{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T04:18:34Z","timestamp":1782706714936,"version":"3.54.5"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T00:00:00Z","timestamp":1687132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Although paravertebral intramuscular fatty infiltration (known as myosteatosis) following a vertebral fracture is well-known, scarce data are available regarding interactions between muscle, bone, and other fat depots. Based on a homogeneous cohort comprising postmenopausal women with or without a history of fragility fracture, we aimed to better depict the interrelationship between myosteatosis and bone marrow adiposity (BMA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>102 postmenopausal women were included, 56 of whom had a fragility fracture. Mean proton density fat fraction (PDFF) was measured in the psoas (PDFF<jats:sub>Psoas<\/jats:sub>) and paravertebral (PDFF<jats:sub>Paravertebral<\/jats:sub>) muscles at the lumbar level, as well as in the lumbar spine and non-dominant hip using chemical shift encoding-based water-fat imaging. Visceral adipose tissue (VAT) and total body fat (TBF) were assessed using dual X-ray absorptiometry. Statistical models were adjusted for age, weight, height (all comparisons), and bone mineral density (when considering BMA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PDFF in the psoas and paravertebral muscles was higher in the fracture group compared to controls even after adjustment for age, weight, and height (PDFF<jats:sub>Psoas<\/jats:sub> = 17.1 \u00b1 6.1% versus 13.5 \u00b1 4.9%, p=0.004; PDFF<jats:sub>Paravertebral<\/jats:sub> = 34.4 \u00b1 13.6% versus 24.9 \u00b1 8.8%, p=0.002). Higher PDFF<jats:sub>Paravertebral<\/jats:sub> was associated with lower PDFF at the lumbar spine (<jats:italic>\u03b2<\/jats:italic> = -6.80 \u00b1 2.85, p=0.022) among controls but not in the fracture group. In both groups, a significant relationship between higher PDFF<jats:sub>Psoas<\/jats:sub> and higher VAT was observed (<jats:italic>\u03b2<\/jats:italic> = 20.27 \u00b1 9.62, p=0.040 in the fracture group, and <jats:italic>\u03b2<\/jats:italic> = 37.49 \u00b1 8.65, p&amp;lt;0.001 in the control group). Although solely observed among controls, a similar relationship was observed between PDFF<jats:sub>Paravertebral<\/jats:sub> and TBF (<jats:italic>\u03b2<\/jats:italic> = 6.57 \u00b1 1.80, p&amp;lt;0.001). No significant association was observed between BMA and other fat depots.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Myosteatosis is not associated with BMA among postmenopausal women with fragility fractures. Whereas myosteatosis was associated with other fat depots, BMA appears uniquely regulated.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2023.1178464","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T11:52:43Z","timestamp":1687175563000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Myosteatosis and bone marrow adiposity are not associated among postmenopausal women with fragility 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