","volume":"54","author":"Banki","year":"2014","journal-title":"J Mol Neurosci"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00524","article-title":"Pituitary adenylate cyclase-activating polypeptide modulates hippocampal synaptic transmission and plasticity: new therapeutic suggestions for fragile X syndrome","volume":"13","author":"Ciranna","year":"2019","journal-title":"Front Cell Neurosci"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00377","article-title":"Protective effects of PACAP in peripheral organs","volume":"11","author":"Toth","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23094953","article-title":"Effects of pituitary adenylate cyclase activating polypeptide on cell death","volume":"23","author":"Horvath","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-018-1127-x","article-title":"PACAP-induced PAC1 receptor internalization and recruitment of endosomal signaling regulate cardiac neuron excitability","volume":"68","author":"Parsons","year":"2019","journal-title":"J Mol Neurosci"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00315.2020","article-title":"Attenuation of relaxing response induced by pituitary adenylate cyclase-activating polypeptide in bronchial smooth muscle of experimental asthma","volume":"319","author":"Chiba","year":"2020","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168682","article-title":"Pituitary adenylate cyclase-activating polypeptide (PACAP) in physiological and pathological processes within the gastrointestinal tract: a review","volume":"22","author":"Karpiesiuk","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1530\/REP-17-0470","article-title":"Disturbed spermatogenic signaling in pituitary adenylate cyclase activating polypeptide-deficient mice","volume":"155","author":"Reglodi","year":"2018","journal-title":"Reproduction"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13212","article-title":"Phenotypic characterization of testicular immune cells expressing immune checkpoint molecules in wild-type and pituitary adenylate cyclase-activating polypeptide-deficient mice","volume":"83","author":"Meggyes","year":"2020","journal-title":"Am J Reprod Immunol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2019.113297","article-title":"Pituitary adenylate cyclase-activating peptide (PACAP) and its receptors in mus musculus testis","volume":"286","author":"Prisco","year":"2020","journal-title":"Gen Comp Endocrinol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-012-9806-5","article-title":"Effects of pituitary adenylate cyclase activating polypeptide on human sperm motility","volume":"48","author":"Brubel","year":"2012","journal-title":"J Mol Neurosci"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod47.5.800","article-title":"A novel hypothalamic peptide, pituitary adenylate cyclase activating peptide, modulates sertoli cell function in vitro","volume":"47","author":"Heindel","year":"1992","journal-title":"Biol Reprod"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod63.5.1482","article-title":"Evidence that pituitary adenylate cyclase-activating polypeptide is a potent regulator of fetal rat testicular steroidogenesis","volume":"63","author":"El-Gehani","year":"2000","journal-title":"Biol Reprod"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.2220\/biomedres.29.321","article-title":"Suppressive action of pituitary adenylate cyclase activating polypeptide (PACAP) on proliferation of immature mouse leydig cell line TM3 cells","volume":"29","author":"Matsumoto","year":"2008","journal-title":"BioMed Res"},{"key":"B31","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1038\/s42003-021-02476-5","article-title":"Estrogen mediates sex differences in preoptic neuropeptide and pituitary hormone production in medaka","volume":"4","author":"Yamashita","year":"2021","journal-title":"Commun Biol"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.4081\/ejh.2022.3398","article-title":"Seasonal changes in the expression of PACAP, VPAC1, VPAC2, PAC1 and testicular activity in the testis of the muskrat (Ondatra zibethicus)","volume":"66","author":"Tang","year":"2022","journal-title":"Eur J Histochem"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1007\/BF03346621","article-title":"Alterations of pituitary adenylate cyclase-activating polypeptide-like immunoreactivity in the human plasma during pregnancy and after birth","volume":"33","author":"Reglodi","year":"2010","journal-title":"J Endocrinol Invest"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.142R001","article-title":"Pituitary adenylate cyclase-activating peptide-38 (PACAP)-38 is released into hypophysial portal blood in the normal male and female rat","volume":"142","author":"Dow","year":"1994","journal-title":"J Endocrinol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00869-r","article-title":"Concentrations of pituitary adenylate cyclase activating polypeptide (PACAP) in human brain nuclei","volume":"699","author":"Palkovits","year":"1995","journal-title":"Brain Res"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.1129","article-title":"Pituitary adenylate cyclase-activating polypeptide and its receptors in amphibians","volume":"54","author":"Yon","year":"2001","journal-title":"Microsc. Res Tech."