{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T03:19:08Z","timestamp":1786591148133,"version":"build-2736575974"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T00:00:00Z","timestamp":1685491200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The <jats:italic>solute carrier family 30 A8 zinc transporter<\/jats:italic> (<jats:italic>SLC30A8<\/jats:italic>) plays a crucial role in insulin secretion. This study aimed to investigate the impact of <jats:italic>SLC30A8<\/jats:italic> gene polymorphisms on gestational diabetes mellitus (GDM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The research objective was to select 500 patients with GDM and 502 control subjects. Rs13266634 and rs2466293 were genotyped using the SNPscan\u2122 genotyping assay. Statistical tests, such as the chi-square test, t-test, logistic regression, ANOVA, and meta-analysis, were conducted to determine the differences in genotypes, alleles, and their associations with GDM risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Statistically significant differences were observed in age, pregestational BMI, SBP, DBP, and parity between individuals with GDM and healthy subjects (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). After adjusting for these factors, rs2466293 remained significantly associated with an increased risk of GDM in overall subjects (GG+AG vs. AA: OR = 1.310; 95% CI: 1.005-1.707; <jats:italic>P<\/jats:italic> = 0.046, GG vs. AA: OR = 1.523; 95% CI: 1.010-2.298; <jats:italic>P<\/jats:italic> = 0.045 and G vs. A: OR = 1.249; 95% CI: 1.029-1.516; <jats:italic>P<\/jats:italic> = 0.024). Rs13266634 was still found to be significantly associated with a decreased risk of GDM in individuals aged \u2265 30 years (TT vs. CT+CC: OR = 0.615; 95% CI: 0.392-0.966; <jats:italic>P<\/jats:italic> = 0.035, TT vs. CC: OR = 0.503; 95% CI: 0.294-0.861; <jats:italic>P<\/jats:italic> = 0.012 and T vs. C: OR =0.723; 95% CI: 0.557-0.937; <jats:italic>P<\/jats:italic> = 0.014). Additionally, the haplotype CG was found to be associated with a higher risk of GDM (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). Furthermore, pregnant women with the CC or CT genotype of rs13266634 exhibited significantly higher mean blood glucose levels than those with the TT genotype (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). Our findings were further validated by the results of a meta-analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The <jats:italic>SLC30A8<\/jats:italic> rs2466293 polymorphism was found to be associated with an increased risk of GDM, while rs13266634 was associated with a decreased risk of GDM in individuals aged \u2265 30 years. These findings provide a theoretical basis for GDM testing.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2023.1159714","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T13:41:40Z","timestamp":1685540500000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Association of solute carrier family 30 A8 zinc transporter gene variations with gestational diabetes mellitus risk in a Chinese 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