{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T21:11:04Z","timestamp":1774473064986,"version":"3.50.1"},"reference-count":60,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:00:00Z","timestamp":1684886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018859","name":"Tamkeen","doi-asserted-by":"publisher","award":["G1206"],"award-info":[{"award-number":["G1206"]}],"id":[{"id":"10.13039\/501100018859","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Asthma and polycystic ovarian syndrome (PCOS) are linked in several possible ways. To date, there has been no study evaluating whether pediatric asthma is an independent risk factor for adult PCOS. Our study aimed to examine the association between pediatric asthma (diagnosed at 0-19 years) and adult PCOS (diagnosed at \u226520 years). We further assessed whether the aforementioned association differed in two phenotypes of adult PCOS which were diagnosed at 20-25 years (young adult PCOS), and at &amp;gt;25 years (older adult PCOS). We also evaluated whether the age of asthma diagnosis (0-10 vs 11-19 years) modified the association between pediatric asthma and adult PCOS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>This is a retrospective cross-sectional analysis using the United Arab Emirates Healthy Future Study (UAEHFS) collected from February 2016 to April 2022 involving 1334 Emirati females aged 18-49 years. We fitted a Poisson regression model to estimate the risk ratio (RR) and its 95% confidence interval (95% CI) to assess the association between pediatric asthma and adult PCOS adjusting for age, urbanicity at birth, and parental smoking at birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After adjusting for confounding factors and comparing to non-asthmatic counterparts, we found that females with pediatric asthma had a statistically significant association with adult PCOS diagnosed at \u226520 years (RR=1.56, 95% CI: 1.02-2.41), with a stronger magnitude of the association found in the older adult PCOS phenotype diagnosed at &amp;gt;25 years (RR=2.06, 95% CI: 1.16-3.65). Further, we also found females reported thinner childhood body size had a two-fold to three-fold increased risk of adult PCOS diagnosed at \u226520 years in main analysis and stratified analyses by age of asthma and PCOS diagnoses (RR=2.06, 95% CI: 1.08-3.93 in main analysis; RR=2.74, 95% CI: 1.22-6.15 among those diagnosed with PCOS &amp;gt; 25 years; and RR=3.50, 95% CI: 1.38-8.43 among those diagnosed with asthma at 11-19 years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pediatric asthma was found to be an independent risk factor for adult PCOS. More targeted surveillance for those at risk of adult PCOS among pediatric asthmatics may prevent or delay PCOS in this at-risk group. Future studies with robust longitudinal designs aimed to elucidate the exact mechanism between pediatric asthma and PCOS are warranted.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2023.1022272","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T06:11:05Z","timestamp":1684908665000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Association between pediatric asthma and adult polycystic ovarian syndrome (PCOS): a cross-sectional analysis of the UAE healthy future Study (UAEHFS)"],"prefix":"10.3389","volume":"14","author":[{"given":"Nirmin F.","family":"Juber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdishakur","family":"Abdulle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulla","family":"AlJunaibi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulla","family":"AlNaeemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amar","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Leinberger-Jabari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayesha S.","family":"Al Dhaheri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiman","family":"AlZaabi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatima","family":"Mezhal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"Al-Maskari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatme","family":"Alanouti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Habiba","family":"Alsafar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juma","family":"Alkaabi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laila Abdel","family":"Wareth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai","family":"Aljaber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Kazim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Weitzman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Al-Houqani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Hag-Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naima","family":"Oumeziane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"El-Shahawy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Sherman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed M.