{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:13:03Z","timestamp":1787026383885,"version":"build-2736575974"},"reference-count":69,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T00:00:00Z","timestamp":1679616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32072949, 32072993"],"award-info":[{"award-number":["32072949, 32072993"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012428","name":"Central Public-interest Scientific Institution Basal Research Fund, Chinese Academy of Fishery Sciences","doi-asserted-by":"publisher","award":["20603022022018, TD202047"],"award-info":[{"award-number":["20603022022018, TD202047"]}],"id":[{"id":"10.13039\/501100012428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010203","name":"Agriculture Research System of China","doi-asserted-by":"publisher","award":["CARS-47"],"award-info":[{"award-number":["CARS-47"]}],"id":[{"id":"10.13039\/501100010203","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>\n                    LPXRFa, also known as gonadotropin-inhibitory hormone (GnIH), and kisspeptin (Kiss) are two major hypothalamic peptides that modulate the reproductive axis of vertebrates, including teleosts. However, little information is available regarding the actions of nutritional status on the regulation of these two neuroendocrine systems in fish. Herein, we assessed the effects of starvation and refeeding on the expression of\n                    <jats:italic>lpxrfa<\/jats:italic>\n                    ,\n                    <jats:italic>kiss2<\/jats:italic>\n                    and their receptors (\n                    <jats:italic>lpxrfa-r<\/jats:italic>\n                    and\n                    <jats:italic>kiss2r<\/jats:italic>\n                    respectively) at the brain-pituitary level of half-smooth tongue sole (\n                    <jats:italic>Cynoglossus semilaevis<\/jats:italic>\n                    ). Food deprivation for 4 weeks induced a rise in brain\n                    <jats:italic>lpxrfa<\/jats:italic>\n                    as well as brain and pituitary\n                    <jats:italic>lpxrfa-r<\/jats:italic>\n                    mRNA levels, and refeeding restored brain\n                    <jats:italic>lpxrfa<\/jats:italic>\n                    and\n                    <jats:italic>lpxrfa-r<\/jats:italic>\n                    expression back to normal. However, pituitary\n                    <jats:italic>lpxrfa-r<\/jats:italic>\n                    mRNA levels still remained high after 1 week of refeeding. Neither\n                    <jats:italic>lpxrfa<\/jats:italic>\n                    nor\n                    <jats:italic>kiss2<\/jats:italic>\n                    transcripts in the pituitary were altered by fasting, but their mRNA levels increased significantly after 1 week of refeeding, and declined back to the control levels after 2 weeks of refeeding. None of brain\n                    <jats:italic>kiss2<\/jats:italic>\n                    and\n                    <jats:italic>kiss2r<\/jats:italic>\n                    along with pituitary\n                    <jats:italic>kiss2r<\/jats:italic>\n                    transcripts were modified by the nutritional status. In summary, our results revealed an interaction between energy status and the elements of LPXRFa and Kiss systems in the brain-pituitary axis of half-smooth tongue sole. Food deprivation and refeeding differentially regulated the two systems, which provided additional evidence for the involvement of the LPXRFa and Kiss systems in the regulation of reproduction by energy balance in non-mammalian species.\n                  <\/jats:p>","DOI":"10.3389\/fendo.2023.1099832","type":"journal-article","created":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T01:59:16Z","timestamp":1679623156000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Food deprivation differentially modulates gene expression of LPXRFa and kisspeptin systems in the brain-pituitary axis of half-smooth tongue sole (Cynoglossus semilaevis)"],"prefix":"10.3389","volume":"14","author":[{"given":"Bin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijun","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuezhou","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,3,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3350","article-title":"A novel avian hypothalamic peptide inhibiting gonadotropin release","volume":"275","author":"Tsutsui","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"B2","doi-asserted-by":"publisher","first-page":"100955","DOI":"10.1016\/j.yfrne.2021.100955","article-title":"Advancing reproductive neuroendocrinology through research on the regulation of GnIH and on its diverse actions on reproductive physiology and behavior","volume":"64","author":"Tsutsui","year":"2022","journal-title":"Front Neuroendocrinol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"100991","DOI":"10.1016\/j.yfrne.2022.100991","article-title":"Comparative