{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:08:20Z","timestamp":1793830100826,"version":"4.6.1"},"reference-count":111,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T00:00:00Z","timestamp":1691107200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Bone diseases are common among middle-aged and elderly people, and harm to activities of daily living (ADL) and quality of life (QOL) for patients. It is crucial to search for key regulatory factors associated with the development of bone diseases and explore potential therapeutic targets for bone diseases. Irisin is a novel myokine that has been discovered in recent years. Accumulating evidence indicates that irisin has beneficial effects in the treatment of various diseases such as metabolic, cardiovascular and neurological disorders, especially bone-related diseases. Recent studies had shown that irisin plays the role in various bone diseases such as osteoarthritis, osteoporosis and other bone diseases, suggesting that irisin may be a potential molecule for the prevention and treatment of bone diseases. Therefore, in this review, by consulting the related domestic and international literature of irisin and bone diseases, we summarized the specific regulatory mechanisms of irisin in various bone diseases, and provided a systematic theoretical basis for its application in the diagnosis and treatment of the bone diseases.<\/jats:p>","DOI":"10.3389\/fendo.2023.1212892","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T12:21:42Z","timestamp":1691151702000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Role of irisin in bone diseases"],"prefix":"10.3389","volume":"14","author":[{"given":"Ruobing","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxin","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,8,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5484.1508","article-title":"Therapeutic approaches to bone diseases","author":"Rodan","year":"2000","journal-title":"Sci (New York N.Y"},{"key":"B2","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/s41574-020-0341-0","article-title":"Pathogenesis of glucocorticoid-induced osteoporosis and options for treatment","volume":"16","author":"Chotiyarnwong","year":"2020","journal-title":"Nat Rev Endocrinol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s11914-014-0209-0","article-title":"Endocrine crosstalk between muscle and bone","volume":"12","author":"Brotto","year":"2014","journal-title":"Curr osteoporosis Rep"},{"key":"B4","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/nrendo.2012.49","article-title":"Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nature reviews","volume":"8","author":"Pedersen","year":"2012","journal-title":"Endocrinology"},{"key":"B5","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1038\/bonekey.2016.48","article-title":"Effects of myokines on bone","volume":"5","author":"Kaji","year":"2160","journal-title":"BoneKEy Rep"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/bonekey.2012.60","article-title":"The skeletal muscle secretome: an emerging player in muscle-bone crosstalk","volume":"1","author":"Hamrick","year":"2012","journal-title":"BoneKEy Rep"},{"key":"B7","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1007\/s11914-020-00599-y","article-title":"Muscle, bone, and fat crosstalk: the biological role of myokines, osteokines, and adipokines","volume":"18","author":"Kirk","year":"2020","journal-title":"Curr osteoporosis Rep"},{"key":"B8","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nature10777","article-title":"A PGC1-\u03b1-dependent myokine that drives brown-fat-like development of white fat and thermogenesis","volume":"481","author":"Bostr\u00f6m","year":"2012","journal-title":"Nature."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3390\/cells8050451","article-title":"Irisin and bone: from preclinical studies to the evaluation of its circulating levels in different populations of human subjects","volume":"8","author":"Colaianni","year":"2019","journal-title":"Cells"},{"key":"B10","doi-asserted-by":"publisher","first-page":"12157","DOI":"10.1073\/pnas.1516622112","article-title":"The myokine irisin increases cortical bone mass","volume":"112","author":"Colaianni","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21041259","article-title":"Recombinant irisin prevents the reduction of osteoblast differentiation induced by stimulated microgravity through increasing \u03b2-catenin expression","volume":"21","author":"Chen","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202000216R","article-title":"Irisin prevents microgravity-induced impairment of osteoblast differentiation in vitro during the space flight CRS-14 mission","volume":"34","author":"Silvia","year":"2020","journal-title":"FASEB