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Loney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wael","family":"Almahmeed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youssef","family":"Idaghdour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raghib","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.10.041","article-title":"Distinguishing severe asthma phenotypes: role of age at onset and eosinophilic inflammation","volume":"113","author":"Miranda","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.09.017","article-title":"Time for a paradigm shift in asthma treatment: from relieving bronchospasm to controlling systemic inflammation","volume":"120","author":"Bjermer","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00256","article-title":"Asthma in children and adults-what are the differences and what can they tell us about asthma","volume":"7","author":"Trivedi","year":"2019","journal-title":"Front Pediatr"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.07.011","article-title":"Long-term studies of the natural history of asthma in childhood","volume":"126","author":"Bisgaard","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13395","article-title":"Associations between pediatric asthma and adult non-communicable diseases","volume":"32","author":"Juber","year":"2021","journal-title":"Pediatr Allergy Immunol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12958-016-0173-x","article-title":"Genetic, hormonal and metabolic aspects of PCOS: an update","volume":"14","author":"De Leo","year":"2016","journal-title":"Reprod Biol Endocrinol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2005.00623.x","article-title":"Development of polycystic ovary syndrome: involvement of genetic and environmental factors","volume":"29","author":"Franks","year":"2006","journal-title":"Int J Androl"},{"key":"B8","doi-asserted-by":"publisher","first-page":"100937","DOI":"10.1016\/j.molmet.2020.01.001","article-title":"Metabolic dysfunction in polycystic ovary syndrome: pathogenic role of androgen excess and potential therapeutic strategies","volume":"35","author":"Sanchez-Garrido","year":"2020","journal-title":"Mol Metab"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2006.0098","article-title":"Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women","volume":"16","author":"Talbott","year":"2007","journal-title":"J Womens Health"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/59380","article-title":"The pathogenesis and treatment of polycystic ovary syndrome: what\u2019s new","volume":"26","author":"Bednarska","year":"2017","journal-title":"Adv Clin Exp Med"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2016.08.025","article-title":"Coexistence of asthma and polycystic ovary syndrome: a concise review","volume":"119","author":"Zierau","year":"2016","journal-title":"Respir Med"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01334-2016","article-title":"Asthma in reproductive-aged women with polycystic ovary syndrome and association with obesity","volume":"49","author":"Htet","year":"2017","journal-title":"Eur Respir J"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-021-00662-8","article-title":"A potential link between polycystic ovary syndrome and ssthma: a meta-analysis","volume":"29","author":"Sun","year":"2022","journal-title":"Reprod Sci"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9010233","article-title":"The association between dietary intake, asthma, and PCOS in women from the Australian longitudinal study on women\u2019s health","volume":"9","author":"Grieger","year":"2020","journal-title":"J Clin Med"},{"key":"B15","doi-asserted-by":"publisher","first-page":"6959","DOI":"10.3390\/ijms24086959","article-title":"The \u201cAsthma-polycystic ovary overlap syndrome\u201d and the therapeutic role of yo-inositol","volume":"24","author":"Guarnieri","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2012.04.016","article-title":"Dysbiosis of gut microbiota (DOGMA)\u2013a novel theory for the development of polycystic ovarian syndrome","volume":"79","author":"Tremellen","year":"2012","journal-title":"Med Hypotheses"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12931-017-0511-3","article-title":"Changes in the respiratory microbiome during acute exacerbations of idiopathic pulmonary fibrosis","volume":"18","author":"Molyneaux","year":"2017","journal-title":"Respir Res"},{"key":"B18","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.trecan.2019.12.007","article-title":"The influence of lung microbiota on lung carcinogenesis, immunity, and immunotherapy","volume":"6","author":"Ram\u00edrez-Labrada","year":"2020","journal-title":"Trends Cancer"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-3886","article-title":"The potential implications of a PCOS diagnosis on a woman\u2019s long-term health using data linkage","volume":"100","author":"Hart","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"B20","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1080\/17476348.2017.1270762","article-title":"Risk factors for premenstrual asthma: a systematic review and meta-analysis","volume":"11","author":"S\u00e1nchez-Ramos","year":"2017","journal-title":"Expert Rev Respir Med"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01698","article-title":"Androgen and androgen receptors as regulators of monocyte and macrophage biology in the healthy and diseased