},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.02.028","article-title":"Distribution and functional characterization of pituitary adenylate cyclase\u2013activating polypeptide receptors in the brain of non-human primates","volume":"160","author":"Jolivel","year":"2009","journal-title":"Neuroscience"},{"key":"B38","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-35135-3_15","article-title":"The role of PACAP in the regulation of body temperature","volume-title":"Pituitary adenylate cyclase activating polypeptide - PACAP","author":"Garami","year":"2016"},{"key":"B39","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1080\/23328940.2021.1993734","article-title":"Genetic identification of preoptic neurons that regulate body temperature in mice","volume":"9","author":"Machado","year":"2022","journal-title":"Temp. (Austin)"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00824-a","article-title":"Dipsogenic effect of pituitary adenylate cyclase activating polypeptide (PACAP38) injected into the lateral hypothalamus","volume":"696","author":"Puig de Parada","year":"1995","journal-title":"Brain Res"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2006.12.012","article-title":"Changes of PACAP levels in the brain show gender differences following short-term water and food deprivation","volume":"152","author":"Kiss","year":"2007","journal-title":"Gen Comp Endocrinol"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12010013","article-title":"The PACAP\/PAC1 receptor system and feeding","volume":"12","author":"Sureshkumar","year":"2021","journal-title":"Brain Sci"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2022.105300","article-title":"Arcuate nucleus of the hypothalamus contributes to the hypophagic effect and plasma metabolic changes induced by vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide","volume":"155","author":"Martins","year":"2022","journal-title":"Neurochem Int"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.877647","article-title":"The PACAP paradox: dynamic and surprisingly pleiotropic actions in the central regulation of energy homeostasis","volume":"13","author":"Le","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.01281","article-title":"Pituitary adenylate cyclase-activating peptide (PACAP)-glutamate co-transmission drives circadian phase-advancing responses to intrinsically photosensitive retinal ganglion cell projections by suprachiasmatic nucleus","volume":"13","author":"Lindberg","year":"2019","journal-title":"Front Neurosci"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1159\/000126475","article-title":"Pituitary adenylate cyclase-activating polypeptide stimulates arginine vasopressin release in conscious rats","volume":"57","author":"Murase","year":"1993","journal-title":"Neuroendocrinology"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1995.269.1.H135","article-title":"Central cardiovascular effects induced by intracisternal PACAP in dogs","volume":"269","author":"Seki","year":"1995","journal-title":"Am J Physiol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1159\/000054416","article-title":"Effects of centrally administered pituitary adenylate cyclase-activating polypeptide on c-fos gene expression and heteronuclear RNA for vasopressin in rat paraventricular and supraoptic nuclei","volume":"69","author":"Nomura","year":"1999","journal-title":"Neuroendocrinology"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1159\/000127113","article-title":"Evidence for the presence of receptors for pituitary adenylate cyclase-activating polypeptide in the neurohypophysis that are positively coupled to cyclic AMP formation and neurohypophyseal hormone secretion","volume":"64","author":"Lutz-Bucher","year":"1996","journal-title":"Neuroendocrinology"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2007.05.011","article-title":"What is the role of PACAP in gonadotrope function","volume":"28","author":"Counis","year":"2007","journal-title":"Peptides"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00088","article-title":"Current state of understanding of the role of PACAP in the hypothalamo-hypophyseal gonadotropin functions of mammals","volume":"11","author":"Koves","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.105.041624","article-title":"Pituitary adenylate cyclase activating polypeptide messenger RNA in the paraventricular nucleus and anterior pituitary during the rat estrous cycle","volume":"73","author":"Moore","year":"2005","journal-title":"Biol Reprod"},{"key":"B53","first-page":"60(suppl. 