J"},{"key":"B13","doi-asserted-by":"publisher","first-page":"2811","DOI":"10.1038\/s41598-017-02557-8","article-title":"Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice","volume":"7","author":"Colaianni","year":"2015","journal-title":"Sci Rep"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060563","article-title":"FNDC5\/irisin is not only a myokine but also an adipokine","volume":"8","author":"Roca-Rivada","year":"2013","journal-title":"PloS One"},{"key":"B15","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.cmet.2013.12.017","article-title":"Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans","volume":"19","author":"Lee","year":"2014","journal-title":"Cell Metab"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511x-11-142","article-title":"Conjugated linoleic acid or omega 3 fatty acids increase mitochondrial biosynthesis and metabolism in skeletal muscle cells","volume":"11","author":"Vaughan","year":"2012","journal-title":"Lipids Health disease."},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2013.09.011","article-title":"Alterations of irisin concentrations in saliva and serum of obese and normal-weight subjects, before and after 45 min of a Turkish bath or running","volume":"50","author":"Aydin","year":"2014","journal-title":"Peptides."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1016\/j.cell.2018.10.025","article-title":"Irisin mediates effects on bone and fat via \u03b1V integrin receptors","volume":"175","author":"Kim","year":"2018","journal-title":"Cell."},{"key":"B19","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/s0092-8674(02)00971-6","article-title":"Integrins: bidirectional, allosteric signaling machines","volume":"110","author":"Hynes","year":"2002","journal-title":"Cell."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.111.4.425","article-title":"The alphavbeta5 integrin functions as an endocytic receptor for vitronectin","volume":"111","author":"Memmo","year":"1998","journal-title":"J Cell science."},{"key":"B21","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1155\/2018\/7816806","article-title":"Irisin a novel metabolic biomarker: present knowledge and future directions","volume":"1","author":"Martinez Munoz","year":"2018","journal-title":"Int J endocrinology."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1016\/j.jdiacomp.2016.07.020","article-title":"Exenatide treatment increases serum irisin levels in patients with obesity and newly diagnosed type 2 diabetes","volume":"30","author":"Liu","year":"2016","journal-title":"J Diabetes its complications."},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1007\/s40519-017-0431-8","article-title":"Does iris(in) bring bad news or good news","volume":"23","author":"Buscemi","year":"2018","journal-title":"Eating weight disorders: EWD."},{"key":"B24","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1055\/s-0042-108730","article-title":"Lower circulating irisin level in patients with diabetes mellitus: A systematic review and meta-analysis","volume":"48","author":"Du","year":"2016","journal-title":"Hormone Metab Res = Hormon- und Stoffwechselforschung = Hormones metabolisme."},{"key":"B25","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1007\/s10753-017-0685-3","article-title":"Irisin alleviates advanced glycation end products-induced inflammation and endothelial dysfunction via inhibiting ROS-NLRP3 inflammasome signaling","volume":"41","author":"Deng","year":"2018","journal-title":"Inflammation."},{"key":"B26","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.molimm.2017.09.014","article-title":"Irisin protects against neuronal injury induced by oxygen-glucose deprivation in part depends on the inhibition of ROS-NLRP3 inflammatory signaling pathway","volume":"91","author":"Peng","year":"2017","journal-title":"Mol Immunol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"e0158038","DOI":"10.1371\/journal.pone.0158038","article-title":"Protective effect of irisin on atherosclerosis via suppressing oxidized low density lipo-protein induced vascular inflammation and endothelial dysfunction","volume":"11","author":"Zhang","year":"2016","journal-title":"PloS One"},{"key":"B28","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1002\/jcp.29894","article-title":"Irisin deficiency disturbs bone metabolism","volume":"236","author":"Zhu","year":"2021","journal-title":"J Cell Physiol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1155\/2020\/5720360","article-title":"Biochemical signals mediate the crosstalk between cartilage and bone in osteoar-thritis","volume":"1","author":"Zhou","year":"2020","journal-title":"BioMed Res Int"},{"key":"B30","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.coph.2015.03.004","article-title":"Emerging targets in osteoarthritis therapy","volume":"22","author":"Goldring","year":"2015","journal-title":"Curr Opin Pharmacol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1089\/gtmb.2015.0170","article-title":"Association of irisin and CRP levels with the radiographic severity of knee osteoar-thritis","volume":"20","author":"Mao","year":"2015","journal-title":"Genet testing Mol biomarkers."