{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T23:48:02Z","timestamp":1783381682314,"version":"3.54.6"},"reference-count":79,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T00:00:00Z","timestamp":1681948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Vitamin D affects adipogenesis, oxidative stress, inflammation, secretion of adipocytokines, lipid metabolism and thermogenesis. Some researchers postulate that those effects could be exerted by the influence of vitamin D on chemerin levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim of the study<\/jats:title><jats:p>We aimed to investigate if there is a link between serum 25-hydroksyvitamin D [25(OH)D], chemerin and metabolic profile in overweight and obese children before and after vitamin D supplementation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>The prospective study included 65 overweight and obese children aged 9.08-17.5 years and 26 peers as a control. None of the patients in the study group had received vitamin D within the last twelve months before the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study group had lower baseline 25(OH)D (p&amp;lt;0.001) and higher chemerin (p&amp;lt;0.001), triglycerides (TG, p&amp;lt;0.001), triglycerides\/high density lipoprotein cholesterol (TG\/HDL-C, p&amp;lt;0.001), C-reactive protein (CRP, p&amp;lt;0.05), fasting insulin (p&amp;lt;0.001), Homeostasis Model Assessment - Insulin Resistance (HOMA-IR, p&amp;lt;0.001), alanine aminotransferase (ALT, p&amp;lt;0.001) and uric acid (p&amp;lt;0.001) compared to the control group. Baseline vitamin D was related to fasting insulin (R=-0.29, p=0.021), HOMA-IR (R=-0.30, p=0.016), HDL-C (R=0.29, p=0.020) and uric acid (R=-0.28, p=0.037) in the study group. Baseline chemerin was related to insulin at 30\u2019 (R=0.27, p=0.030), 60\u2019 (R=0.27, p=0.033), 90\u2019 (R=0.26, p=0.037) and 120\u2019 (R=0.26, p=0.040) during the oral glucose tolerance test (OGTT) and ALT (R=0.25, p=0.041) in the study group. Correlation between vitamin D and chemerin (R=-0.39, p=0.046) was found only in the control group. After six months of vitamin D supplementation a decrease in CRP (p&amp;lt;0.01), total cholesterol (p&amp;lt;0.05), ALT (p&amp;lt;0.01), glucose at 150\u2019 OGTT (p&amp;lt;0.05) was observed. Moreover, we noticed a tendency for negative association between 25(OH)D and chemerin levels (p=0.085). Multivariable backward linear regression models were build using baseline vitamin D, baseline chemerin and six months chemerin as the dependent variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study confirmed that vitamin D has positive effect on metabolic profile in overweight and obese children. The relationship between vitamin D and chemerin is not clear, nevertheless we have observed a tendency to decrease chemerin concentrations after improving vitamin D status, even without a significant reduction in body fat mass.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2023.1143755","type":"journal-article","created":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T21:59:40Z","timestamp":1682027980000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["The link between vitamin D, chemerin and metabolic profile in overweight and obese children - preliminary 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