{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:47:03Z","timestamp":1789588023299,"version":"build-2803163510"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T00:00:00Z","timestamp":1678320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The increased prevalence of non-alcoholic fatty liver disease (NAFLD) and sarcopenia among the elderly are facing a significant challenge to the world\u2019s health systems. Our study aims to identify the coexpressed genes in NAFLD and sarcopenia patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We downloaded the transcriptome data of NAFLD tissue from patients, as well as muscle tissues from sarcopenia patients, from the GEO database in order to investigate the shared transcriptional regulation mechanisms between these two diseases. Then, focusing on the genes that were frequently expressed in these diseases, together with GSVA and WGCNA, we utilized a range of analysis methods to identify the main co-expressed genes in both diseases by taking intersections. We investigated these changes after learning that they mostly affected lipid metabolism and oxidative stress injury pathways.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>By analyzing these genes and their interactions with transcription factors and proteins, we were able to identify 8 genes that share common patterns. From these 8 genes, we were possible to forecast potential future medicines. Our research raises the possibility of NAFLD and sarcopenia transcriptome regulatory pathways in aging populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>In conclusion, a complete transcription pattern mapping was carried out in order to identify the core genes, underlying biological mechanisms, and possible therapeutic targets that regulate aging in NAFLD and sarcopenia patients. It provides novel insights and proof in favor of decreasing the increased prevalence of sarcopenia in the elderly caused by NAFLD.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2023.1140804","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T05:45:50Z","timestamp":1678340750000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Exploration of the core gene signatures and mechanisms between NAFLD and sarcopenia through transcriptomic level"],"prefix":"10.3389","volume":"14","author":[{"given":"Ziying","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihui","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyan","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuping","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,3,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29466","article-title":"Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease","volume":"67","author":"Estes","year":"2018","journal-title":"Hepatology"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30349-8","article-title":"'The global, regional, and national burden of cirrhosis by cause in 195 countries and territories 1990-2017: a systematic analysis for the global burden of disease study 2017' g","volume":"5","year":"2020","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.10.025","article-title":"The global NAFLD policy review and preparedness index: Are countries ready to address this silent public health challenge","volume":"76","author":"Lazarus","year":"2022","journal-title":"J Hepatol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30251","article-title":"Global perspectives on nonalcoholic fatty liver disease and nonalcoholic steatohepatitis","volume":"69","author":"Younossi","year":"2019","journal-title":"Hepatology"},{"key":"B5","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.cmet.2019.08.018","article-title":"Fatty liver disease caused by high-Alcohol-Producing klebsiella pneumoniae","volume":"30","author":"Yuan","year":"2019","journal-title":"Cell Metab"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23169196","article-title":"mTOR: A potential new target in nonalcoholic fatty liver disease","volume":"23","author":"Feng","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31138-9","article-title":"Sarcopenia","volume":"393","author":"Cruz-Jentoft","year":"2019","journal-title":"Lancet"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-017-0277-0","article-title":"Epidemiology of sarcopenia: Determinants throughout the lifecourse","volume":"101","author":"Shaw","year":"2017","journal-title":"Calcif Tissue Int"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2017.60","article-title":"Epidemiology of sarcopenia and insight into possible therapeutic targets","volume":"13","author":"Dennison","year":"2017","journal-title":"Nat Rev Rheumatol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12613","article-title":"Sustained NFkappaB inhibition improves insulin sensitivity but is detrimental to muscle health","volume":"16","author":"Zhang","year":"2017","journal-title":"Aging Cell"},{"key":"B11","doi-asserted-by":"publisher","first-page":"116539","DOI":"10.1016\/j.bone.2022.116539","article-title":"Lipid metabolism in sarcopenia","volume":"164","author":"Al Saedi","year":"2022","journal-title":"Bone"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/cld.900","article-title":"Association of sarcopenia and NAFLD: An overview","volume":"16","author":"Li","year":"2020","journal-title":"Clin Liver Dis (Hoboken)"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12754","article-title":"Risk stratification using sarcopenia status among subjects with metabolic dysfunction-associated fatty liver disease","volume":"12","author":"Chun","year":"2021","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.702661","article-title":"Similarity and potential relation between periimplantitis and rheumatoid arthritis on transcriptomic level: Results of a bioinformatics study","volume":"12","author":"Li","year":"2021","journal-title":"Front Immunol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"853916","DOI":"10.1155\/2010\/853916","article-title":"Uncovering the complexity of transcriptomes with RNA-seq","volume":"2010","author":"Costa","year":"2010","journal-title":"J BioMed Biotechnol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-021-01185-6","article-title":"Role of transcriptome sequencing in clinical diagnosis of b-cell acute lymphoblastic leukemia","volume":"35","author":"Li","year":"2021","journal-title":"Leukemia"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-9593-6_10","article-title":"Vaccinia virus transcriptome analysis by RNA sequencing","volume":"2023","author":"Cao","year":"2019","journal-title":"Methods Mol Biol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-00787-0","article-title":"Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex","volume":"24","author":"Maynard","year":"2021","journal-title":"Nat Neurosci"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22031474","article-title":"Analysis of m6A RNA methylation-related genes in liver hepatocellular carcinoma and their correlation with survival","volume":"22","author":"Li","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.952987","article-title":"Bioinformatics and systems biology approach to identify the pathogenetic link of long COVID and myalgic Encephalomyelitis\/Chronic fatigue syndrome","volume":"13","author":"Lv","year":"2022","journal-title":"Front