lung","volume":"11","author":"Becerra-Diaz","year":"2020","journal-title":"Front Immunol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2021.1958310","article-title":"Polycystic ovarian syndrome and infertility: overview and insights of the putative treatments","volume":"37","author":"Coll\u00e9e","year":"2021","journal-title":"Gynecol Endocrinol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"131092","DOI":"10.1155\/2014\/131092","article-title":"Female asthma has a negative effect on fertility: what is the connection","volume":"2014","author":"Gade","year":"2014","journal-title":"Allergy"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201303-0457OC","article-title":"Body mass index is a stronger predictor than the metabolic syndrome for future asthma in women. the longitudinal CARDIA study","volume":"188","author":"Assad","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2018.11.002","article-title":"Characteristics of obesity in polycystic ovary syndrome: etiology, treatment, and genetics","volume":"92","author":"Glueck","year":"2019","journal-title":"Metab"},{"key":"B26","first-page":"37","article-title":"Obesity and polycystic ovary syndrome","volume":"40","author":"Naderpoor","year":"2014","journal-title":"Minerva Endocrinol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14421","article-title":"Obesity and polycystic ovary syndrome","volume":"95","author":"Barber","year":"2021","journal-title":"Clin Endocrinol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000446","article-title":"The asthma\u2013obesity relationship: underlying mechanisms and treatment implications","volume":"24","author":"Carpaij","year":"2018","journal-title":"Curr Opin Pulm Med"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00018-2018","article-title":"The risk of asthma is increased among women with polycystic ovary syndrome: a twin study","volume":"5","author":"Zierau","year":"2019","journal-title":"ERJ Open Res"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S398651","article-title":"Association between self-reported polycystic ovary syndrome with chronic diseases among emiratis: a cross-sectional analysis from the UAE healthy future study","volume":"15","author":"Juber","year":"2023","journal-title":"Int J Women\u2019s Health"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.936948","article-title":"Associations between asthma and polycystic ovary syndrome: current perspectives","volume":"13","author":"Xu","year":"2022","journal-title":"Front Endocrinol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12889-017-5012-2","article-title":"The UAE healthy future study: a pilot for a prospective cohort study of 20,000 united Arab Emirates nationals","volume":"18","author":"Abdulle","year":"2018","journal-title":"BMC Public Health"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-007-0301-9","article-title":"Use of anti-asthmatic medications as a proxy for prevalence of asthma in children and adolescents in Norway: a nationwide prescription database analysis","volume":"63","author":"Furu","year":"2007","journal-title":"Eur J Clin Pharmacol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31823f7135","article-title":"A 20-year follow-up of young women with polycystic ovary syndrome","volume":"119","author":"Carmina","year":"2012","journal-title":"Obstet Gynecol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2288-3-21","article-title":"Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio","volume":"3","author":"Barros","year":"2003","journal-title":"BMC Med Res Methodol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114521002361","article-title":"Sleep disturbances may influence lifestyle behaviours in women with self-reported polycystic ovary syndrome","volume":"127","author":"Bennett","year":"2022","journal-title":"Br J Nutr"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/02770903.2022.2030750","article-title":"Associations between pediatric asthma and age at menarche: evidence from the Indonesian family life survey","volume":"60","author":"Juber","year":"2022","journal-title":"J Asthma"},{"key":"B38","doi-asserted-by":"publisher","first-page":"158951","DOI":"10.1155\/2015\/158951","article-title":"Urban rural comparisons of polycystic ovary syndrome burden among adolescent girls in a hospital setting in India","volume":"2015","author":"Balaji","year":"2015","journal-title":"BioMed Res Int"},{"key":"B39","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1159\/000369168","article-title":"In utero exposure to cigarette smoking, environmental tobacco smoke and reproductive hormones in US girls approaching puberty","volume":"83","author":"Gollenberg","year":"2015","journal-title":"Horm Res Paediatr"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1378\/chest.120.3.785","article-title":"Risk factors for childhood asthma in Costa Rica","volume":"120","author":"Celed\u00f3n","year":"2001","journal-title":"Chest"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2010.2303","article-title":"Socioeconomic status and polycystic ovary syndrome","volume":"20","author":"Merkin","year":"2011","journal-title":"J Womens