1):17","article-title":"Evidence for a steroid modulated expression of pituitary adenylate cyclase activating polypeptide (PACAP) in the anterior pituitary of rats","author":"Wuttke","year":"1994","journal-title":"Neuroendocrinology"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/s0196-9781(98)00049-7","article-title":"PACAP colocalizes with luteinizing and follicle-stimulating hormone immunoreactivities in the anterior lobe of the pituitary gland","volume":"19","author":"Koves","year":"1998","journal-title":"Peptides"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2007.12.009","article-title":"PACAP is transiently expressed in anterior pituitary gland of rats: In situ hybridization and cell immunoblot assay studies","volume":"29","author":"Heinzlmann","year":"2008","journal-title":"Peptides"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1996.tb17535.x","article-title":"New aspects of the neuroendocrine role of PACAP","volume":"805","author":"Koves","year":"1996","journal-title":"Ann N Y Acad Sci"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/s0196-9781(00)00214-x","article-title":"PACAP38 and PACAP27 administered intracerebroventricularly have an opposite effect on LH secretion","volume":"21","author":"Kantor","year":"2000","journal-title":"Peptides"},{"key":"B58","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1556\/019.70.2019.08","article-title":"Intranasal application of PACAP and \u03b2-cyclodextrin before the \u201ccritical period of proestrous stage\u201d can block ovulation","volume":"70","author":"Heinzlmann","year":"2019","journal-title":"Biol Futur"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1210\/endo.137.8.8754770","article-title":"Pituitary adenylate cyclase-activating polypeptide acts within the medial basal hypothalamus to inhibit prolactin and luteinizing hormone secretion","volume":"137","author":"Anderson","year":"1996","journal-title":"Endocrinology"},{"key":"B60","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1677\/joe.0.1340033","article-title":"Effects of a novel hypothalamic peptide, pituitary adenylate cyclase-activating polypeptide, on pituitary hormone release in rats","volume":"134","author":"Hart","year":"1992","journal-title":"J Endocrinol"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2004.04.021","article-title":"Effect of PACAP on LH release studied by cell immunoblot assay depends on the gender, on the time of day and in female rats on the day of the estrous cycle","volume":"123","author":"Szabo","year":"2004","journal-title":"Regul Pept"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1095\/biolreprod.112.105601","article-title":"Possible role of PACAP and its PAC1 receptor in the differential regulation of pituitary LHbeta- and FSHbeta-subunit gene expression by pulsatile GnRH stimulation","volume":"88","author":"Kanasaki","year":"2013","journal-title":"Biol Reprod"},{"key":"B63","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-35135-3_22","article-title":"Role of PACAP and its PACAP type I receptor in the central control of reproductive hormones","volume-title":"Pituitary adenylate cyclase activating polypeptide - PACAP","author":"Kanasaki","year":"2016"},{"key":"B64","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/s0167-0115(02)00185-4","article-title":"Neonatal PACAP administration in rats delays puberty through the influence of the LHRH neuronal system","volume":"109","author":"Szabo","year":"2002","journal-title":"Regul Pept"},{"key":"B65","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/s0169-328x(00)00116-9","article-title":"Central administration of an antisense oligodeoxynucleotide against type I pituitary adenylate cyclase-activating polypeptide receptor suppresses synthetic activities of LHRH-LH axis during the pubertal process","volume":"80","author":"Choi","year":"2000","journal-title":"Brain Res Mol Brain Res"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/iox030","article-title":"Interaction between kisspeptin and adenylate cyclase-activating polypeptide 1 on the expression of pituitary gonadotropin subunits: a study using mouse pituitary lbetaT2 cells","volume":"96","author":"Mijiddorj","year":"2017","journal-title":"Biol Reprod"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-018-1759-1","article-title":"Role of kisspeptin and Kiss1R in the regulation of prolactin gene expression in rat somatolactotroph GH3 cells","volume":"63","author":"Hara","year":"2019","journal-title":"Endocrine"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2018.10.006","article-title":"Effect of pituitary adenylate cyclase-activating polypeptide (PACAP) in the regulation of hypothalamic kisspeptin expression","volume":"270","author":"Tumurbaatar","year":"2019","journal-title":"Gen Comp Endocrinol"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb07004.x","article-title":"PAC1 null females display decreased fertility","volume":"921","author":"Jamen","year":"2000","journal-title":"Ann N Y Acad Sci"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/s0167-0115(02)00169-6","article-title":"Defects in reproductive functions in PACAP-deficient female mice","volume":"109","author":"Shintani","year":"2002","journal-title":"Regul Pept"},{"key":"B71","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1196\/annals.1317.038","article-title":"New insights into the central PACAPergic system from the phenotypes in PACAP- and PACAP receptor-knockout mice","volume":"1070","author":"Hashimoto","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008596","article-title":"Increased stathmin1 expression in the dentate gyrus of mice causes abnormal axonal arborizations","volume":"5","author":"Yamada","year":"2010","journal-title":"PloS One"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-012-9762-0","article-title":"PACAP is an endogenous protective factor - insights from PACAP-deficient mice","volume":"48","author":"Reglodi","year":"2012","journal-title":"J Mol