{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:40:21Z","timestamp":1791906021047,"version":"4.3.4"},"reference-count":92,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T00:00:00Z","timestamp":1687737600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p><jats:italic>In vitro<\/jats:italic> oocyte maturation (IVM) has been used worldwide. Despite the long-term implementation, the uptake of this procedure to complement current <jats:italic>in vitro<\/jats:italic> fertilization (IVF) remains low. The main reason is likely due to the non-synchronization of protocol and definition criteria, leading to difficulty in collective proper outcome data worldwide and, thus, lack of understanding of the exact IVM procedure. The review aims to consolidate the current clinical practice of IVM by dissecting relevant publications to be tailored for a current spectrum of clinical practice. Nevertheless, the background theories of oocyte maturation were also explored to provide a comprehensive understanding of the basis of IVM theories. Additional discussion of other potential uses of IVM in the future, such as in ovarian tissue cryopreservation known as OTO-IVM for fertility preservation and among women with diminished ovarian reserve, was also explored. Otherwise, future collaboration among all IVM centers is paramount for better collection of clinical data to provide valid recommendations for IVM in clinical practice, especially in molecular integrity and possible DNA alteration if present for IVM offspring outcome safety purposes.<\/jats:p>","DOI":"10.3389\/fendo.2023.1192180","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T13:18:40Z","timestamp":1687958320000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["The spectrum of in vitro maturation in clinical practice: the current insight"],"prefix":"10.3389","volume":"14","author":[{"given":"Mohd Faizal","family":"Ahmad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjanu Hikmah","family":"Elias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norazilah","family":"Mat Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Azrai","family":"Abu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saiful Effendi","family":"Syafruddin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ani Amelia","family":"Zainuddin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nao","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Kadir","family":"Abdul Karim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,6,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S1937-6448(08)00807-1","article-title":"Oocyte quality and maternal control of development","volume":"268","author":"Mtango","year":"2008","journal-title":"Int Rev Cell Mol Biol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(65)92903-x","article-title":"Maturation in vitro of human ovarian oocytes","volume":"2","author":"Edwards","year":"1965","journal-title":"Lancet"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.21.2.0394","article-title":"Initial and cyclic recruitment of ovarian follicles","volume":"21","author":"McGee","year":"2000","journal-title":"Endocr Rev"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-015-0528-9","article-title":"In vitro maturation (IVM) of oocytes recovered from ovariectomy specimens in the laboratory: a promising \"ex vivo\" method of oocyte cryopreservation resulting in the first report of an ongoing pregnancy in Europe","volume":"32","author":"Segers","year":"2015","journal-title":"J Assist Reprod Genet"},{"key":"B5","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1055\/s-0030-1268701","article-title":"The promise of in vitro maturation in assisted reproduction and fertility preservation","volume":"29","author":"Smitz","year":"2011","journal-title":"Semin Reprod Med"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.2217\/whe-2016-0019","article-title":"Improving fertility preservation for girls and women by coupling oocyte in vitro maturation with existing strategies","volume":"12","author":"Wang","year":"2016","journal-title":"Womens Health (Lond)"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1177\/17455057221114269","article-title":"Twenty-first century oocyte cryopreservation-in vitro maturation of immature oocytes from ovarian tissue cryopreservation in cancer patients: a systematic review","volume":"18","author":"Mohd Faizal","year":"2022","journal-title":"Womens Health (Lond)"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-010-9490-8","article-title":"Fertilization outcome, embryo development and birth after unstimulated IVM","volume":"28","author":"Bos-Mikich","year":"2011","journal-title":"J Assist Reprod Genet"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.03.059","article-title":"In vitro maturation and fertilization of oocytes from unstimulated ovaries in infertile women with polycystic ovary syndrome","volume":"91","author":"Zhao","year":"2009","journal-title":"Fertil Steril"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-021-02263-5","article-title":"Perspectives on the development and future of oocyte IVM in clinical practice","volume":"38","author":"De Vos","year":"2021","journal-title":"J Assist Reprod Genet"},{"key":"B11","doi-asserted-by":"crossref","DOI":"10.1002\/ar.1090750410","article-title":"The comparative behavior of mammalian eggs in vivo and in vitro. 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