Immunol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1002\/jez.b.21150","article-title":"Insights from diploblasts; the evolution of mesoderm and muscle","volume":"310","author":"Burton","year":"2008","journal-title":"J Exp Zool B Mol Dev Evol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.semcdb.2018.09.003","article-title":"The contributions of mesoderm-derived cells in liver development","volume":"92","author":"Yang","year":"2019","journal-title":"Semin Cell Dev Biol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"e14607","DOI":"10.14814\/phy2.14607","article-title":"Mechanisms of muscle insulin resistance and the cross-talk with liver and adipose tissue","volume":"8","author":"da Silva Rosa","year":"2020","journal-title":"Physiol Rep"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201696150","article-title":"Endothelial cell metabolism in health and disease: impact of hypoxia","volume":"36","author":"Wong","year":"2017","journal-title":"EMBO J"},{"key":"B25","doi-asserted-by":"publisher","first-page":"105484","DOI":"10.1016\/j.phrs.2021.105484","article-title":"Epigenetics in NAFLD\/NASH: Targets and therapy","volume":"167","author":"Sodum","year":"2021","journal-title":"Pharmacol Res"},{"key":"B26","doi-asserted-by":"publisher","first-page":"101576","DOI":"10.1016\/j.arr.2022.101576","article-title":"Multi-omics research in sarcopenia: Current progress and future prospects","volume":"76","author":"Liu","year":"2022","journal-title":"Ageing Res Rev"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.10.034","article-title":"Skeletal muscle as potential central link between sarcopenia and immune senescence","volume":"49","author":"Nelke","year":"2019","journal-title":"EBioMedicine"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcli.2022.06.017","article-title":"Non-alcoholic steatohepatitis","volume":"159","author":"Romero-Gomez","year":"2022","journal-title":"Med Clin (Barc)"},{"key":"B29","doi-asserted-by":"publisher","first-page":"145796","DOI":"10.1016\/j.gene.2021.145796","article-title":"Up-down regulation of HIF-1alpha in cancer progression","volume":"798","author":"Rashid","year":"2021","journal-title":"Gene"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2020106214","article-title":"BNIP3 promotes HIF-1alpha-driven melanoma growth by curbing intracellular iron homeostasis","volume":"40","author":"Vara-Perez","year":"2021","journal-title":"EMBO J"},{"key":"B31","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1038\/s41419-019-1728-5","article-title":"Adrenomedullin alleviates the pyroptosis of leydig cells by promoting autophagy via the ROS-AMPK-mTOR axis","volume":"10","author":"Li","year":"2019","journal-title":"Cell Death Dis"},{"key":"B32","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1038\/s41419-018-0530-0","article-title":"Epithelial cell-derived cytokines CST3 and GDF15 as potential therapeutics for pulmonary fibrosis","volume":"9","author":"Kim","year":"2018","journal-title":"Cell Death Dis"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.06.007","article-title":"Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis","volume":"14","author":"Pihlajamaki","year":"2011","journal-title":"Cell Metab"},{"key":"B34","doi-asserted-by":"publisher","first-page":"101242","DOI":"10.1016\/j.isci.2020.101242","article-title":"Srsf7 establishes the juvenile transcriptome through age-dependent alternative splicing in mice","volume":"23","author":"Kadota","year":"2020","journal-title":"iScience"},{"key":"B35","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.1016\/j.cmet.2021.09.008","article-title":"DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing","volume":"33","author":"Li","year":"2021","journal-title":"Cell Metab"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay9592","article-title":"Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia","volume":"13","author":"Sartori","year":"2021","journal-title":"Sci Transl Med"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1172\/JCI139617","article-title":"Mesenchymal Bmp3b expression maintains skeletal muscle integrity and decreases in age-related sarcopenia","volume":"131","author":"Uezumi","year":"2021","journal-title":"J Clin Invest"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201211134","article-title":"The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass","volume":"203","author":"Winbanks","year":"2013","journal-title":"J Cell Biol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s13046-022-02254-z","article-title":"FTO suppresses glycolysis and growth of papillary thyroid cancer via decreasing stability of APOE mRNA in an N6-methyladenosine-dependent manner","volume":"41","author":"Huang","year":"2022","journal-title":"J Exp Clin Cancer Res"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1007\/s10038-003-0086-3","article-title":"Association of over-expressed TFDP1 with progression of hepatocellular carcinomas","volume":"48","author":"Yasui","year":"2003","journal-title":"J Hum Genet"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.742319","article-title":"An E2F5-TFDP1-BRG1 complex mediates transcriptional activation of MYCN in hepatocytes","volume":"9","author":"Fan","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1186\/s12964-019-0456-x","article-title":"Karyopherin alpha2-dependent import of E2F1 and TFDP1 maintains protumorigenic stathmin expression in liver cancer","volume":"17","author":"Drucker","year":"2019","journal-title":"Cell Commun Signal"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10081797","article-title":"Effects of resveratrol administration in liver injury prevention as induced by an obesogenic diet: Role of ruminococcaceae","volume":"10","author":"Milton-Laskibar","year":"2022","journal-title":"Biomedicines"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1080\/09637486.2022.2027889","article-title":"A short-term treatment with resveratrol improves the inflammatory conditions of middle-aged mice skeletal muscles","volume":"73","author":"Sirago","year":"2022","journal-title":"Int J Food Sci Nutr"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-021-00502-9","article-title":"Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests","volume":"18","author":"Masoodi","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.14670\/HH-11-648","article-title":"Liver gender dimorphism\u2013insights from quantitative morphology","volume":"30","author":"Marcos","year":"2015","journal-title":"Histol Histopathol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1016\/j.cell.2017.07.042","article-title":"Circadian reprogramming in the liver identifies metabolic pathways of aging","volume":"170","author":"Sato","year":"2017","journal-title":"Cell"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2023.1140804\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T05:45:55Z","timestamp":1678340755000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2023.1140804\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,9]]},"references-count":47,"alternative-id":["10.3389\/fendo.2023.1140804"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2023.1140804","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,9]]},"article-number":"1140804"}}