Neurosci"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-014-0264-0","article-title":"Comparative protein composition of the brains of PACAP-deficient mice using mass spectrometry-based proteomic analysis","volume":"54","author":"Maasz","year":"2014","journal-title":"J Mol Neurosci"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1002\/path.5100","article-title":"Accelerated pre-senile systemic amyloidosis in PACAP knockout mice - a protective role of PACAP in age-related degenerative processes","volume":"245","author":"Reglodi","year":"2018","journal-title":"J Pathol"},{"key":"B76","doi-asserted-by":"publisher","first-page":"e0211433","DOI":"10.1371\/journal.pone.0211433","article-title":"VPAC1 receptors play a dominant role in PACAP-induced vasorelaxation in female mice","volume":"14","author":"Ivic","year":"2019","journal-title":"PloS One"},{"key":"B77","article-title":"Stereology of gonadotropin-releasing hormone (GnRH) and kisspeptin (KP) neurons in PACAP gene deficient female mice. Poster presented at the Akira Arimura Memorial VIP\/PACAP and Related Peptides Symposium: 30 Years After PACAP Discovery","author":"Vertes","year":"2019"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2007.09.003","article-title":"Pituitary adenylate cyclase-activating polypeptide (PACAP) is important for embryo implantation in mice","volume":"280","author":"Isaac","year":"2008","journal-title":"Mol Cell Endocrinol"},{"key":"B79","doi-asserted-by":"publisher","first-page":"e13035","DOI":"10.1111\/aji.13035","article-title":"Comparative analysis of decidual and peripheral immune cells and immune-checkpoint molecules during pregnancy in wild-type and PACAP-deficient mice","volume":"80","author":"Lajko","year":"2018","journal-title":"Am J Reprod Immunol"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.35960","article-title":"PACAP neurons in the ventral premammillary nucleus regulate reproductive function in the female mouse","volume":"7","author":"Ross","year":"2018","journal-title":"Elife"},{"key":"B81","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1159\/000052973","article-title":"Influence of melatonin on basal and gonadotropin-stimulated progesterone and estradiol secretion of cultured human granulosa cells and in the superfused granulosa cell system","volume":"52","author":"Bodis","year":"2001","journal-title":"Gynecol. Obstet. Invest"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1159\/000052952","article-title":"Modulatory effect of acetylcholine on gonadotropin-stimulated human granulosa cell steroid secretion","volume":"52","author":"Kornya","year":"2001","journal-title":"Gynecol. Obstet. Invest"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1080\/gye.16.4.259.264","article-title":"The effect of catecholamines, acetylcholine and histamine on progesterone release by human granulosa cells in a granulosa cell superfusion system","volume":"16","author":"Bodis","year":"2002","journal-title":"Gynecol. Endocrinol"},{"key":"B84","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1210\/rp.57.1.195","article-title":"Novel signaling pathways that control ovarian follicular development, ovulation, and luteinization","volume":"57","author":"Richards","year":"2002","journal-title":"Recent Prog Horm Res"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:24:2:155","article-title":"Serotonin may alter the pattern of gonadotropin-induced progesterone release of human granulosa cells in superfusion system","volume":"24","author":"Koppan","year":"2004","journal-title":"Endocrine"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1210\/endo.140.2.6485","article-title":"Gonadotropin stimulation of pituitary adenylate cyclase-activating polypeptide (PACAP) messenger ribonucleic acid in the rat ovary and the role of PACAP as a follicle survival factor","volume":"140","author":"Lee","year":"1999","journal-title":"Endocrinology"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1210\/endo.137.11.8895347","article-title":"Transient periovulatory expression of pituitary adenylate cyclase activating peptide in rat ovarian cells","volume":"137","author":"Gras","year":"1996","journal-title":"Endocrinology"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1210\/endo.142.9.8384","article-title":"Stage-dependent regulation of ovarian pituitary adenylate cyclase-activating polypeptide mRNA levels by GnRH in cultured rat granulosa cells","volume":"142","author":"Park","year":"2001","journal-title":"Endocrinology"},{"key":"B89","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.regpep.2004.12.021","article-title":"Role of pituitary adenylate cyclase-activating peptide (PACAP) in the cyclic recruitment of immature follicles in the rat ovary","volume":"128","author":"Gras","year":"2005","journal-title":"Regul Pept"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1016\/s0196-9781(97)00142-3","article-title":"Rat corpus luteum expresses both PACAP and PACAP type IA receptor mRNAs","volume":"18","author":"Kotani","year":"1997","journal-title":"Peptides"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1242\/dev.122.1.215","article-title":"Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates adenylate cyclase and promotes proliferation of mouse primordial germ cells","volume":"122","author":"Pesce","year":"1996","journal-title":"Development"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1677\/joe.1.06470","article-title":"Characterization and expression of different pituitary adenylate cyclase-activating polypeptide\/vasoactive intestinal polypeptide receptors in rat ovarian follicles","volume":"191","author":"Vaccari","year":"2006","journal-title":"J Endocrinol"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1210\/endo.135.1.8013355","article-title":"Pituitary adenylate cyclase-activating polypeptide stimulates steroidogenesis and adenosine 3\u2019,5\u2019-monophosphate accumulation in cultured rat granulosa cells","volume":"135","author":"Zhong","year":"1994","journal-title":"Endocrinology"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1016\/s0015-0282(97)00370-1","article-title":"Control of human luteal steroidogenesis: role of growth hormone-releasing hormone, vasoactive intestinal peptide, and pituitary adenylate cyclase-activating peptide","volume":"68","author":"Apa","year":"1997","journal-title":"Fertil. Steril."},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod66.3.830","article-title":"Pituitary adenylate cyclase-activating polypeptide modulates plasminogen activator expression in rat granulosa cell","volume":"66","author":"Apa","year":"2002","journal-title":"Biol Reprod"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1530\/REP-06-0188","article-title":"Gonadotropin-dependent regulation of bovine pituitary adenylate cyclase-activating polypeptide in ovarian follicles prior to ovulation","volume":"133","author":"Sayasith","year":"2007","journal-title":"Reproduction"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2012.00155","article-title":"Role of PACAP in female fertility and reproduction at gonadal level \u2013 recent advances","volume":"3","author":"Reglodi","year":"2012","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B98","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-35135-3_24","article-title":"PACAP in the reproductive system","volume-title":"Pituitary adenylate cyclase activating polypeptide - PACAP","author":"Canipari","year":"2016"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deab287","article-title":"Selective loss of kisspeptin signaling in oocytes causes progressive premature ovulatory failure","volume":"37","author":"Ruohonen","year":"2022","journal-title":"Hum Reprod"},{"key":"B100","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/0167-0115(95)00156-5","article-title":"Pituitary adenylate cyclase activating polypeptide (PACAP): occurrence and vasodilatory effect in the human uteroplacental unit","volume":"61","author":"Steenstrup","year":"1996","journal-title":"Regul Pept"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-010-9374-5","article-title":"Changes in the expression of pituitary adenylate cyclase-activating polypeptide in the human placenta during pregnancy and its effects on the survival of JAR choriocarcinoma cells","volume":"42","author":"Brubel","year":"2010","journal-title":"J Mol Neurosci"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1210\/endo.141.3.7346","article-title":"Pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP-receptor type 1 expression in rat and human placenta","volume":"141","author":"Scaldaferri","year":"2000","journal-title":"Endocrinology"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23105467","article-title":"Investigation of the role of pituitary adenylate cyclase-activating peptide (PACAP) and its type 1 (PAC1) receptor in uterine contractility during endometritis in pigs","volume":"23","author":"Jana","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2019.05.003","article-title":"Endometritis affects chemical coding of the dorsal root ganglia neurons supplying uterus in the sexually mature gilts","volume":"124","author":"Bulc","year":"2019","journal-title":"Res Vet Sci"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2005.08.005","article-title":"Expression of pituitary adenylate cyclase activating peptide in the uterine cervix, lumbosacral dorsal root ganglia and spinal cord of rats during pregnancy","volume":"27","author":"Papka","year":"2006","journal-title":"Peptides"},{"key":"B106","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1002\/mrd.10221","article-title":"Expression patterns of pituitary adenylate cyclase activating polypeptide and its type I receptor mRNAs in the rat placenta","volume":"64","author":"Koh","year":"2003","journal-title":"Mol Reprod Dev"},{"key":"B107","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4142\/jvs.2005.6.1.1","article-title":"Expression of pituitary adenylate cyclase activating polypeptide and its type I receptor mRNAs in human placenta","volume":"6","author":"Koh","year":"2005","journal-title":"J Vet Sci"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1177\/1933719116630421","article-title":"Expression and regulation of pituitary adenylate cyclase-activating polypeptide in rat placental cells","volume":"23","author":"Oride","year":"2016","journal-title":"Reprod Sci"},{"key":"B109","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/s1532-0456(01)00177-6","article-title":"Temporal relationships among uterine pituitary adenylate cyclase-activating polypeptide, decidual prolactin-related