{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T17:45:21Z","timestamp":1782409521875,"version":"3.54.5"},"reference-count":48,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T00:00:00Z","timestamp":1681862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014137","name":"Shanghai Shenkang Hospital Development Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014137","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Idiopathic hyperaldosteronism (IHA) is one of the most common types of primary aldosteronism (PA), an important cause of hypertension. Although high dietary sodium is a major risk factor for hypertension, there is no consensus on the recommended dietary sodium intake for IHA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study investigated the effect of a low-sodium diet on hemodynamic variables and relevant disease biomarkers in IHA patients, with the aim of providing a useful reference for clinical treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty IHA patients were evenly randomized into two groups and provided, after a 7-day run-in period (100 mmol\/d sodium), either a low-sodium diet (50 mmol\/d sodium) or a normal sodium diet (100 mmol\/d sodium) for an additional 7 days. After the 14-day intervention (conducted without potassium supplementation), changes in blood pressure (BP) and serum potassium were evaluated in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After the dietary intervention, the low sodium group exhibited, compared to the normal sodium group, decreased BP (SBP: 121.8 \u00b1 12.8 <jats:italic>vs<\/jats:italic>. 129.9 \u00b1 12.1 mmHg, p &amp;lt; 0.05; DBP: 82.6 \u00b1 7.6 <jats:italic>vs<\/jats:italic>. 86.4 \u00b1 8.2 mmHg, p &amp;lt; 0.05; MAP: 95.7 \u00b1 8.8 <jats:italic>vs<\/jats:italic>. 100.9 \u00b1 8.4 mmHg, p &amp;lt; 0.05) and increased serum potassium levels (3.38 \u00b1 0.33 <jats:italic>vs<\/jats:italic>. 3.07 \u00b1 0.27 mmol\/L, p &amp;lt; 0.001). The low sodium group showed also better control of both BP and serum potassium: BP &amp;lt;140\/90 mmHg in 70.0% of total patients (76.0% <jats:italic>vs<\/jats:italic>. 64.0%, in the low and normal sodium groups, respectively; p &amp;gt; 0.05), BP &amp;lt;130\/85 mmHg in 38.0% of total patients (56.0% <jats:italic>vs<\/jats:italic>. 20.0%, p &amp;lt; 0.05), BP &amp;lt;120\/80 mmHg in 28.0% of total patients (44.0% <jats:italic>vs<\/jats:italic>. 12.0%, p &amp;lt; 0.05); serum potassium \u22653.5 mmol\/L in 22.0% of total patients (32.0% <jats:italic>vs<\/jats:italic>. 12.0% in the low and normal sodium groups, respectively; p = 0.088). There were differences between the controlled BP group (&amp;lt;120\/80 mmHg) and the non-controlled BP group (\u2265120\/80 mmHg) in gender, BP at baseline, and type of diet (low <jats:italic>vs<\/jats:italic>. normal sodium). Female gender and low-sodium diet were protective factors for BP control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A low-sodium diet is effective in lowering BP and elevating serum potassium in IHA patients. Female patients on a low-sodium diet are more likely to achieve BP control (&amp;lt;120\/80 mmHg). We advocate a dietary sodium intake of 50 mmol\/d for IHA patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical trial registration<\/jats:title><jats:p><jats:ext-link>https:\/\/clinicaltrials.gov<\/jats:ext-link>, Identifier NCT05649631.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2023.1124479","type":"journal-article","created":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T05:14:22Z","timestamp":1681881262000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Effects of a low-sodium diet in patients with idiopathic hyperaldosteronism: a randomized controlled trial"],"prefix":"10.3389","volume":"14","author":[{"given":"Lihua","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingwei","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luming","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,4,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1295438","article-title":"Prevalence of primary aldosteronism in patient's cohorts and in population-based studies\u2013a review of the current literature","volume":"44","author":"Hannemann","year":"2012","journal-title":"Horm Metab Res"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.02.052","article-title":"Primary aldosteronism in patients in China with recently detected hypertension","volume":"75","author":"Xu","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/S2213-8587(17)30319-4","article-title":"Cardiovascular events and target organ damage in primary aldosteronism compared with essential hypertension: a systematic review and meta-analysis","volume":"6","author":"Monticone","year":"2018","journal-title":"Lancet Diabetes Endocrinol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.09.057","article-title":"Primary aldosteronism: JACC state-of-the-Art review","volume":"74","author":"Rossi","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1243257","article-title":"Comorbidities in primary aldosteronism","volume":"42","author":"Quinkler","year":"2010","journal-title":"Horm Metab Res"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1246189","article-title":"Is primary aldosteronism associated with diabetes mellitus? 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