{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:38:01Z","timestamp":1783478281944,"version":"3.55.0"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Very little is known about the epidemiology of adrenal crises (AC) and adrenal insufficiency (AI) in adolescents and young adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data on all admissions to Australian hospitals between 2000\/1 to 2019\/20 for a principal diagnosis of AI (including AC) in 10-24 year olds were extracted from a national repository. Age and sex-specific rates and age-adjusted rates were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>Over the study, there were 3386 admissions for a principal diagnosis of AI; 24.0% (n=812) were for an AC and 50\u00b77% (n=1718) were for secondary AI. Age-adjusted AI admissions increased from 31\u00b770\/million in 2000\/1 to 54\u00b768\/million in 2019\/20 (p&amp;lt;0\u00b70001). Age-adjusted AC admissions also increased, most notably in the second decade (from 5\u00b780\/million in 2010\/11 to 15\u00b775\/million in 2019\/20) (p&amp;lt;0\u00b700001). Average AI and AC admission rates were comparable between the sexes, but rates increased significantly in females, especially in those aged 20 to 24 years, whose AC rate in 2019\/20 (39\u00b765\/million) was significantly higher than the corresponding rate in 2000\/1 (3\u00b715\/million) (p&amp;lt;0\u00b700001). Average age-adjusted SAI admission rates were higher in males (23\u00b792\/million) than females (15\u00b747\/million) (p&amp;lt;0\u00b700001). However, SAI admission rates increased only among females (from 11\u00b781\/million to 22\u00b712\/million in 2019\/20), with an increase in 20-24 year old females in the second decade from 5\u00b707\/million in 2010 to 20\u00b742\/million (p&amp;lt;0\u00b700001). Age adjusted admissions for congenital adrenal hyperplasia, primary AI (PAI) and drug-induced AI did not change significantly over the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>AC\/AI admissions increased over the first two decades of this century in the emerging adult population, particularly among females who also experienced a marked increase in AC admission rates, most evident in the second decade. Although uncertain, possible explanations include: dose of glucocorticoid replacement; non-adherence to therapy; psychosocial factors; and difficulty in transition to adult services. Admissions for SAI also increased, while rates of PAI and CAH remained constant.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2022.986342","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T04:36:50Z","timestamp":1663648610000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Trends in hospital admissions for adrenal insufficiency in adolescents and young adults in the 21st century"],"prefix":"10.3389","volume":"13","author":[{"given":"Georgina L.","family":"Chrisp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Quartararo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Torpy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Falhammar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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