{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:56:43Z","timestamp":1792112203820,"version":"4.4.0"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The study aimed to determine the effect of the scanning area used for high-speed ultra-widefield swept-source optical coherence tomography angiography (SS-OCTA) on the detection rate of diabetic retinopathy (DR) lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective, observational study involved diabetic patients between October 2021 and April 2022. The participants underwent a comprehensive ophthalmic examination and high-speed ultra-widefield SS-OCTA using a 24\u00a0mm \u00d7 20\u00a0mm scanning protocol. A central area denoted as \u201c12 mm \u00d7 12 mm-central\u201d was extracted from the 24\u00a0mm \u00d7 20\u00a0mm image, and the remaining area was denoted as \u201c12 mm~24mm-annulus.\u201d The rates of detection of DR lesions using the two scanning areas were recorded and compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 172 eyes (41 eyes with diabetes mellitus without DR, 40 eyes with mild to moderate non-proliferative diabetic retinopathy (NPDR), 51 eyes with severe NPDR, and 40 eyes with proliferative diabetic retinopathy (PDR) from 101 participants were included. The detection rates of microaneurysms (MAs), intraretinal microvascular abnormalities (IRMAs), and neovascularization (NV) for the 12\u00a0mm \u00d7 12\u00a0mm central and 24\u00a0mm \u00d7 20\u00a0mm images were comparable (p &amp;gt; 0.05). The detection rate of NPAs for the 24\u00a0mm \u00d7 20\u00a0mm image was 64.5%, which was significantly higher than that for the 12\u00a0mm \u00d7 12\u00a0mm central image (52.3%, p &amp;lt; 0.05). The average ischemic index (ISI) was 15.26% for the 12 mm~24mm-annulus, which was significantly higher than that for the 12\u00a0mm \u00d7 12\u00a0mm central image (5.62%). Six eyes had NV and 10 eyes had IRMAs that only existed in the 12 mm~24mm-annulus area.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The newly developed high-speed ultra-widefield SS-OCTA can capture a 24\u00a0mm \u00d7 20\u00a0mm retinal vascular image during a single scan, which improves the accuracy of detecting the degree of retinal ischemia and detection rate of NV and IRMAs.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2023.1111360","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T06:26:32Z","timestamp":1676874392000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Different scan areas affect the detection rates of diabetic retinopathy lesions by high-speed ultra-widefield swept-source optical coherence tomography 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