{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:13:08Z","timestamp":1793383988211,"version":"4.5.0"},"reference-count":71,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-153055, FRN-167027"],"award-info":[{"award-number":["PJT-153055, FRN-167027"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>\n                    Preeclampsia (PE), a hypertensive pregnancy disorder, can originate from varied etiology. Placenta malperfusion has long been considered the primary cause of PE. However, we and others have showed that this disorder can also result from heightened inflammation at the maternal-fetal interface. To advance our understanding of this understudied PE subtype, it is important to establish validated rodent models to study the pathophysiology and test therapies. We evaluated three previously described approaches to induce inflammation-mediated PE-like features in pregnant rats: 1) Tumor necrosis factor-\u03b1 (TNF-\u03b1) infusion via osmotic pump from gestational day (GD) 14-19 at 50ng\/day\/animal; 2) Polyinosinic:polycytidylic acid (Poly I:C) intraperitoneal (IP) injections from GD 10-18 (alternate days) at 10mg\/kg\/day\/animal; and, 3) Lipopolysaccharide (LPS) IP injections from GD 13-18 at 20ug-70ug\/kg\/day per animal. Maternal blood pressure was measured by tail-cuff. Upon sacrifice, fetal and placenta weights were recorded. Placenta histomorphology was assessed using H&amp;amp;E sections. Placenta inflammation was determined by quantifying TNF-\u03b1 levels and inflammatory gene expression. Placenta metabolic and mitochondrial health were determined by measuring mitochondrial respiration rates and placenta NAD\n                    <jats:sup>+<\/jats:sup>\n                    \/NADH content. Of the three rodent models tested, we found that Poly I:C and LPS decreased both fetal weight and survival; and correlated with a reduction in region specific placenta growth. As the least effective model characterized, TNF-\u03b1 treatment resulted in a subtle decrease in fetal\/placenta weight and placenta mitochondrial respiration. Only the LPS model was able to induce maternal hypertension and exhibited pronounced placenta metabolic and mitochondrial dysfunction, common features of PE. Thus, the rat LPS model was most effective for recapitulating features observed in cases of human inflammatory PE. Future mechanistic and\/or therapeutic intervention studies focuses on this distinct PE patient population may benefit from the employment of this rodent model of PE.\n                  <\/jats:p>","DOI":"10.3389\/fendo.2023.1219205","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:47:15Z","timestamp":1695948435000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["A comparison of rat models that best mimic immune-driven preeclampsia in humans"],"prefix":"10.3389","volume":"14","author":[{"given":"Fahmida","family":"Jahan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goutham","family":"Vasam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusmaris","family":"Cariaco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abolfazl","family":"Nik-Akhtar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keir J.","family":"Menzies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon A.","family":"Bainbridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,9,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.07293","article-title":"Unsupervised placental gene expression profiling identifies clinically relevant subclasses of human preeclampsia","volume":"68","author":"Leavey","year":"2016","journal-title":"Hypertension"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1081\/PRG-120021060","article-title":"Subclassification of preeclampsia","volume":"22","author":"von Dadelszen","year":"2003","journal-title":"Hypertens Pregnancy"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2013.12.008","article-title":"IFPA Senior Award Lecture: making sense of pre-eclampsia - two placental causes of preeclampsia","author":"Redman","year":"2014","journal-title":"Placenta"},{"key":"B4","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s11906-015-0595-4","article-title":"Preeclampsia: syndrome or disease","volume":"17","author":"Myatt","year":"2015","journal-title":"Curr Hypertens Rep"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.112.191213","article-title":"Low placental growth factor across pregnancy identifies a subset of women with preterm preeclampsia: type 1 versus type 2 preeclampsia","volume":"60","author":"Powers","year":"2012","journal-title":"Hypertension"},{"key":"B6","doi-asserted-by":"publisher","first-page":"604 e1","DOI":"10.1016\/j.ajog.2018.09.036","article-title":"The clinical heterogeneity of preeclampsia is related to both placental gene expression and placental