insights of the neuroanatomical distribution of the gonadotropin-inhibitory hormone (GnIH) in fish and amphibians","volume":"65","author":"Pinelli","year":"2022","journal-title":"Front Neuroendocrinol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00285","article-title":"A journey through the gonadotropin-inhibitory hormone system of fish","volume":"8","author":"Munoz-Cueto","year":"2017","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00078","article-title":"The gonadotropin-inhibitory hormone: What we know and what we still have to learn from fish","volume":"10","author":"Di Yorio","year":"2019","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.728862","article-title":"The role of GnIH in biological rhythms and social behaviors","volume":"12","author":"Teo","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B7","doi-asserted-by":"publisher","first-page":"100954","DOI":"10.1016\/j.yfrne.2021.100954","article-title":"Gonadotropin-inhibitory hormone as a regulator of social interactions in vertebrates","volume":"64","author":"Tobari","year":"2022","journal-title":"Front Neuroendocrinol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2018.03.004","article-title":"Gonadotropin-inhibitory hormone mediates behavioral stress responses","volume":"265","author":"Ubuka","year":"2018","journal-title":"Gen Comp Endocrinol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-1904","article-title":"Gonadotropin-inhibitory hormone inhibits GnRH-induced gonadotropin subunit gene transcriptions by inhibiting AC\/cAMP\/PKA-dependent ERK pathway in LbetaT2 cells","volume":"153","author":"Son","year":"2012","journal-title":"Endocrinology."},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201500055","article-title":"Inhibitory action of gonadotropin-inhibitory hormone on the signaling pathways induced by kisspeptin and vasoactive intestinal polypeptide in GnRH neuronal cell line, GT1-7","volume":"30","author":"Son","year":"2016","journal-title":"FASEB J"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0575","article-title":"Potent action of RFamide-related peptide-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion","volume":"149","author":"Clarke","year":"2008","journal-title":"Endocrinology."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0775","article-title":"Effect of RF-amide-related peptide-3 on luteinizing hormone and follicle-stimulating hormone synthesis and secretion in ovine pituitary gonadotropes","volume":"150","author":"Sari","year":"2009","journal-title":"Endocrinology."},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2010.03.029","article-title":"Activation of the chicken gonadotropin-inhibitory hormone receptor reduces gonadotropin releasing hormone receptor signaling","volume":"167","author":"Shimizu","year":"2010","journal-title":"Gen Comp Endocrinol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1210\/en.2013-2047","article-title":"LPXRFa, the piscine ortholog of GnIH, and LPXRF receptor positively regulate gonadotropin secretion in tilapia (Oreochromis niloticus)","volume":"155","author":"Biran","year":"2014","journal-title":"Endocrinology."},{"key":"B15","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.ygcen.2015.04.016","article-title":"Molecular identification of GnIH\/GnIHR signal and its reproductive function in protogynous hermaphroditic orange-spotted grouper (Epinephelus coioides)","volume":"216","author":"Wang","year":"2015","journal-title":"Gen Comp Endocrinol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/iox032","article-title":"The gonadotropin-inhibitory hormone (Lpxrfa) system's regulation of reproduction in the brain-pituitary axis of the zebrafish (Danio rerio)","volume":"96","author":"Spicer","year":"2017","journal-title":"Biol Reprod"},{"key":"B17","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.cbpa.2018.05.008","article-title":"Characterization of LPXRFa receptor in the half-smooth tongue sole (Cynoglossus semilaevis): Molecular cloning, expression profiles, and differential activation of signaling pathways by LPXRFa peptides","volume":"223","author":"Wang","year":"2018","journal-title":"Comp Biochem Physiol A Mol Integr Physiol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioab130","article-title":"Effects of LPXRFamide peptides on chub mackerel gonadotropin secretion","volume":"105","author":"Ohga","year":"2021","journal-title":"Biol Reprod"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.982246","article-title":"Signaling pathways activated by sea bass gonadotropin-inhibitory hormone peptides in COS-7 cells transfected with their cognate receptor","volume":"13","author":"Wang","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.anireprosci.2019.01.009","article-title":"In vitro effects of tongue sole LPXRFa and kisspeptin on relative abundance of pituitary hormone mRNA and inhibitory action of LPXRFa on kisspeptin activation in the PKC pathway","volume":"203","author":"Wang","year":"2019","journal-title":"Anim Reprod Sci"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2017.07.014","article-title":"Inhibitory action of tongue sole LPXRFa, the piscine ortholog of gonadotropin-inhibitory hormone, on the signaling pathway induced by tongue sole kisspeptin in COS-7 cells transfected with their cognate receptors","volume":"95","author":"Wang","year":"2017","journal-title":"Peptides."