protein and progesterone receptor mRNAs expressions during decidualization and gestation in rats","volume":"129","author":"Spencer","year":"2001","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1016\/0303-7207(94)90143-0","article-title":"PACAP-38 positively regulates glycoprotein hormone \u03b1-gene expression in placental cells","volume":"99","author":"Desai","year":"1994","journal-title":"Mol Cell Endocrinol"},{"key":"B111","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.repbio.2020.01.005","article-title":"Possible effects of pituitary adenylate cyclase activating polypeptide (PACAP) on early embryo implantation marker HB-EGF in mouse","volume":"20","author":"Somoskoi","year":"2020","journal-title":"Reprod Biol"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-014-0337-0","article-title":"Investigation of the possible functions of PACAP in human trophoblast cells","volume":"54","author":"Horvath","year":"2014","journal-title":"J Mol Neurosci"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2008.03630.x","article-title":"Effects of pituitary adenylate cyclase activating polypeptide on the survival and signal transduction pathways in human choriocarcinoma cells","volume":"1163","author":"Boronkai","year":"2009","journal-title":"Ann N Y Acad Sci"},{"key":"B114","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/978-3-319-35135-3_23","article-title":"Occurrence and functions of PACAP in the placenta","volume-title":"Pituitary adenylate cyclase activating polypeptide - PACAP","author":"Horvath","year":"2016"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199507310-00006","article-title":"Effects of intravenously infused pituitary adenylate cyclase-activating polypeptide on arginine vasopressin and oxytocin secretion in man","volume":"6","author":"Chiodera","year":"1995","journal-title":"Neuroreport"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1159\/000127124","article-title":"Effects of intravenously infused pituitary adenylate cyclase-activating polypeptide on adenohypophyseal hormone secretion in normal men","volume":"64","author":"Chiodera","year":"1996","journal-title":"Neuroendocrinology"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1530\/JME-12-0156","article-title":"Therapeutic potential of VIP vs PACAP in diabetes","volume":"49","author":"Sanlioglu","year":"2012","journal-title":"J Mol Endocrinol"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23094788","article-title":"Exploring the pro-phagocytic and anti-inflammatory functions of PACAP and VIP in microglia: implications for multiple sclerosis","volume":"23","author":"Jansen","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.00221","article-title":"Protective effects of pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal peptide against cognitive decline in neurodegenerative diseases","volume":"14","author":"Soles-Tarres","year":"2020","journal-title":"Front Cell Neurosci"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.585082","article-title":"Intranasal administration of PACAP is an efficient delivery route to reduce infarct volume and promote functional recovery after transient and permanent middle cerebral artery occlusion","volume":"11","author":"Cherait","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-021-02381-2","article-title":"Pituitary adenylate cyclase-activating polypeptide protects against cognitive impairment caused by chronic cerebral hypoperfusion","volume":"58","author":"Guo","year":"2021","journal-title":"Mol Neurobiol"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12034","article-title":"PACAP suppresses dry eye signs by stimulating tear secretion","volume":"7","author":"Nakamachi","year":"2016","journal-title":"Nat Commun"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168825","article-title":"Retinoprotective effects of PACAP eye drops in microbead-induced glaucoma model in rats","volume":"22","author":"Szabo","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23020664","article-title":"Potential therapeutic role of pituitary adenylate cyclase-activating polypeptide for dry eye disease","volume":"23","author":"Hirabayashi","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.770980","article-title":"Evaluation of serum levels of transient receptor potential cation channel subfamily V member 1, vasoactive intestinal polypeptide, and pituitary adenylate cyclase-activating polypeptide in chronic and episodic migraine: the possible role in migraine transformation","volume":"12","author":"Togha","year":"2021","journal-title":"Front Neurol"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000717","article-title":"Calcitonin gene-related peptide and pituitary adenylate cyclase-activating polypeptide in migraine treatment","volume":"29","author":"Dominguez-Moreno","year":"2022","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"B127","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-35135-3_48","article-title":"PACAP as a potential biomarker: Alterations of PACAP levels in human physiological and pathological conditions","volume-title":"Pituitary adenylate cyclase activating polypeptide - PACAP","author":"Reglodi","year":"2016"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2006.12.010","article-title":"The effect