{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:11:03Z","timestamp":1783440663537,"version":"3.54.6"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T00:00:00Z","timestamp":1684800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1052\/3"],"award-info":[{"award-number":["SFB 1052\/3"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010215","name":"Deutsche Diabetes Gesellschaft","doi-asserted-by":"publisher","award":["934300-002, Projektpreis der AG Diabetes und Niere 2020"],"award-info":[{"award-number":["934300-002, Projektpreis der AG Diabetes und Niere 2020"]}],"id":[{"id":"10.13039\/501100010215","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","award":["Novo Nordisk postdoctoral fellowship run in partnership with Karolinska Institutet, Stockholm, Sweden"],"award-info":[{"award-number":["Novo Nordisk postdoctoral fellowship run in partnership with Karolinska Institutet, Stockholm, Sweden"]}],"id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","award":["Karolinska Institutet Research Foundation  grant"],"award-info":[{"award-number":["Karolinska Institutet Research Foundation  grant"]}],"id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013964","name":"Stiftelsen Stig och Gunborg Westman","doi-asserted-by":"publisher","award":["Research grant 2021"],"award-info":[{"award-number":["Research grant 2021"]}],"id":[{"id":"10.13039\/501100013964","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008035","name":"Njurfonden","doi-asserted-by":"publisher","award":["Research grant 2020"],"award-info":[{"award-number":["Research grant 2020"]}],"id":[{"id":"10.13039\/501100008035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001648","name":"European Foundation for the Study of Diabetes","doi-asserted-by":"publisher","award":["EFSD Mentorship Programme supported by AstraZeneca"],"award-info":[{"award-number":["EFSD Mentorship Programme supported by AstraZeneca"]}],"id":[{"id":"10.13039\/501100001648","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013699","name":"Bundesministerium f\u00fcr Bildung, Wissenschaft und Forschung","doi-asserted-by":"publisher","award":["FKZ 01EO1501, IFB Adiposity Diseases"],"award-info":[{"award-number":["FKZ 01EO1501, IFB Adiposity Diseases"]}],"id":[{"id":"10.13039\/501100013699","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013811","name":"Medizinische Fakult\u00e4t, Universit\u00e4t Leipzig","doi-asserted-by":"publisher","award":["934100-012"],"award-info":[{"award-number":["934100-012"]}],"id":[{"id":"10.13039\/501100013811","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014913","name":"Freistaat Sachsen","doi-asserted-by":"publisher","award":["ERA PerMed (Horizon 2020), PETictCAC\" project (ERAPerMed_324)"],"award-info":[{"award-number":["ERA PerMed (Horizon 2020), PETictCAC\" project (ERAPerMed_324)"]}],"id":[{"id":"10.13039\/501100014913","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Acyl-CoA-binding protein (ACBP)\/diazepam-binding inhibitor has lately been described as an endocrine factor affecting food intake and lipid metabolism. ACBP is dysregulated in catabolic\/malnutrition states like sepsis or systemic inflammation. However, regulation of ACBP has not been investigated in conditions with impaired kidney function, so far.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design\/methods<\/jats:title><jats:p>Serum ACBP concentrations were investigated by enzyme-linked immunosorbent assay i) in a cohort of 60 individuals with kidney failure (KF) on chronic haemodialysis and compared to 60 individuals with a preserved kidney function; and ii) in a human model of acute kidney dysfunction (AKD). In addition, <jats:italic>mACBP<\/jats:italic> mRNA expression was assessed in two CKD mouse models and in two distinct groups of non-CKD mice. Further, mRNA expression of <jats:italic>mACBP<\/jats:italic> was measured <jats:italic>in vitro<\/jats:italic> in isolated, differentiated mouse adipocytes - brown and white - after exposure to the uremic agent indoxyl sulfate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median [interquartile range] serum ACBP was almost 20-fold increased in KF (514.0 [339.3] \u00b5g\/l) compared to subjects without KF (26.1 [39.1] \u00b5g\/l) (p&amp;lt;0.001). eGFR was the most important, inverse predictor of circulating ACBP in multivariate analysis (standardized \u03b2=-0.839; p&amp;lt;0.001). Furthermore, AKD increased ACBP concentrations almost 3-fold (p&amp;lt;0.001). Increased ACBP levels were not caused by augmented <jats:italic>mACBP<\/jats:italic> mRNA expression in different tissues of CKD mice <jats:italic>in vivo<\/jats:italic> or in indoxyl sulfate-treated adipocytes <jats:italic>in vitro<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Circulating ACBP inversely associates with renal function, most likely through renal retention of the cytokine. Future studies need to investigate ACBP physiology in malnutrition-related disease states, such as CKD, and to adjust for markers of renal function.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2023.1152444","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T05:13:51Z","timestamp":1684818831000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Renal function is a major predictor of circulating acyl-CoA-binding protein\/diazepam-binding inhibitor"],"prefix":"10.3389","volume":"14","author":[{"given":"Robin","family":"Sch\u00fcrfeld","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Sandner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annett","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Kl\u00f6ting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterine","family":"Baratashvili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Nowicki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Paeschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Kosacka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Kralisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anette","family":"Bachmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Frille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Dietel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens-Uwe","family":"Stolzenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Bl\u00fcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Zhi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond C.