{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:47:17Z","timestamp":1762177637406,"version":"3.41.2"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The clinical manifestations of multiple myeloma (MM) and bone metastatic tumor are both systemic bone pain, which is difficult to distinguish from imaging manifestations, leading to misdiagnosis and missed diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case summary<\/jats:title><jats:p>We reported a man with a unique case whose tumors were MM with bone metastatic tumor of clear cell renal cell carcinoma (CCRCC). Computed tomography (CT) showed multifocal osteolytic bone destruction, while magnetic resonance imaging (MRI) showed multifocal bone marrow infiltration with soft tissue mass. Pathology and immunohistochemistry established the diagnosis of the coexistence of myeloma with bone metastatic tumor of CCRCC in the spine. Immunotherapy and systemic chemotherapy were adopted in the clinic, and vertebral decompression was performed after anemia was corrected. This case with MM and bone metastatic tumor of CCRCC received radiotherapy and immunotherapy and acquired satisfying outcome after 1 year of follow-up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>It is difficult to differentiate MM and bone metastatic tumor on imaging, especially when there are bone lesions at the same time, which is an easily missed diagnosis and needs to be comprehensively evaluated in combination with functional procedures, clinical laboratory tests, and histopathology.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2023.1206368","type":"journal-article","created":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T16:59:06Z","timestamp":1701536346000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Multiple myeloma following bone metastasis of renal cell carcinoma: a case report"],"prefix":"10.3389","volume":"14","author":[{"given":"Hong","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengnan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,12,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.2128","article-title":"Global burden of multiple myeloma: a systematic analysis for the global burden of disease study 2016","volume":"4","author":"Cowan","year":"2018","journal-title":"JAMA Oncol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.0208860","article-title":"Differentiation of multiple myeloma and metastases: Use of axial diffusion-weighted MR imaging in addition to standard MR imaging at 3T","volume":"13","author":"Park","year":"2018","journal-title":"PloS One"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2014-204778","article-title":"Plasmablastic multiple myeloma following clear cell renal cell carcinoma","volume":"2014","author":"Padhi","year":"2014","journal-title":"BMJ Case Rep"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20190891","article-title":"Application of monoexponential, biexponential, and stretched-exponential models of diffusion-weighted magnetic resonance imaging in the differential diagnosis of metastases and myeloma in the spine-Univariate and multivariate analysis of related parameters","volume":"93","author":"Xing","year":"2020","journal-title":"Br J Radiol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/bjh.15210","article-title":"Resistance to proteasome inhibitors and other targeted therapies in myeloma","volume":"182","author":"Wallington\u2212Beddoe","year":"2018","journal-title":"Br J Haematol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-020-05684-0","article-title":"Bone metastases: a comprehensive review of the literature","volume":"47","author":"Migliorini","year":"2020","journal-title":"Mol Biol Rep"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2010.09892.x","article-title":"The association between renal cell carcinoma and multiple myeloma: insights from population-based data","volume":"108","author":"Ojha","year":"2011","journal-title":"BJU Int"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2012.10.006","article-title":"Differentiation of myeloma and metastatic cancer in the spine using dynamic contrast-enhanced MRI","volume":"31","author":"Lang","year":"2013","journal-title":"Magn Reson Imaging"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2019.09.622","article-title":"Minimal residual disease status as a surrogate endpoint for progression\u2212free survival in newly diagnosed multiple myeloma studies: a meta\u2212analysis","volume":"20","author":"Avet-Loiseau","year":"2020","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.01231","article-title":"GEM\/PETHEMA Cooperative Study Group. 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