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.703670","article-title":"Roles and mechanisms of irisin in attenuating pathological features of osteoarthritis","volume":"9","author":"Li","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15020585","article-title":"Irisin role in chondrocyte 3D culture differentiation and its possible applications","volume":"15","author":"Posa","year":"2023","journal-title":"Pharmaceutics."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.4331\/wjbc.v5.i3.321","article-title":"Mnk kinase pathway: Cellular functions and biological outcomes","volume":"5","author":"Joshi","year":"2014","journal-title":"World J Biol Chem"},{"key":"B35","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1254\/jphs.09076fp","article-title":"The chondroprotective agent ITZ-1 inhibits interleukin-1beta-induced matrix metalloproteinase-13 production and suppresses nitric oxide-induced chondrocyte death","volume":"110","author":"Kimura","year":"2009","journal-title":"J Pharmacol Sci"},{"key":"B36","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1002\/art.23176","article-title":"Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II","volume":"58","author":"Lawrence","year":"2008","journal-title":"Arthritis rheumatism."},{"key":"B37","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1136\/ard.2005.041855","article-title":"PD-0200347, an alpha2delta ligand of the voltage gated calcium channel, inhibits in vivo activation of the Erk1\/2 pathway in osteoarthritic chondrocytes: a PKCalpha dependent effect","volume":"65","author":"Boileau","year":"2006","journal-title":"Ann rheumatic diseases."},{"key":"B38","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1002\/jbmr.3944","article-title":"Irisin prevents disuse-induced osteocyte apoptosis","volume":"35","author":"Storlino","year":"2020","journal-title":"J Bone mineral Res Off J Am Soc Bone Mineral Res"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2020.115573","article-title":"Irisin inhibits osteocyte apoptosis by activating the Erk signaling pathway in vitro and attenuates ALCT-induced osteoarthritis in mice","volume":"141","author":"He","year":"2020","journal-title":"Bone."},{"key":"B40","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/nrrheum.2010.196","article-title":"Role of proinflammatory cytokines in the patho-physiology of osteoarthritis","volume":"7","author":"Kapoor","year":"2010","journal-title":"Nat Rev Rheumatol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"584","DOI":"10.3969\/j.issn.1671-0770","article-title":"Experimental study on the regulation of p38MAPK pathway by irisin-targeted TDP-43 for the relief of osteoarthritis","volume":"43","author":"Feng","year":"2021","journal-title":"Anatomical Stud"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2004.19.4.567","article-title":"Prologation of c-Jun N-terminal kinase is associated with cell death induced by tumor necrosis factor alpha in human chondrocytes","volume":"19","author":"Yoon","year":"2004","journal-title":"J Korean Med science."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18040701","article-title":"Anti-inflammatory properties of irisin, mediator of physical activity, are connected with TLR4\/myD88 signaling pathway activation","volume":"18","author":"Mazur-Bialy","year":"2017","journal-title":"Int J Mol Sci"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3390\/cells9061478","article-title":"Irisin recovers osteoarthritic chondrocytes in vitro","volume":"9","author":"Vadal\u00e0","year":"2020","journal-title":"Cells."},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20246275","article-title":"NF-\u03baB signaling regulates physiological and pathological chondrogenesis","volume":"20","author":"Jimi","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.3892\/ijmm.2017.3177","article-title":"Isoliquiritigenin suppresses IL-1\u03b2 induced apoptosis and inflammation in chondrocyte-like ATDC5 cells by inhibiting NF-\u03baB and exerts chondroprotective effects on a mouse model of anterior cruciate ligament transection","volume":"40","author":"Ji","year":"2017","journal-title":"Int J Mol Med"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22126461","article-title":"Immunofluorescence Analysis of NF-kB and iNOS Expression in Different Cell Populations during Early and Advanced Knee Osteoarthritis","volume":"22","author":"Ostojic","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B48","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1155\/2022\/5215915","article-title":"Irisin activates M1 macrophage and suppresses Th2-type immune response in rats with pelvic inflammatory disease","volume":"1","author":"Zhang","year":"2022","journal-title":"Evidence-Based complementary Altern Med eCAM."