{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T17:45:17Z","timestamp":1793900717248,"version":"4.8.0"},"reference-count":66,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T00:00:00Z","timestamp":1688515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Male infertility is a multifaceted issue that has gained scientific interest due to its increasing rate. Studies have demonstrated that oxidative stress is involved in male infertility development. Furthermore, metabolic disorders, including obesity, diabetes, hypo- and hyperthyroidism, are risk factors for male infertility, and oxidative stress is believed to contribute to this association. Melatonin, functioning as an oxidative scavenger, may represent a promising therapeutic approach for the prevention and treatment of metabolic disorder-associated male infertility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>We systematically searched three online databases (PubMed, Scopus, and Web of Science) for studies that evaluated the effects of melatonin therapy on metabolic disorders-induce infertility in male rodents. The favorable outcomes were histopathological parameters of testicular tissue, reproductive hormones, and markers of oxidative stress. Then, meta-analyses were done for each outcome. The results are reported as standardized mean difference (Cohen\u2019s d) and 95% confidence interval.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>24 studies with 31 outcomes were included. Rats and mice were the subjects. Studies have employed obesity, diabetes, hypothyroidism, hyperthyroidism, hyperlipidemia, and food deprivation as metabolic disorders. To induce these disorders, a high-fat diet, high\u2010fructose diet, leptin, streptozotocin, alloxan, carbimazole, and levothyroxine were used. The outcomes included histopathologic characteristics (abnormal sperm morphology, apoptotic cells, apoptotic index, Johnsen\u2019s testicular biopsy score, seminiferous epithelial height, tubular basement membrane thickness, tubular diameter, sperm count, and motility), weight-related measurements (absolute epididymis, testis, and body weight, body weight gain, epididymal adipose tissue weight, and relative testis to body weight), hormonal characteristics (androgen receptor expression, serum FSH, LH, and testosterone level), markers of oxidative stress (tissue and serum GPx and MDA activity, tissue CAT, GSH, and SOD activity), and exploratory outcomes (serum HDL, LDL, total cholesterol, triglyceride, and blood glucose level). The overall pooled effect sizes were statistically significant for all histopathological characteristics and some markers of oxidative stress.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Melatonin can reduce damage to male rodents\u2019 gonadal tissue and improve sperm count, motility, and morphology in metabolic diseases. Future clinical studies and randomized controlled trials are needed to evaluate the safety and effectiveness of melatonin for male infertility in patients with metabolic diseases.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2023.1202560","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T17:39:43Z","timestamp":1688578783000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Protective effects of melatonin against oxidative stress induced by metabolic disorders in the male reproductive system: a systematic review and meta-analysis of rodent models"],"prefix":"10.3389","volume":"14","author":[{"given":"Niloofar","family":"Dehdari Ebrahimi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Sadeghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moein","family":"Ala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Ebrahimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Pakbaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negar","family":"Azarpira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,7,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.2017.0339","article-title":"Urogenital infection as a risk factor for Male infertility","volume":"114","author":"Schuppe","year":"2017","journal-title":"Dtsch Arztebl Int"},{"key":"B2","first-page":"25","article-title":"Comparison of knowledge and attitude towards reproductive donation procedures between recipient and non-recipient infertile couples at mashhad infertility center","volume":"3","author":"Jafari","year":"2015","journal-title":"J Torbat Heydariyeh Univ Med Sci"},{"key":"B3","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s12958-015-0032-1","article-title":"A unique view on male infertility around the globe","volume":"13","author":"Agarwal","year":"2015","journal-title":"Reprod Biol Endocrinol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00428","article-title":"Effects of metabolic syndrome on semen quality and circulating sex hormones: a systematic review and meta-analysis","volume":"11","author":"Zhao","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B5","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/s13098-021-00728-2","article-title":"Association of diabetes and obesity with sperm parameters and testosterone levels: a meta-analysis","volume":"13","author":"Zhong","year":"2021","journal-title":"Diabetol Metab Syndr"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac458","article-title":"Subclinical hypothyroidism and sperm DNA fragmentation: a cross-sectional study of 5401 men seeking infertility care","volume":"107","author":"Zhao","year":"2022","journal-title":"J Clin Endocrinol Metab"},{"key":"B7","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1515\/hmbci-2015-0054","article-title":"A