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berend","family":"Isermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Stumvoll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"T\u00f6njes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Ebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30045-3","article-title":"Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the global burden of disease study 2017","volume":"395","author":"Bikbov","year":"2020","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2020.8184","article-title":"Inflammation and oxidative stress in chronic kidney disease and dialysis patients","volume":"35","author":"Ebert","year":"2021","journal-title":"Antioxid Redox Signal"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2022.101099","article-title":"Ageing - oxidative stress, ptms and disease","volume":"86","author":"Ebert","year":"2022","journal-title":"Mol Aspects Med"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.050686","article-title":"Cardiovascular disease in chronic kidney disease: pathophysiological insights and therapeutic options","volume":"143","author":"Jankowski","year":"2021","journal-title":"Circulation"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2019.09.002","article-title":"US renal data system 2019 annual data report: epidemiology of kidney disease in the united states","volume":"75","author":"Saran","year":"2019","journal-title":"Am J Kidney Dis"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2022.02.012","article-title":"Diabetes prevalence, treatment, control, and outcomes among hemodialysis patients in the gulf cooperation council countries","volume":"7","author":"Al-Ghamdi","year":"2022","journal-title":"Kidney Int Rep"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-021-00423-5","article-title":"Lipoproteins and fatty acids in chronic kidney disease: molecular and metabolic alterations","volume":"17","author":"Noels","year":"2021","journal-title":"Nat Rev Nephrol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1016\/j.cmet.2019.10.011","article-title":"Acyl-Coa-Binding protein is a lipogenic factor that triggers food intake and obesity","volume":"30","author":"Bravo-San Pedro","year":"2019","journal-title":"Cell Metab"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)91632-6","article-title":"Diazepam binding inhibitor-like Immunoreactivity(51-70): distribution in human brain, spinal cord and peripheral tissues","volume":"479","author":"Ball","year":"1989","journal-title":"Brain Res"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.101144","article-title":"Epidermal acyl-Coa-Binding protein is indispensable for systemic energy homeostasis","volume":"44","author":"Neess","year":"2021","journal-title":"Mol Metab"},{"key":"B11","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1038\/s41419-020-2716-5","article-title":"Metabolic and psychiatric effects of acyl coenzyme a binding protein (Acbp)\/Diazepam binding inhibitor (Dbi)","volume":"11","author":"Joseph","year":"2020","journal-title":"Cell Death Dis"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13751","article-title":"High plasma concentrations of acyl-coenzyme a binding protein (Acbp) predispose to cardiovascular disease: evidence for a phylogenetically conserved proaging function of acbp","volume":"22","author":"Montegut","year":"2022","journal-title":"Aging Cell"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000560","article-title":"Increased hypothalamic levels of endozepines, endogenous ligands of benzodiazepine receptors, in a rat model of sepsis","volume":"45","author":"Clavier","year":"2016","journal-title":"Shock"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-014-0633-7","article-title":"Increased plasma levels of endozepines, endogenous ligands of benzodiazepine receptors, during systemic inflammation: a prospective observational study","volume":"18","author":"Clavier","year":"2014","journal-title":"Crit Care"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2017.01.005","article-title":"The novel Adipokine\/Hepatokine fetuin b in severe human and murine diabetic kidney disease","volume":"43","author":"Kralisch","year":"2017","journal-title":"Diabetes Metab"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-19-0017","article-title":"The brown fat-secreted adipokine neuregulin 4 is decreased in human and murine chronic kidney disease","volume":"181","author":"Kralisch","year":"2019","journal-title":"Eur J Endocrinol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann Intern Med"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.2337\/dc22-S002","article-title":"American Diabetes association professional practice c. 2. classification and diagnosis of diabetes: standards of medical care in diabetes-2022","volume":"45","author":"Draznin","year":"2022","journal-title":"Diabetes Care"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2014.03.006","article-title":"Circulating adipocyte fatty acid binding protein is increased in chronic and acute renal dysfunction","volume":"24","author":"Ebert","year":"2014","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0220","article-title":"Serum levels of the adipokine progranulin depend on renal function","volume":"36","author":"Richter","year":"2013","journal-title":"Diabetes Care"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1987.265","article-title":"Acute adaptative changes to unilateral nephrectomy in humans","volume":"32","author":"Argiles","year":"1987","journal-title":"Kidney Int"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg482","article-title":"Risks