},{"key":"B49","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1080\/10799893.2020.1808675","article-title":"Irisin alleviates LPS-induced liver injury and inflammation through inhibition of NLRP3 inflammasome and NF-\u03baB signaling","volume":"41","author":"Li","year":"2020","journal-title":"J receptor Signal transduction Res"},{"key":"B50","doi-asserted-by":"publisher","first-page":"6470","DOI":"10.26355\/eurrev_202006_21546","article-title":"Irisin alleviates renal injury caused by sepsis via the NF-\u03baB signaling pathway","volume":"24","author":"Jin","year":"2020","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2021.170688","article-title":"Irisin lowers blood pressure in Zucker diabetic rats by regulating the functions of renal angiotensin II type 1 receptor via the inhibition of the NF-\u03baB signaling pathway","volume":"147","author":"Huang","year":"2022","journal-title":"Peptides."},{"key":"B52","doi-asserted-by":"publisher","first-page":"2879","DOI":"10.3892\/etm.2020.8562","article-title":"Recombinant human irisin regulated collagen II, matrix metalloproteinase-13 and the Wnt\/\u03b2-catenin and NF-\u03baB signaling pathways in interleukin-1\u03b2-induced human SW1353 cells","volume":"19","author":"Li","year":"2020","journal-title":"Exp Ther Med"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.797855","article-title":"Mechanical stimulation protects against chondrocyte pyroptosis through irisin-induced suppression of PI3K\/akt\/NF-\u03baB signal pathway in osteoarthritis","volume":"10","author":"Jia","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"5753","DOI":"10.1111\/jcmm.13826","article-title":"Down-regulated in OA cartilage, SFMBT2 contributes to NF-\u03baB-mediated ECM degradation","volume":"22","author":"Hussain","year":"2018","journal-title":"J Cell Mol Med"},{"key":"B55","doi-asserted-by":"publisher","first-page":"6135","DOI":"10.1002\/jcp.26460","article-title":"Blocking PI3K\/AKT signaling inhibits bone sclerosis in subchondral bone and attenuates post-traumatic osteoarthritis","volume":"233","author":"Lin","year":"2018","journal-title":"J Cell Physiol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1002\/art.41152","article-title":"GRK5 inhibition attenuates cartilage degradation via decreased NF-\u03baB signaling","volume":"72","author":"Sueishi","year":"2020","journal-title":"Arthritis Rheumatol (Hoboken N.J.)."},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-14-235","article-title":"Mitochondrial respiratory chain dysfunction modulates metalloproteases -1, -3 and -13 in human normal chondrocytes in culture","volume":"14","author":"Cillero-Pastor","year":"2013","journal-title":"BMC musculoskeletal Disord"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aan5372","article-title":"Targeting mitochondrial responses to intra-articular fracture to prevent posttraumatic osteoarthritis","volume":"10","author":"Coleman","year":"2018","journal-title":"Sci Trans Med"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/j.joca.2020.03.018","article-title":"Mitochondrial biogenesis: a potential therapeutic target for osteoarthritis","volume":"28","author":"Blanco","year":"2020","journal-title":"Osteoarthritis cartilage."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1136\/annrheumdis-2016-210131","article-title":"Mitochondrial DNA haplogroups in-fluence the risk of incident knee osteoarthritis in OAI and CHECK cohorts. A meta-analysis and functional study","volume":"76","author":"Fern\u00e1ndez-Moreno","year":"2016","journal-title":"Ann rheumatic diseases."},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1002\/art.39025","article-title":"Autophagy activation and protection from mitochondrial dysfunction in human chondrocytes","volume":"67","author":"L\u00f3pez de","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s13395-020-00245-2","article-title":"Exercise enhances mitochondrial fission and mitophagy to improve myopathy following critical limb ischemia in elderly mice via the PGC1a\/FNDC5\/irisin pathway","volume":"10","author":"He","year":"2020","journal-title":"Skeletal muscle."