of intravenous PACAP38 on cerebral hemodynamics in healthy volunteers","volume":"140","author":"Birk","year":"2007","journal-title":"Regul Pept"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2007.05.002","article-title":"Intravenous infusion of pituitary adenylate cyclase-activating polypeptide (PACAP) in a patient with multiple myeloma and myeloma kidney: A case study","volume":"28","author":"Li","year":"2007","journal-title":"Peptides"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-017-1025-7","article-title":"Examination of pituitary adenylate cyclase-activating polypeptide (PACAP) as a potential biomarker in heart failure patients","volume":"68","author":"Sarszegi","year":"2019","journal-title":"J Mol Neurosci"},{"key":"B131","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.peptides.2014.07.001","article-title":"Changes of PACAP level in cerebrospinal fluid and plasma of patients with severe traumatic brain injury","volume":"60","author":"Bukovics","year":"2014","journal-title":"Peptides"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1002\/jms.1884","article-title":"Investigation of pituitary adenylate cyclase activating polypeptide in human gynecological and other biological fluids by using MALDI TOF mass spectrometry","volume":"46","author":"Brubel","year":"2011","journal-title":"J Mass Spectrom."},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-012-9743-3","article-title":"Correlation between oocyte number and follicular fluid concentration of pituitary adenylate cyclase-activating polypeptide (PACAP) in women after superovulation treatment","volume":"48","author":"Koppan","year":"2012","journal-title":"J Mol Neurosci"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-08-0911","article-title":"Presence of pituitary adenylate cyclase activating polypeptide-38 in human plasma and milk","volume":"160","author":"Borzsei","year":"2009","journal-title":"Eur J Endocrinol"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-012-9779-4","article-title":"Changes in PACAP immunoreactivity in human milk and presence of PAC1 receptor in mammary gland during lactation","volume":"48","author":"Csanaky","year":"2012","journal-title":"J Mol Neurosci"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2019.04.009","article-title":"Decreased synovial fluid pituitary adenylate cyclase-activating polypeptide (PACAP) levels may reflect disease severity in post-traumatic knee osteoarthritis after anterior cruciate ligament injury","volume":"116","author":"Sun","year":"2019","journal-title":"Peptides"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.689939","article-title":"Correlation of decreased serum pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal peptide levels with non-motor symptoms in patients with parkinson\u2019s disease","volume":"13","author":"Hu","year":"2021","journal-title":"Front Aging Neurosci"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2021.170645","article-title":"Changes of pituitary adenylate cyclase activating polypeptide (PACAP) level in polytrauma patients in the early post-traumatic period","volume":"146","author":"Tamas","year":"2021","journal-title":"Peptides"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23105521","article-title":"Expression of oxidative stress and inflammation-related genes in nasal mucosa and nasal polyps from patients with chronic rhinosinusitis","volume":"23","author":"Mihalj","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B140","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1007\/s11357-022-00530-6","article-title":"Examination of pituitary adenylate cyclase-activating polypeptide in parkinson\u2019s disease focusing on correlations with motor symptoms","volume":"44","author":"Pham","year":"2022","journal-title":"Geroscience"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23073715","article-title":"PACAP-38 and PAC1 receptor alterations in plasma and cardiac tissue samples of heart failure patients","volume":"23","author":"Szabo","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B142","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/s10194-022-01435-7","article-title":"CGRP and PACAP-38 play an important role in diagnosing pediatric migraine","volume":"23","author":"Liu","year":"2022","journal-title":"J Headache Pain"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.5COVA1121-626R","article-title":"VIP Plasma levels associate with survival in severe COVID-19 patients, correlating with protective effects in SARS-CoV-2-infected cells","volume":"111","author":"Temerozo","year":"2022","journal-title":"J Leukoc Biol"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1530\/REP-07-0051","article-title":"Expression localisation and functional activity of pituitary adenylate cyclase-activating polypeptide, vasoactive intestinal polypeptide and their receptors in mouse ovary","volume":"134","author":"Barberi","year":"2007","journal-title":"Reproduction"},{"key":"B145","doi-asserted-by":"crossref","first-page":"CD002811","DOI":"10.1002\/14651858.CD002811.pub3","article-title":"Coasting (withholding gonadotrophins) for preventing ovarian hyperstimulation syndrome","volume-title":"Cochrane database of systematic reviews","author":"D\u2019Angelo","year":"2011"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1016\/s0015-0282(16)55188-7","article-title":"Ovarian hyperstimulation syndrome in novel reproductive technologies: prevention and treatment","volume":"58","author":"Navot","year":"1992","journal-title":"Fertil. Steril."