link between hypothyroidism, obesity and male reproduction","volume":"25","author":"Aiceles","year":"2016","journal-title":"Hormone Mol Biol Clin Invest"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2014.10.006","article-title":"Metabolic syndrome and infertility in men","volume":"29","author":"Morrison","year":"2015","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"B9","article-title":"Physiology of the pineal gland and melatonin","volume-title":"Endotext","author":"Arendt","year":"2000"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1080\/07420528.2020.1727918","article-title":"Exposure by males to light emitted from media devices at night is linked with decline of sperm quality and correlated with sleep quality measures","volume":"37","author":"Green","year":"2020","journal-title":"Chronobiol Int"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1089\/ict.2022.29025.klu","article-title":"Melatonin beyond sleep, part I: an overview","volume":"28","author":"Lucius","year":"2022","journal-title":"Integr Complement Therapies"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2010.00822.x","article-title":"High endogenous melatonin concentrations enhance sperm quality and short-term in vitro exposure to melatonin improves aspects of sperm motility","volume":"50","author":"Ortiz","year":"2011","journal-title":"J Pineal Res"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/0009-9120(92)80056-M","article-title":"Putative melatonin receptor in human spermatozoa","volume":"25","author":"van Vuuren","year":"1992","journal-title":"Clin Biochem"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2020.8678","article-title":"Men with idiopathic oligoasthenoteratozoospermia exhibit lower serum and seminal plasma melatonin levels: comparative effect of night-light exposure with fertile males","volume":"20","author":"Hassan","year":"2020","journal-title":"Exp Ther Med"},{"key":"B15","doi-asserted-by":"publisher","first-page":"105210","DOI":"10.1016\/j.phrs.2020.105210","article-title":"Effect of melatonin supplementation on oxidative stress parameters: a systematic review and meta-analysis","volume":"161","author":"Morvaridzadeh","year":"2020","journal-title":"Pharmacol Res"},{"key":"B16","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/s12958-022-00977-4","article-title":"Protective effect of melatonin on alleviating early oxidative stress induced by DOX in mice spermatogenesis and sperm quality maintaining","volume":"20","author":"Zi","year":"2022","journal-title":"Reprod Biol Endocrinol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"e14242","DOI":"10.1111\/and.14242","article-title":"Melatonin ameliorates endocrine dysfunction and defective sperm integrity associated with high-fat diet-induced obesity in male wistar rats","volume":"54","author":"Oladele","year":"2022","journal-title":"Andrologia"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12158","article-title":"Melatonin intake since weaning ameliorates steroidogenic function and sperm motility of streptozotocin-induced diabetic rats","volume":"4","author":"da Costa","year":"2016","journal-title":"Andrology"},{"key":"B19","doi-asserted-by":"publisher","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1123999","article-title":"Protective effects of melatonin against physical injuries to testicular tissue: a systematic review and meta-analysis of animal models","volume":"14","author":"Dehdari Ebrahimi","year":"2023","journal-title":"Front Endocrinol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1119553","article-title":"Protective effects of melatonin against the toxic effects of environmental pollutants and heavy metals on testicular tissue: a systematic review and meta-analysis of animal studies","volume":"14","author":"Dehdari Ebrahimi","year":"2023","journal-title":"Front Endocrinol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1186\/s13643-016-0384-4","article-title":"Rayyan\u2013a web and mobile app for systematic reviews","volume":"5","author":"Ouzzani","year":"2016","journal-title":"Systematic Rev"},{"key":"B23","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/1471-2288-14-43","article-title":"SYRCLE\u2019s risk of bias tool for animal studies","volume":"14","author":"Hooijmans","year":"2014","journal-title":"BMC Med Res Methodol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"B25","doi-asserted-by":"crossref","DOI":"10.1002\/9781119536604","volume-title":"Cochrane handbook for systematic reviews of interventions","author":"Higgins JPT","year":"2019"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1177\/0962280216669183","article-title":"Optimally estimating the sample mean from the sample size, median, mid-range, and\/or mid-quartile range","volume":"27","author":"Luo","year":"2018","journal-title":"Stat Methods Med Res"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1429","article-title":"Optimally estimating the sample standard deviation from the five-number summary","volume":"11","author":"Shi","year":"2020","journal-title":"Res Synth Methods"},{"key":"B28","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1038\/s41419-018-0956-4","article-title":"Melatonin attenuates detrimental effects of diabetes on the niche of mouse spermatogonial stem cells by maintaining leydig cells","volume":"9","author":"Du","year":"2018","journal-title":"Cell Death Dis"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.2012.01272.x","article-title":"Melatonin prevents testicular damage in hyperlipidaemic