and complications in 160 living kidney donors who underwent nephroureterectomy","volume":"18","author":"Siebels","year":"2003","journal-title":"Nephrol Dial Transplant"},{"key":"B23","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1007\/BF03375463","article-title":"A calculator for homa","volume":"47","author":"Holman","year":"2004","journal-title":"Diabetologia"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006070798","article-title":"Endothelial nitric oxide synthase deficiency produces accelerated nephropathy in diabetic mice","volume":"17","author":"Zhao","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00315.2002","article-title":"Diabetic kidney disease in the Db\/Db mouse","volume":"284","author":"Sharma","year":"2003","journal-title":"Am J Physiol Renal Physiol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-20-0087","article-title":"Pro-neurotensin depends on renal function and is related to all-cause mortality in chronic kidney disease","volume":"183","author":"Tonjes","year":"2020","journal-title":"Eur J Endocrinol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.266","article-title":"Circulating progranulin but not renal progranulin expression is increased in renal dysfunction","volume":"88","author":"Ebert","year":"2015","journal-title":"Kidney Int"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfw472","article-title":"Fstl3 is increased in renal dysfunction","volume":"32","author":"Kralisch","year":"2017","journal-title":"Nephrol Dial Transplant"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.49.34795","article-title":"Beta(3)-adrenergic stimulation differentially inhibits insulin signaling and decreases insulin-induced glucose uptake in brown adipocytes","volume":"274","author":"Klein","year":"1999","journal-title":"J Biol Chem"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00090.2005","article-title":"Interleukin-6 is a negative regulator of visfatin gene expression in 3t3-L1 adipocytes","volume":"289","author":"Kralisch","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2015.1125996","article-title":"The uremic toxin indoxyl sulfate exacerbates reactive oxygen species production and inflammation in 3t3-L1 adipose cells","volume":"50","author":"Stockler-Pinto","year":"2016","journal-title":"Free Radic Res"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.133","article-title":"Indolic uremic solutes increase tissue factor production in endothelial cells by the aryl hydrocarbon receptor pathway","volume":"84","author":"Gondouin","year":"2013","journal-title":"Kidney Int"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm210","article-title":"Review on uraemic toxins iii: recommendations for handling uraemic retention solutes in vitro\u2013towards a standardized approach for research on uraemia","volume":"22","author":"Cohen","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-4349","article-title":"Circulating angiopoietin-like protein 8 is independently associated with fasting plasma glucose and type 2 diabetes mellitus","volume":"99","author":"Ebert","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.82.3.3817","article-title":"Increased plasma leptin concentration in end-stage renal disease","volume":"82","author":"Merabet","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.421","article-title":"The adipose tissue production of adiponectin is increased in end-stage renal disease","volume":"83","author":"Martinez Cantarin","year":"2013","journal-title":"Kidney Int"},{"key":"B37","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/s41419-021-03864-9","article-title":"Effects of acyl-coenzyme a binding protein (Acbp)\/Diazepam-binding inhibitor (Dbi) on body mass index","volume":"12","author":"Joseph","year":"2021","journal-title":"Cell Death Dis"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22129","article-title":"Reduced fasting plasma levels of diazepam-binding inhibitor in adolescents with anorexia nervosa","volume":"46","author":"Conti","year":"2013","journal-title":"Int J Eat Disord"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/bs.mcb.2020.12.004","article-title":"Quantification of intracellular Acbp\/Dbi levels","volume":"165","author":"Sica","year":"2021","journal-title":"Methods Cell Biol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4179(93)90104-i","article-title":"Immunomodulatory properties of diazepam-binding inhibitor: effect on human interleukin-6 secretion, lymphocyte proliferation and natural killer cell activity in vitro","volume":"25","author":"Stepien","year":"1993","journal-title":"Neuropeptides"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.67.5.637","article-title":"Diazepam-binding inhibitor-derived peptides induce intracellular calcium changes and modulate human neutrophil function","volume":"67","author":"Cosentino","year":"2000","journal-title":"J Leukoc Biol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/15548627.2022.2131241","article-title":"Cardio-, hepato- and pneumoprotective effects of autophagy checkpoint inhibition by targeting Dbi\/Acbp","author":"Motino","year":"2022","journal-title":"Autophagy"},{"key":"B43","doi-asserted-by":"publisher","first-page":"e2207344119","DOI":"10.1073\/pnas.2207344119","article-title":"Acbp\/Dbi protein neutralization confers autophagy-dependent organ protection through inhibition of cell loss, inflammation, and fibrosis","volume":"119","author":"Motino","year":"2022","journal-title":"Proc Natl Acad Sci U.S.A."}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2023.1152444\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T05:14:00Z","timestamp":1684818840000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2023.1152444\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,23]]},"references-count":43,"alternative-id":["10.3389\/fendo.2023.1152444"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2023.1152444","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,23]]},"article-number":"1152444"}}