{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T17:04:51Z","timestamp":1794330291042,"version":"4.9.0"},"reference-count":64,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:00:00Z","timestamp":1692230400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Dysfunction in the hypothalamic-pituitary-adrenal axis has been associated with depressive and anxiety disorders. Little is known about the risk for these disorders among individuals with congenital adrenal hyperplasia (CAH), a form of primary adrenal insufficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We investigated the prevalence of depressive and anxiety disorders and antidepressant prescriptions in two large healthcare databases of insured children, adolescents, and young adults with CAH in the United States.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective cohort study using administrative data from October 2015 through December 2019 for individuals aged 4\u201325 years enrolled in employer-sponsored or Medicaid health plans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Adjusting for age, the prevalence of depressive disorders [adjusted prevalence ratio (aPR) = 1.7, 95% confidence interval (CI): 1.4-2.0, p&amp;lt;0.001], anxiety disorders [aPR = 1.7, 95% CI: 1.4-1.9, p&amp;lt;0.001], and filled antidepressant prescriptions [aPR = 1.7, 95% CI: 1.4-2.0, p&amp;lt;0.001] was higher among privately insured youth with CAH as compared to their non-CAH peers. Prevalence estimates were also higher among publicly insured youth with CAH for depressive disorders [aPR = 2.3, 95% CI: 1.9-2.9, p&amp;lt;0.001], anxiety disorders [aPR = 2.0, 95% CI: 1.6-2.5, p&amp;lt;0.001], and filled antidepressant prescriptions [aPR = 2.5, 95% CI: 1.9-3.1, p&amp;lt;0.001] as compared to their non-CAH peers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The elevated prevalence of depressive and anxiety disorders and antidepressant prescriptions among youth with CAH suggests that screening for symptoms of depression and anxiety among this population might be warranted.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2023.1129584","type":"journal-article","created":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T07:48:49Z","timestamp":1692344929000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Depressive and anxiety disorders and antidepressant prescriptions 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