mice","volume":"44","author":"Zhang","year":"2012","journal-title":"Andrologia"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1111\/and.13323","article-title":"Melatonin appears to protect against steroidogenic collapse in both mice fed with high-fat diet and H(2) O(2) -treated TM3 cells","volume":"51","author":"Chen","year":"2019","journal-title":"Andrologia"},{"key":"B31","article-title":"The melatonin attenuates alloxan induced post-diabetic testicular damage and oxidative effects in rats","volume-title":"Kafkas Universitesi Veteriner Fakultesi Dergisi","author":"Akman","year":"2015"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.4103\/1008-682x.183379","article-title":"Melatonin ameliorates the adverse effects of leptin on sperm","volume":"19","author":"Almabhouh","year":"2017","journal-title":"Asian J Androl"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1111\/and.12814","article-title":"Adverse effects of leptin on histone-to-protamine transition during spermatogenesis are prevented by melatonin in sprague-dawley rats","volume":"50","author":"Almabhouh","year":"2018","journal-title":"Andrologia"},{"key":"B34","doi-asserted-by":"publisher","first-page":"151559","DOI":"10.1016\/j.acthis.2020.151559","article-title":"Protective action of melatonin on diabetic rat testis at cellular, hormonal and immunohistochemical levels","volume":"122","author":"Alves","year":"2020","journal-title":"Acta Histochem"},{"key":"B35","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1111\/j.1745-7262.2006.00177.x","article-title":"Effects of melatonin on lipid peroxidation and antioxidant enzymes in streptozotocin-induced diabetic rat testis","volume":"8","author":"Armagan","year":"2006","journal-title":"Asian J Androl"},{"key":"B36","doi-asserted-by":"publisher","first-page":"e13327","DOI":"10.1111\/and.13327","article-title":"The effects of high-fructose corn syrup consumption on testis physiopathology-the ameliorative role of melatonin","volume":"51","author":"Aslankoc","year":"2019","journal-title":"Andrologia"},{"key":"B37","doi-asserted-by":"publisher","first-page":"836121","DOI":"10.1155\/2013\/836121","article-title":"Weight loss and melatonin reduce obesity-induced oxidative damage in rat testis","author":"Atilgan","year":"2013","journal-title":"Adv Urol 2013"},{"key":"B38","article-title":"Effects of melatonin treatment on the spermatogenesis and serum inflammatory cytokine levels in diabetic rats","volume":"26","author":"Bozkurt","year":"2019","journal-title":"Ann Med Res (Inonu University School of Medicine)"},{"key":"B39","doi-asserted-by":"publisher","first-page":"614579","DOI":"10.1155\/2015\/614579","article-title":"Effect of melatonin intake on oxidative stress biomarkers in Male reproductive organs of rats under experimental diabetes","volume":"2015","author":"Gobbo","year":"2015","journal-title":"Oxid Med Cell Longev"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1159\/000118032","article-title":"Effect of melatonin on testicular damage in streptozotocin-induced diabetes rats","volume":"40","author":"Guneli","year":"2008","journal-title":"Eur Surg Res"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.21608\/ejhm.2007.17718","article-title":"Evaluation of the influence of each of melatonin and chromium against diabetes-induced alteration in the testis of albino rats using light and electron microscopies","volume":"27","author":"Hassen","year":"2007","journal-title":"Egyptian J Hosp Med"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2020-0499","article-title":"Comparative protective effects of n-acetylcysteine and melatonin against obesity-induced testicular dysfunction in rats","volume":"99","author":"Khalil","year":"2021","journal-title":"Can J Physiol Pharmacol"},{"key":"B43","article-title":"Hyperthyroidism causes lipid peroxidation in kidney and testis tissues of rats: protective role of melatonin","volume":"26","author":"Mogulkoc","year":"2005","journal-title":"Neuro Endocrinol Lett"},{"key":"B44","doi-asserted-by":"publisher","first-page":"52","DOI":"10.21608\/EJH.2017.3701","article-title":"Effects of simultaneous melatonin administration on the testis of the experimentally induced hyper- and hypothyroidism in the adult Male albino rat","volume":"40","author":"Mohamed","year":"2017","journal-title":"Egyptian J Histol"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1071\/RD14432","article-title":"Food deprivation and social inequality may lead to oxidative damage: a study on the preventive role of melatonin in the male rat reproductive system","volume":"28","author":"Nasiraei-Moghadam","year":"2015","journal-title":"Reprod Fertil Dev"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.02.040","article-title":"Combined treatment with melatonin and insulin improves glycemic control, white adipose tissue metabolism and reproductive axis of diabetic male rats","volume":"199","author":"Oliveira","year":"2018","journal-title":"Life Sci"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-020-10682-7","article-title":"Melatonin enhances antioxidant defenses but could not ameliorate the reproductive disorders in induced hyperthyroidism model in male rats","volume":"28","author":"Ramadan","year":"2021","journal-title":"Environ Sci Pollut Res Int"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1111\/and.13639","article-title":"Melatonin prevents deterioration of erectile function in streptozotocin-induced diabetic rats via sirtuin-1 expression","volume":"52","author":"Sahan","year":"2020","journal-title":"Andrologia"},{"key":"B49","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.theriogenology.2022.02.029","article-title":"Melatonin