},{"key":"B63","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.redox.2018.10.019","article-title":"Irisin alleviates liver is-chemia-reperfusion injury by inhibiting excessive mitochondrial fission, promoting mitochondrial biogenesis and decreasing oxidative stress","volume":"20","author":"Bi","year":"2019","journal-title":"Redox Biol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1155\/2021\/2989974","article-title":"Irisin attenuates oxidative stress, mitochondrial dysfunction, and apoptosis in the H9C2 cellular model of septic cardiomyopathy through augmenting fundc1-dependent mitophagy","volume":"1","author":"Jiang","year":"2019","journal-title":"Oxid Med Cell longevity."},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9090810","article-title":"Irisin mitigates oxidative stress, chondrocyte dysfunction and osteoarthritis development through regulating mitochondrial integrity and autophagy","volume":"9","author":"Wang","year":"2020","journal-title":"Antioxidants (Basel Switzerland)."},{"key":"B66","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1097\/00003086-200003000-00016","article-title":"Osteoporosis","volume":"372","author":"Lane","year":"2000","journal-title":"Clin orthopaedics related Res"},{"key":"B67","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/j.1447-0594.2008.00481.x","article-title":"Osteocytes in the pathogenesis of osteoporosis","volume":"8","author":"Ikeda","year":"2008","journal-title":"Geriatrics gerontology Int"},{"key":"B68","doi-asserted-by":"publisher","first-page":"14262","DOI":"10.1002\/jcb.28946","article-title":"Muscle-bone crosstalk and potential therapies for sar-co-osteoporosis","volume":"120","author":"Li","year":"2019","journal-title":"J Cell Biochem"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.52547\/rbmb.10.1.13","article-title":"Lower serum irisin levels are associated with increased osteoporosis and oxidative stress in postmenopausal","volume":"10","author":"Badr Roomi","year":"2021","journal-title":"Rep Biochem Mol Biol"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.6118\/jmm.2016.22.2.76","article-title":"Postmenopausal osteoporosis is associated with serum chemerin and irisin but not with apolipoprotein M levels","volume":"22","author":"Engin-\u00dcst\u00fcn","year":"2016","journal-title":"J menopausal Med"},{"key":"B71","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1097\/gme.0000000000001388","article-title":"Lower circulating irisin in middle-aged and older adults with osteoporosis: a systematic review and meta-analysis","volume":"26","author":"Zhou","year":"2019","journal-title":"Menopause (New York N.Y.)."},{"key":"B72","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1515\/med-2020-0215","article-title":"Circulating irisin is linked to bone mineral density in geriatric Chinese men","volume":"15","author":"Zhang","year":"2020","journal-title":"Open Med (Warsaw Poland)."},{"key":"B73","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s00774-019-01043-7","article-title":"Role of irisin in androgen-deficient muscle wasting and osteopenia in mice","volume":"38","author":"Iemura","year":"2020","journal-title":"J Bone mineral Metab"},{"key":"B74","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1155\/2021\/5570229","article-title":"Irisin has a protective role against osteoporosis in ovari-ectomized rats","volume":"1","author":"Morgan","year":"2021","journal-title":"BioMed Res Int"},{"key":"B75","doi-asserted-by":"publisher","first-page":"2777","DOI":"10.2337\/db21-0573","article-title":"Exercise-linked skeletal irisin ameliorates diabetes-associated osteoporosis by inhibiting the oxidative damage-dependent miR-150-FNDC5\/pyroptosis axis","volume":"71","author":"Behera","year":"2022","journal-title":"Diabetes."},{"key":"B76","doi-asserted-by":"publisher","first-page":"16056","DOI":"10.1038\/boneres.2016.56","article-title":"Exercise-induced irisin in bone and systemic irisin administration reveal new regulatory mechanisms of bone metabolism","volume":"5","author":"Zhang","year":"2016","journal-title":"Bone Res"},{"key":"B77","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1146\/annurev.cellbio.20.010403.113126","article-title":"The Wnt signaling pathway in development and disease","volume":"20","author":"Logan","year":"2004","journal-title":"Annu Rev Cell Dev Biol"},{"key":"B78","doi-asserted-by":"publisher","first-page":"2630","DOI":"10.1210\/en.2006-1372","article-title":"In vivo analysis of Wnt signaling in bone","volume":"148","author":"Glass","year":"2007","journal-title":"Endocrinology."},{"key":"B79","doi-asserted-by":"publisher","first-page":"144","DOI":"10.3877\/cma.j.issn.1674\u20431366.2019.03.003","article-title":"Effect of irisin on Sost gene expression and os-teogenic differentiation of rat bone marrow mesenchymal stem cells","volume":"13","author":"Mengting","year":"2019","journal-title":"Chin J Oral Med Res"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2020.155292","article-title":"Irisin promotes osteogenic differentiation of bone marrow mesenchymal stem cells by activating autophagy via the Wnt\/\/\u03b2-catenin signal pathway","volume":"136","author":"Chen","year":"2020","journal-title":"Cytokine."