Health"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2431-14-275","article-title":"Effect of low birth weight on childhood asthma: a meta-analysis","volume":"14","author":"Xu","year":"2014","journal-title":"BMC Pediatr"},{"key":"B43","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1093\/hropen\/hox010","article-title":"Birthweight and PCOS: systematic review and meta-analysis","volume":"2","author":"Sadrzadeh","year":"2017","journal-title":"Hum Reprod Open"},{"key":"B44","doi-asserted-by":"publisher","first-page":"285","DOI":"10.12998\/wjcc.v3.i3.285","article-title":"Asthma and metabolic syndrome: current knowledge and future perspectives","volume":"3","author":"Serafino-Agrusa","year":"2015","journal-title":"World J Clin cases"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2012.4.3.122","article-title":"Influence of asthma epidemiology on the risk for other diseases","volume":"4","author":"Juhn","year":"2012","journal-title":"Allergy Asthma Immunol Res"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3109\/02770903.2013.879881","article-title":"Coexisting chronic conditions associated with mortality and morbidity in adult patients with asthma","volume":"51","author":"Sumino","year":"2014","journal-title":"J Asthma"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2007.12.004","article-title":"Chronic stress, salivary cortisol, and \u03b1-amylase in children with asthma and healthy children","volume":"78","author":"Wolf","year":"2008","journal-title":"Biol Psychol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116760","article-title":"Reduced sympathetic nervous activity. a potential mechanism predisposing to body weight gain","volume":"92","author":"Spraul","year":"1993","journal-title":"J Clin Investig"},{"key":"B49","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1111\/brv.12115","article-title":"Is metabolic rate a universal \u2018pacemaker\u2019for biological processes","volume":"90","author":"Glazier","year":"2015","journal-title":"Biol Rev"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00124","article-title":"Polycystic ovarian syndrome: an updated overview","volume":"7","author":"El Hayek","year":"2016","journal-title":"Front Physiol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1515\/ijamh-2018-0166","article-title":"Awareness and opinion about polycystic ovarian syndrome (PCOS) among young women: a developing country perspective","volume":"33","author":"Jena","year":"2021","journal-title":"Int J Adolesc Med Health"},{"key":"B52","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1080\/1464727002000198771","article-title":"Polycystic ovary syndrome in adolescence and early adulthood","volume":"3","author":"Michelmore","year":"2000","journal-title":"Hum Fertil"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0212","article-title":"Androgen levels in adult females: changes with age, menopause, and oophorectomy","volume":"90","author":"Davison","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"B54","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1080\/01674820902950553","article-title":"Time since menarche, weight gain and body image awareness among adolescent girls: onset of eating disorders","volume":"30","author":"Abraham","year":"2009","journal-title":"J Psychosom Obstet Gynaecol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4172\/2375-4494.1000185","article-title":"Physical activity and sedentary behaviors as risk factors of obesity among rural adolescents","volume":"3","author":"Alqahtani","year":"2015","journal-title":"J Child Adolesc Behav"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3109\/02770903.2014.930480","article-title":"Reliability in reporting asthma history and age at asthma onset","volume":"51","author":"Mirabelli","year":"2014","journal-title":"J Asthma"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007813","article-title":"Large-Scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria","volume":"14","author":"Day","year":"2018","journal-title":"PloS Genet"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1378\/chest.104.2.600","article-title":"Asthma and asthma-like symptoms in adults assessed by questionnaires: a literature review","volume":"104","author":"Toren","year":"1993","journal-title":"Chest"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.1.24","article-title":"Women with polycystic ovary syndrome gain regular menstrual cycles when ageing","volume":"15","author":"Elting","year":"2000","journal-title":"Hum Reprod"},{"key":"B60","first-page":"1","article-title":"Childhood and maternal health in the middle East and north Africa","author":"Sagynbekov","year":"2018","journal-title":"Milken Institute"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2023.1022272\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T06:11:09Z","timestamp":1684908669000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2023.1022272\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,24]]},"references-count":60,"alternative-id":["10.3389\/fendo.2023.1022272"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2023.1022272","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,24]]},"article-number":"1022272"}}