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The pathogenesis underlying NVG makes it refractory to routine management for other types of glaucoma in clinical practice. The combination of panretinal photocoagulation (PRP), anti-vascular endothelial growth factor (VEGF) injections, anti-glaucoma drugs, surgical intervention as well as blood glucose control is needed. Early diagnosis and aggressive treatment in time are crucial in halting the neovascularization process and preserving vision. This review provides an overview of NVG secondary to diabetic retinopathy (DR), including the epidemiology, pathogenesis and management, so as to provide a better understanding as well as potential therapeutic strategies for future treatment.<\/jats:p>","DOI":"10.3389\/fendo.2023.1102361","type":"journal-article","created":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T12:17:01Z","timestamp":1674476221000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":68,"title":["The mechanism and therapeutic strategies for neovascular glaucoma secondary to diabetic retinopathy"],"prefix":"10.3389","volume":"14","author":[{"given":"Yizhen","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2007.06.001","article-title":"Neovascular glaucoma","volume":"26","author":"Hayreh","year":"2007","journal-title":"Prog Retin Eye Res"},{"key":"B2","article-title":"Neovascular glaucoma, in glaucoma","volume-title":"Glaucoma Medical Diagnosis and Therapy","author":"Palma","year":"2015"},{"key":"B3","volume-title":"CHAPTER 16 - secondary angle-closure glaucoma, in becker-shaffer's diagnosis and therapy of the glaucomas","author":"Stamper","year":"2009"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-11950","article-title":"The prevalence and types of glaucoma in an urban Indian population: the Singapore Indian eye study","volume":"54","author":"Narayanaswamy","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.126.8.1091","article-title":"Prevalence and causes of low vision and blindness in an urban malay population: the Singapore Malay eye study","volume":"126","author":"Wong","year":"2008","journal-title":"Arch Ophthalmol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s12886-016-0190-8","article-title":"Neovascular glaucoma: a retrospective review from a tertiary center in China","volume":"16","author":"Liao","year":"2016","journal-title":"BMC Ophthalmol"},{"key":"B7","first-page":"58","article-title":"[Neovascular glaucoma\u2013retrospective study]","volume":"49","author":"Mocanu","year":"2005","journal-title":"Oftalmologia"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-0342","article-title":"Ocular associations of diabetes other than diabetic retinopathy","volume":"31","author":"Jeganathan","year":"2008","journal-title":"Diabetes Care"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(84)34293-2","article-title":"Neovascular glaucoma. 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