},{"key":"B81","doi-asserted-by":"publisher","first-page":"16744","DOI":"10.1074\/jbc.M114.628313","article-title":"The wnt inhibitor sclerostin is up-regulated by mechanical unloading in os-teocytes in vitro","volume":"290","author":"Spatz","year":"2015","journal-title":"J Biol Chem"},{"key":"B82","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1359\/jbmr.080325","article-title":"Berberine promotes osteoblast differentiation by Runx2 activation with p38 MAPK","volume":"23","author":"Lee","year":"2008","journal-title":"J Bone mineral Res Off J Am Soc Bone Mineral Res"},{"key":"B83","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1089\/scd.2007.0230","article-title":"Fibroblast growth factor-2 and -4 promote the prolif-eration of bone marrow mesenchymal stem cells by the activation of the PI3K-Akt and ERK1\/2 signaling pathways","volume":"17","author":"Choi","year":"2008","journal-title":"Stem Cells Dev"},{"key":"B84","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1007\/s00726-007-0003-8","article-title":"Taurine inhibits osteoblastic differentiation of vascular smooth muscle cells via the ERK pathway","volume":"34","author":"Liao","year":"2008","journal-title":"Amino Acids"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1038\/srep18732","article-title":"Irisin promotes osteoblast proliferation and differentiation via activating the MAP kinase signaling pathways","volume":"6","author":"Qiao","year":"2016","journal-title":"Sci Rep"},{"key":"B86","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1111\/odi.13307","article-title":"Irisin promotes cementoblast differentiation via p38 MAPK pathway","volume":"26","author":"Zhu","year":"2020","journal-title":"Oral diseases."},{"key":"B87","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.13406\/j.cnki.cyxb.002006","article-title":"Study of osteogenic differentiation of BMSCs under the effect of static and tensile forces by irisin","volume":"44","author":"Zewei","year":"2019","journal-title":"J Chongqing Med University."},{"key":"B88","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.cell.2011.07.030","article-title":"Autophagy and aging","volume":"146","author":"Rubinsztein","year":"2011","journal-title":"Cell."},{"key":"B89","doi-asserted-by":"publisher","first-page":"257","DOI":"10.19748\/j.cn.kqxf.1009-3761.2020.05.001","article-title":"In vitro studies on the promotion of osteotropic differentiation of aged mouse BMSCs by activation of autophagy by irisin","volume":"21","author":"Lei","year":"2020","journal-title":"J Oral Maxillofac Prosthetics."},{"key":"B90","doi-asserted-by":"publisher","first-page":"8673","DOI":"10.1073\/pnas.1324290111","article-title":"Up-regulation of glycolytic metabolism is re-quired for HIF1\u03b1-driven bone formation","volume":"111","author":"Regan","year":"2014","journal-title":"Proc Natl Acad Sci United States America."},{"key":"B91","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.bone.2018.05.013","article-title":"The bone anabolic effects of irisin are through preferential stimulation of aerobic glycolysis","volume":"114","author":"Zhang","year":"2018","journal-title":"Bone."},{"key":"B92","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.ijbiomac.2019.12.028","article-title":"The immunomodulatory role of irisin on osteogenesis via AMPK-mediated macrophage polarization","volume":"146","author":"Ye","year":"2020","journal-title":"Int J Biol macromolecules."},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201700983RR","article-title":"Irisin promotes proliferation but inhibits differentiation in osteoclast precursor cells","volume":"17","author":"Ma","year":"2018","journal-title":"FASEB J: Off Publ Feder-ation Am Societies Exp Biol"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.58172","article-title":"Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo","volume":"9","author":"Estell","year":"2020","journal-title":"eLife."},{"key":"B95","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.tips.2015.02.001","article-title":"Novel therapeutic targets in rheumatoid arthritis","volume":"36","author":"Koenders","year":"2015","journal-title":"Trends Pharmacol Sci"},{"key":"B96","doi-asserted-by":"publisher","first-page":"50","DOI":"10.3969\/j.issn.1671-6450.2022.01.010","article-title":"Correlation of serum activin A and irisin levels with disease activity, bone mineral density and skeletal muscle mass in patients with rheumatoid arthritis","volume":"21","author":"Shan","year":"2022","journal-title":"J Doubtful Diseases."