supplementation preserves testicular function by attenuating lactate production and oxidative stress in high fat diet-induced obese rat model","volume":"187","author":"Saidi","year":"2022","journal-title":"Theriogenology"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2005.00624.x","article-title":"Melatonin hormone profile in infertile males","volume":"29","author":"Awad","year":"2006","journal-title":"Int J Androl"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.2147\/NSS.S235136","article-title":"Association between sleep quality and semen parameters and reproductive hormones: a cross-sectional study in zhejiang, China","volume":"12","author":"Du","year":"2020","journal-title":"Nat Sci Sleep"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12690","article-title":"Melatonin protects mouse testes from palmitic acid-induced lipotoxicity by attenuating oxidative stress and DNA damage in a SIRT1-dependent manner","volume":"69","author":"Xu","year":"2020","journal-title":"J Pineal Res"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2020.e05584","article-title":"Cinnamomum zeylanicum alleviate testicular damage induced by high fat diet in albino rats; histological and ultrastructural studies","volume":"6","author":"Arisha","year":"2020","journal-title":"Heliyon"},{"key":"B54","doi-asserted-by":"publisher","first-page":"6075","DOI":"10.3390\/molecules27186075","article-title":"Protective effect of portulaca oleracea on streptozotocin-induced type I diabetes-associated reproductive system dysfunction and inflammation","volume":"27","author":"Rakhshandeh","year":"2022","journal-title":"Molecules"},{"key":"B55","doi-asserted-by":"publisher","first-page":"325","DOI":"10.18502\/ijrm.v17i5.4600","article-title":"Effects of l-carnitine on the sperm parameters disorders, apoptosis of spermatogenic cells and testis histopathology in diabetic rats","volume":"17","author":"Mardanshahi","year":"2019","journal-title":"Int J Reprod BioMed"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2019.09.006","article-title":"Crosstalk between sertoli and germ cells in male fertility","volume":"26","author":"Wu","year":"2020","journal-title":"Trends Mol Med"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.02.040","article-title":"Combined treatment with melatonin and insulin improves glycemic control, white adipose tissue metabolism and reproductive axis of diabetic male rats","volume":"199","author":"Oliveira","year":"2018","journal-title":"Life Sci"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-0022","article-title":"Minireview: kisspeptin\/neurokinin b\/dynorphin (KNDy) cells of the arcuate nucleus: a central node in the control of gonadotropin-releasing hormone secretion","volume":"151","author":"Lehman","year":"2010","journal-title":"Endocrinology"},{"key":"B59","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.mce.2015.05.039","article-title":"Melatonin replacement restores the circadian behavior in adult rat leydig cells after pinealectomy","volume":"413","author":"Baburski","year":"2015","journal-title":"Mol Cell Endocrinol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"447","DOI":"10.3390\/molecules23020447","article-title":"Melatonin regulates the synthesis of steroid hormones on male reproduction: a review","volume":"23","author":"Yu","year":"2018","journal-title":"Molecules"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioab046","article-title":"Melatonin promotes male reproductive performance and increases testosterone synthesis in mammalian leydig cells","volume":"104","author":"Yang","year":"2021","journal-title":"Biol Reprod"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047-2927.2014.00207.x","article-title":"Melatonin in testes of infertile men: evidence for anti-proliferative and anti-oxidant effects on local macrophage and mast cell populations","volume":"2","author":"Rossi","year":"2014","journal-title":"Andrology"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-020-10682-7","article-title":"Melatonin enhances antioxidant defenses but could not ameliorate the reproductive disorders in induced hyperthyroidism model in male rats","volume":"28","author":"Ramadan","year":"2021","journal-title":"Environ Sci Pollut Res"},{"key":"B64","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/s12958-022-00991-6","article-title":"Melatonin ameliorates diabetic hyperglycaemia-induced impairment of leydig cell steroidogenic function through activation of SIRT1 pathway","volume":"20","author":"Wang","year":"2022","journal-title":"Reprod Biol Endocrinol"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gau080","article-title":"Melatonin alters the glycolytic profile of sertoli cells: implications for male fertility","volume":"20","author":"Rocha","year":"2014","journal-title":"Mol Hum Reprod"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1242\/dev.110627","article-title":"SirT1 is required in the male germ cell for differentiation and fecundity in mice","volume":"141","author":"Bell","year":"2014","journal-title":"Development"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2023.1202560\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T17:39:52Z","timestamp":1688578792000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2023.1202560\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,5]]},"references-count":66,"alternative-id":["10.3389\/fendo.2023.1202560"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2023.1202560","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,5]]},"article-number":"1202560"}}