{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T08:28:40Z","timestamp":1765268920780,"version":"3.41.2"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T00:00:00Z","timestamp":1687132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The objective of this study was to explore whether the duration of LFEP (late-follicular elevated progesterone) affected pregnancy outcomes in IVF (<jats:italic>in vitro<\/jats:italic> fertilization) patients treated with pituitary downregulation protocols.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Patients with their first IVF\/ICSI cycles between January 2016 and December 2016 were included. LFEP was set either at P &amp;gt; 1.0ng\/ml or P &amp;gt; 1.5ng\/ml. Clinical pregnancy rate was compared among three different groups (no LFEP; LFEP for 1 day; LFEP for \u2265 2 days). Then multivariate logistic regression analysis was performed to explore the influencing factors of clinical pregnancy rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This retrospective analysis involved 3,521 first IVF\/ICSI cycles with fresh embryo transfers. Clinical pregnancy rate was the lowest in patients with a LFEP duration of \u2265 2 days, irrespective of whether LFEP was defined as P &amp;gt; 1.0 ng\/ml (68.79% vs. 63.02% vs. 56.20%; <jats:italic>P<\/jats:italic> = 0.000) or as P &amp;gt; 1.5 ng\/ml (67.24% vs. 55.95% vs. 45.51%; <jats:italic>P<\/jats:italic> = 0.000). In addition, LFEP duration was significantly associated with clinical pregnancy outcomes in unadjusted logistic regression analysis. However, in multivariate regression models after adjusting confounders, adjusted OR for LFEP duration (\u2265 2 days) in the two models was 0.808 (<jats:italic>P<\/jats:italic> = 0.064; LFEP as P &amp;gt; 1.0 ng\/ml) and 0.720 (<jats:italic>P<\/jats:italic> = 0.098; LFEP as P &amp;gt; 1.5 ng\/ml), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LFEP adversely affects clinical pregnancy outcomes. However, the duration of LFEP seems to have no influence on the clinical pregnancy rate in pituitary downregulation treatment cycles.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2023.1186146","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T06:39:00Z","timestamp":1687156740000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Duration of late-follicular elevated progesterone and in vitro fertilization outcomes in pituitary down-regulation treatment cycles"],"prefix":"10.3389","volume":"14","author":[{"given":"Jiaxin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofei","family":"Ge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqin","family":"Bu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,6,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-015-0487-1","article-title":"Ratio of progesterone-to-number of follicles as a prognostic tool for in vitro fertilization cycles","volume":"32","author":"Roque","year":"2015","journal-title":"J Assist Reprod Genet"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)60514-7","article-title":"Serum progesterone concentrations on the day of HCG administration cannot predict pregnancy in assisted reproduction cycles","volume":"8","author":"Martinez","year":"2004","journal-title":"Reprod BioMed Online"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmm007","article-title":"Is progesterone elevation on the day of human chorionic gonadotrophin administration associated with the probability of pregnancy in in vitro fertilization? 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