},{"key":"B22","doi-asserted-by":"publisher","first-page":"113568","DOI":"10.1016\/j.ygcen.2020.113568","article-title":"Kisspeptin and GnRH interactions in the reproductive brain of teleosts","volume":"298","author":"Somoza","year":"2020","journal-title":"Gen Comp Endocrinol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00037.2010","article-title":"Kisspeptins and reproduction: Physiological roles and regulatory mechanisms","volume":"92","author":"Pinilla","year":"2012","journal-title":"Physiol Rev"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1530\/JME-13-0224","article-title":"Molecular evolution of GPCRs: Kisspeptin\/kisspeptin receptors","volume":"52","author":"Pasquier","year":"2014","journal-title":"J Mol Endocrinol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"113973","DOI":"10.1016\/j.ygcen.2021.113973","article-title":"Conserved functions of hypothalamic kisspeptin in vertebrates","volume":"317","author":"Sivalingam","year":"2022","journal-title":"Gen Comp Endocrinol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.862614","article-title":"Overview and new insights into the diversity, evolution, role, and regulation of kisspeptins and their receptors in teleost fish","volume":"13","author":"Wang","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B27","doi-asserted-by":"publisher","first-page":"100951","DOI":"10.1016\/j.yfrne.2021.100951","article-title":"Hypothalamic kisspeptin and kisspeptin receptors: Species variation in reproduction and reproductive behaviours","volume":"64","author":"Sivalingam","year":"2022","journal-title":"Front Neuroendocrinol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1152\/physrev.00009.2019","article-title":"Origin and evolution of the neuroendocrine control of reproduction in vertebrates, with special focus on genome and gene duplications","volume":"100","author":"Dufour","year":"2020","journal-title":"Physiol Rev"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1204","article-title":"The kiss\/kissr systems are dispensable for zebrafish reproduction: Evidence from gene knockout studies","volume":"156","author":"Tang","year":"2015","journal-title":"Endocrinology."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1210\/en.2016-1540","article-title":"Genetic evidence for multifactorial control of the reproductive axis in zebrafish","volume":"158","author":"Liu","year":"2017","journal-title":"Endocrinology."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1210\/en.2017-00808","article-title":"Evolutionally conserved function of kisspeptin neuronal system is nonreproductive regulation as revealed by nonmammalian study","volume":"159","author":"Nakajo","year":"2018","journal-title":"Endocrinology."},{"key":"B32","doi-asserted-by":"publisher","first-page":"113523","DOI":"10.1016\/j.ygcen.2020.113523","article-title":"Ectopic over expression of kiss1 may compensate for the loss of kiss2","volume":"295","author":"Etzion","year":"2020","journal-title":"Gen Comp Endocrinol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.physbeh.2004.02.007","article-title":"Energy balance and reproduction","volume":"81","author":"Schneider","year":"2004","journal-title":"Physiol Behav"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2014.00036","article-title":"Central pathways integrating metabolism and reproduction in teleosts","volume":"5","author":"Shahjahan","year":"2014","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B35","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.brainres.2005.05.035","article-title":"Gonadotropin-inhibiting hormone stimulates feeding behavior in chicks","volume":"1050","author":"Tachibana","year":"2005","journal-title":"Brain Res"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2012.11.026","article-title":"Distribution and sequence of gonadotropin-inhibitory hormone and its potential role as a molecular link between feeding and reproductive systems in the pekin duck (Anas platyrhynchos domestica)","volume":"184","author":"Fraley","year":"2013","journal-title":"Gen Comp Endocrinol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1159\/000332822","article-title":"Gonadotropin-inhibitory hormone is a hypothalamic peptide that provides a molecular switch between reproduction and feeding","volume":"95","author":"Clarke","year":"2012","journal-title":"Neuroendocrinology."