},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1080\/14647270601021743","article-title":"Estimating the risks of ovarian hyperstimulation syndrome (OHSS): implications for egg donation for research","volume":"10","author":"Jayaprakasan","year":"2007","journal-title":"Hum Fertil. (Camb)"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.07.1292","article-title":"Incidence and prediction of ovarian hyperstimulation syndrome in women undergoing gonadotropin-releasing hormone antagonist in vitro fertilization cycles","volume":"85","author":"Papanikolaou","year":"2006","journal-title":"Fertil. Steril."},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211290","article-title":"Amniotic fluid: Not just fetal urine anymore","volume":"25","author":"Underwood","year":"2005","journal-title":"J Perinatol."},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1016\/j.repbio.2020.07.013","article-title":"Investigation of pituitary adenylate cyclase activating polypeptide (PACAP) in human amniotic fluid samples","volume":"20","author":"Toth","year":"2020","journal-title":"Reprod Biol"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M700090-MCP200","article-title":"Proteomics analysis of human amniotic fluid","volume":"6","author":"Cho","year":"2007","journal-title":"Mol Cell Proteomics"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12094","article-title":"Role of pituitary adenylate cyclase-activating polypeptide in modulating hypothalamic-pituitary system","volume":"17","author":"Oride","year":"2018","journal-title":"Reprod Med Biol"},{"key":"B153","article-title":"PACAP induces prolactin and growth hormone release in lactating rats separated from their pups","volume":"40","author":"Nagy","year":"1993","journal-title":"Endocr. J"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1538\/expanim.58.489","article-title":"The different effects of i.c.v. injection of pituitary adenylate cyclase activating polypeptide (PACAP) on prolactin secretion in adult male and lactating rats","volume":"58","author":"Tohei","year":"2009","journal-title":"Exp Anim"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2003.01075.x","article-title":"Impaired somatodendritic responses to pituitary adenylate cyclase-activating polypeptide (PACAP) of supraoptic neurones in PACAP type I -receptor deficient mice","volume":"15","author":"Jamen","year":"2003","journal-title":"J Neuroendocrinol."},{"key":"B156","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-35135-3_49","article-title":"Examination of PACAP during lactation","volume-title":"Pituitary adenylate cyclase activating polypeptide - PACAP","author":"Tamas","year":"2016"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2010.12.012","article-title":"Presence of pituitary adenylate cyclase-activating polypeptide (PACAP) in the plasma and milk of ruminant animals","volume":"172","author":"Czegledi","year":"2011","journal-title":"Gen Comp Endocrinol"},{"key":"B158","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1556\/APhysiol.100.2013.1.2","article-title":"Examination of PACAP38-like immunoreactivity in different milk and infant formula samples","volume":"100","author":"Csanaky","year":"2013","journal-title":"Acta Physiol Hung"},{"key":"B159","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1556\/2060.2020.00006","article-title":"Pituitary adenylate cyclase activating polypeptide concentrations in the sheep mammary gland, milk, and in the lamb blood plasma after suckling","volume":"107","author":"Pohoczky","year":"2020","journal-title":"Physiol Int"},{"key":"B160","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1007\/s12031-013-0193-3","article-title":"Influence of terminal differentiation and PACAP on the cytokine, chemokine, and growth factor secretion of mammary epithelial cells","volume":"52","author":"Csanaky","year":"2014","journal-title":"J Mol Neurosci"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-019-05307-5","article-title":"The role of kisspeptin levels in polycystic ovary syndrome: a systematic review and meta-analysis","volume":"300","author":"de Assis Rodrigues","year":"2019","journal-title":"Arch Gynecol. Obstet."},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1159\/000515660","article-title":"Kisspeptin levels in girls with precocious puberty: A systematic review and meta- analysis","volume":"93","author":"Cintra","year":"2020","journal-title":"Horm Res Paediatr"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.982551\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T01:09:48Z","timestamp":1663636188000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.982551\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,20]]},"references-count":162,"alternative-id":["10.3389\/fendo.2022.982551"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2022.982551","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.742354470.793598395","asserted-by":"object"}]},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,20]]},"article-number":"982551"}}