},{"key":"B97","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.sleep.2019.10.021","article-title":"Preliminary study of the association of serum irisin levels with poor sleep quality in rheumatoid arthritis patients","volume":"67","author":"Gamal","year":"2020","journal-title":"Sleep Med"},{"key":"B98","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1080\/13510002.2022.2031516","article-title":"The emerging role of irisin in experimentally induced arthritis: a recent update involving HMGB1\/MCP1\/Chitotriosidase I-mediated necroptosis","volume":"27","author":"Raafat Ibrahim","year":"2022","journal-title":"Redox Rep Commun Free Radical Res"},{"key":"B99","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.2741\/4273","article-title":"Fracture healing: from basic science to role of nutrition","volume":"19","author":"Giganti","year":"2014","journal-title":"Front bioscience (Landmark edition)."},{"key":"B100","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.jbspin.2017.03.011","article-title":"Low serum concentrations of Irisin are associated with increased risk of hip fracture in Chinese older women","volume":"85","author":"Yan","year":"2018","journal-title":"Joint Bone spine."},{"key":"B101","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.3760\/j.issn.1673-4777.2022.08.023","article-title":"Relationship between serum irisin and hydrogen sulfide levels and fracture healing after internal fixation with compression plates in elderly patients with femoral stem fractures","volume":"17","author":"Yu","year":"2022","journal-title":"Chin Med"},{"key":"B102","doi-asserted-by":"publisher","first-page":"4278","DOI":"10.12659\/msm.906293","article-title":"The irisin hormone profile and expression in human bone tissue in the bone healing process in patients","volume":"23","author":"Serbest","year":"2017","journal-title":"Med Sci monitor Int Med J Exp Clin Res"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.3390\/ijms221910863","article-title":"Systemic administration of recombinant irisin accelerates fracture healing in mice","volume":"22","author":"Colucci","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24031809","article-title":"Irisin modulates inflammatory, angiogenic, and osteogenic factors during fracture healing","volume":"24","author":"Oranger","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B105","doi-asserted-by":"publisher","first-page":"732","DOI":"10.3977\/j.issn.1005-8478.2022.08.12","article-title":"Effect of Iris and in vitro shock waves on fracture healing in devitalized rats","volume":"30","author":"Heqiu","year":"2022","journal-title":"Chin J Orthopaedic Surgery."},{"key":"B106","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1111\/pin.13080","article-title":"Translational cell biology of highly malignant osteosarcoma","volume":"71","author":"Roessner","year":"2021","journal-title":"Pathol Int"},{"key":"B107","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1002\/cncr.24121","article-title":"Osteosarcoma incidence and survival rates from 1973 to 2004: data from the Sur-veillance, Epidemiology, and End Results Program","volume":"115","author":"Mirabello","year":"2009","journal-title":"Cancer."},{"key":"B108","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.bone.2016.10.017","article-title":"Molecular genetics of osteosarcoma","volume":"102","author":"Rickel","year":"2017","journal-title":"Bone."},{"key":"B109","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/978-3-319-07323-1_4","article-title":"Osteosarcoma","volume":"162","author":"Moore","year":"2014","journal-title":"Cancer Treat Res"},{"key":"B110","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1089\/cbr.2019.2933","article-title":"The effects of miR-214-3p and Irisin\/FNDC5 on the biological behavior of osteosarcoma cells","volume":"35","author":"Cheng","year":"2020","journal-title":"Cancer biotherapy radiopharmaceuticals."},{"key":"B111","doi-asserted-by":"publisher","first-page":"2647","DOI":"10.3892\/or.2017.5973","article-title":"Irisin reverses the IL-6 induced epithe-lial-mesenchymal transition in osteosarcoma cell migration and invasion through the STAT3\/Snail signaling pathway","volume":"38","author":"Kong","year":"2017","journal-title":"On-cology Rep"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2023.1212892\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T12:21:52Z","timestamp":1691151712000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2023.1212892\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,4]]},"references-count":111,"alternative-id":["10.3389\/fendo.2023.1212892"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2023.1212892","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,4]]},"article-number":"1212892"}}