},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2006.09.009","article-title":"Rat RFamide-related peptide-3 stimulates GH secretion, inhibits LH secretion, and has variable effects on sex behavior in the adult male rat","volume":"51","author":"Johnson","year":"2007","journal-title":"Horm Behav"},{"key":"B39","doi-asserted-by":"publisher","first-page":"36057","DOI":"10.1038\/srep36057","article-title":"Kisspeptin and RFRP-3 differentially regulate food intake and metabolic neuropeptides in the female desert jerboa","volume":"6","author":"Talbi","year":"2016","journal-title":"Sci Rep"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2018.12.003","article-title":"Centrally administered kisspeptin suppresses feeding via nesfatin-1 and oxytocin in male rats","volume":"112","author":"Saito","year":"2019","journal-title":"Peptides."},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e32834558df","article-title":"Centrally injected kisspeptin reduces food intake by increasing meal intervals in mice","volume":"22","author":"Stengel","year":"2011","journal-title":"Neuroreport."},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-019-05950-7","article-title":"Intraperitoneal treatment of kisspeptin suppresses appetite and energy expenditure and alters gastrointestinal hormones in mice","volume":"65","author":"Dong","year":"2020","journal-title":"Dig Dis Sci"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2012.03.009","article-title":"Hypothalamic gonadotropin-inhibitory hormone precursor mRNA is increased during depressed food intake in heat-exposed chicks","volume":"162","author":"Chowdhury","year":"2012","journal-title":"Comp Biochem Physiol Part A: Mol Integr Physiol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"113438","DOI":"10.1016\/j.ygcen.2020.113438","article-title":"Food access modifies GnIH, but not CRH, cell number in the hypothalamus in a female songbird","volume":"292","author":"Wilsterman","year":"2020","journal-title":"Gen Comp Endocrinol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ygcen.2015.03.010","article-title":"Food, stress, and circulating testosterone: Cue integration by the testes, not the brain, in male zebra finches (Taeniopygia guttata)","volume":"215","author":"Lynn","year":"2015","journal-title":"Gen Comp Endocrinol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.domaniend.2006.04.008","article-title":"Increased food intake stimulates GnRH-I, glycoprotein hormone alpha-subunit and follistatin mRNAs, and ovarian follicular numbers in laying broiler breeder hens","volume":"33","author":"Ciccone","year":"2007","journal-title":"Domest Anim Endocrinol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"113207","DOI":"10.1016\/j.ygcen.2019.06.011","article-title":"Effects of fasting on the central expression of appetite-regulating and reproductive hormones in wild-type and casper zebrafish (Danio rerio)","volume":"282","author":"London","year":"2019","journal-title":"Gen Comp Endocrinol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0500","article-title":"Regulation of hypothalamic expression of KiSS-1 and GPR54 genes by metabolic factors: Analyses using mouse models and a cell line","volume":"148","author":"Luque","year":"2007","journal-title":"Endocrinology."},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-0337","article-title":"Changes in hypothalamic KiSS-1 system and restoration of pubertal activation of the reproductive axis by kisspeptin in undernutrition","volume":"146","author":"Castellano","year":"2005","journal-title":"Endocrinology."},{"key":"B50","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.mce.2011.03.004","article-title":"Gene structure analysis of kisspeptin-2 (Kiss2) in the Senegalese sole (Solea senegalensis): characterization of two splice variants of Kiss2, and novel evidence for metabolic regulation of kisspeptin signaling in non-mammalian species","volume":"339","author":"Mechaly","year":"2011","journal-title":"Mol Cell Endocrinol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00604","article-title":"Evidence of alternative splicing as a regulatory mechanism for Kissr2 in pejerrey fish","volume":"9","author":"Mechaly","year":"2018","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B52","doi-asserted-by":"publisher","first-page":"100953","DOI":"10.1016\/j.yfrne.2021.100953","article-title":"Regulation of stress response on the hypothalamic-pituitary-gonadal axis via gonadotropin-inhibitory hormone","volume":"64","author":"Son","year":"2022","journal-title":"Front Neuroendocrinol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.ygcen.2017.04.006","article-title":"Molecular characterization of Kiss2 receptor and in vitro effects of Kiss2 on reproduction-related gene expression in the hypothalamus of half-smooth tongue sole (Cynoglossus semilaevis)","volume":"249","author":"Wang","year":"2017","journal-title":"Gen Comp Endocrinol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.cbpa.2017.08.003","article-title":"Molecular characterization of kiss2 and differential regulation of reproduction-related genes by sex steroids in the hypothalamus of half-smooth tongue sole (Cynoglossus semilaevis)","volume":"213","author":"Wang","year":"2017","journal-title":"Comp Biochem Physiol A Mol Integr Physiol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.cbpb.2017.11.016","article-title":"Molecular characterization and expression profiles of LPXRFa at the brain-pituitary-gonad axis of half-smooth tongue sole (Cynoglossus semilaevis) during ovarian maturation","volume":"216","author":"Wang","year":"2018","journal-title":"Comp Biochem Physiol B Biochem Mol Biol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.ygcen.2018.11.011","article-title":"Recent studies of LPXRFa receptor signaling in fish and other vertebrates","volume":"277","author":"Wang","year":"2019","journal-title":"Gen Comp Endocrinol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"100544","DOI":"10.1016\/j.aqrep.2020.100544","article-title":"Characterization of a novel spexin gene (spx2) in the half-smooth tongue sole and regulation of its expression by nutritional status","volume":"18","author":"Wang","year":"2020","journal-title":"Aquac Rep"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2011.00053","article-title":"Beyond leptin: Emerging candidates for the integration of metabolic and reproductive function during negative energy balance","volume":"2","author":"True","year":"2011","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-14-0688","article-title":"The involvement of gonadotropin inhibitory hormone and kisspeptin in the metabolic regulation of reproduction","volume":"225","author":"Wahab","year":"2015","journal-title":"J Endocrinol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.781543","article-title":"Gonadotropin inhibitory hormone and its receptor: Potential key to the integration and coordination of metabolic status and reproduction","volume":"12","author":"Bedecarrats","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B61","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.ygcen.2016.01.004","article-title":"Stimulation of food intake after central administration of gonadotropin-inhibitory hormone is similar in genetically selected low and high body weight lines of chickens","volume":"232","author":"McConn","year":"2016","journal-title":"Gen Comp Endocrinol"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/icx097","article-title":"RFamide-related peptide-3 and the trade-off between reproductive and ingestive behavior","volume":"57","author":"Schneider","year":"2017","journal-title":"Integr Comp Biol"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00662","article-title":"How to contribute to the progress of neuroendocrinology: Discovery of GnIH and progress of GnIH research","volume":"9","author":"Tsutsui","year":"2018","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B64","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.cbpa.2016.05.005","article-title":"Is the kisspeptin system involved in responses to food restriction in order to preserve reproduction in pubertal male sea bass (Dicentrarchus labrax)","volume":"199","author":"Escobar","year":"2016","journal-title":"Comp Biochem Physiol A Mol Integr Physiol"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1269852","article-title":"Decrease in hypothalamic Kiss1 and Kiss1r expression: a potential mechanism for fasting-induced suppression of the HPG axis in the adult male rhesus monkey (Macaca mulatta)","volume":"43","author":"Wahab","year":"2011","journal-title":"Horm Metab Res"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1530\/REP-13-0426","article-title":"Food restriction during lactation suppresses Kiss1 mRNA expression and kisspeptin-stimulated LH release in rats","volume":"147","author":"Ladyman","year":"2014","journal-title":"Reproduction."},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2015.06.016","article-title":"The effect of short fasting on the hypothalamic neuronal system of kisspeptin in peripubertal female lambs","volume":"159","author":"Polkowska","year":"2015","journal-title":"Anim Reprod Sci"},{"key":"B68","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.npep.2015.06.005","article-title":"Fasting induced kisspeptin signaling suppression is regulated by glutamate mediated cues in adult male rhesus macaque (Macaca mulatta)","volume":"52","author":"Shamas","year":"2015","journal-title":"Neuropeptides."},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00123","article-title":"Metabolic impact on the hypothalamic kisspeptin-Kiss1r signaling pathway","volume":"9","author":"Wahab","year":"2018","journal-title":"Front Endocrinol (Lausanne)"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2023.1099832\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T01:59:20Z","timestamp":1679623160000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2023.1099832\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,24]]},"references-count":69,"alternative-id":["10.3389\/fendo.2023.1099832"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2023.1099832","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,24]]},"article-number":"1099832"}}