histopathology","volume":"219","author":"Benton","year":"2018","journal-title":"Am J Obstet Gynecol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"e0116508","DOI":"10.1371\/journal.pone.0116508","article-title":"Large scale aggregate microarray analysis reveals three distinct molecular subclasses of human preeclampsia","volume":"10","author":"Leavey","year":"2015","journal-title":"PloS One"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.14781","article-title":"Subtypes of preeclampsia: recognition and determining clinical usefulness","volume":"77","author":"Roberts","year":"2021","journal-title":"Hypertension"},{"key":"B9","doi-asserted-by":"crossref","first-page":"488 e1","DOI":"10.1016\/j.ajog.2019.01.220","article-title":"Circulating microparticle proteins obtained in the late first trimester predict spontaneous preterm birth at less than 35 weeks\u2019 gestation: a panel validation with specific characterization by parity","volume":"220","author":"McElrath","year":"2019","journal-title":"Am J Obstet Gynecol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2019.06.384","article-title":"Both \u201ccanonical\u201d and \u201cimmunological\u201d preeclampsia subtypes demonstrate changes in placental immune cell composition","volume":"83","author":"Leavey","year":"2019","journal-title":"Placenta"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.11.005","article-title":"Placental energy metabolism in health and disease-significance of development and implications for preeclampsia","volume":"226","author":"Aye","year":"2022","journal-title":"Am J Obstet Gynecol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"165967","DOI":"10.1016\/j.bbadis.2020.165967","article-title":"Placental mitochondrial dysfunction with metabolic diseases: Therapeutic approaches","volume":"1867","author":"Hebert","year":"2021","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24044177","article-title":"Placental mitochondrial function and dysfunction in preeclampsia","volume":"24","author":"Jahan","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B14","doi-asserted-by":"publisher","first-page":"e12","DOI":"10.1016\/j.placenta.2021.07.040","article-title":"PARP mediated NAD+ depletion and Placental Dysfunction in Preeclampsia","volume":"112","author":"Jahan","year":"2021","journal-title":"Placenta"},{"key":"B15","doi-asserted-by":"publisher","first-page":"101195","DOI":"10.1016\/j.molmet.2021.101195","article-title":"Role of NAD(+) in regulating cellular and metabolic signaling pathways","volume":"49","author":"Amjad","year":"2021","journal-title":"Mol Metab"},{"key":"B16","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s40169-016-0104-7","article-title":"Emerging therapeutic roles for NAD(+) metabolism in mitochondrial and age-related disorders","volume":"5","author":"Srivastava","year":"2016","journal-title":"Clin Transl Med"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.02.011","article-title":"Therapeutic potential of NAD-boosting molecules: the in vivo evidence","volume":"27","author":"Rajman","year":"2018","journal-title":"Cell Metab"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.59828","article-title":"Instability in NAD(+) metabolism leads to impaired cardiac mitochondrial function and communication","volume":"10","author":"Lauritzen","year":"2021","journal-title":"Elife"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.765477","article-title":"Intracellular NAD(+) depletion confers a priming signal for NLRP3 inflammasome activation","volume":"12","author":"Shim","year":"2021","journal-title":"Front Immunol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2211310119","article-title":"NAD(+) metabolism drives astrocyte proinflammatory reprogramming in central nervous system autoimmunity","volume":"119","author":"Meyer","year":"2022","journal-title":"Proc Natl Acad Sci U.S.A."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izac247.013","article-title":"NAD+ Depletion in the intestinal epithelium results in mitochondrial dysfunction and influences the pathogenesis of experimental colitis","volume":"29","author":"Novak","year":"2023","journal-title":"Inflammatory Bowel Dis"},{"key":"B22","doi-asserted-by":"publisher","first-page":"107846","DOI":"10.1016\/j.intimp.2021.107846","article-title":"Protective effect and mechanism of nicotinamide adenine dinucleotide against optic neuritis in mice with experimental autoimmune encephalomyelitis","volume":"98","author":"Guo","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.08.024","article-title":"Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease","volume":"66","author":"Gariani","year":"2017","journal-title":"J Hepatol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqac096","article-title":"Animal models of preeclampsia: mechanistic insights and promising therapeutics","volume":"163","author":"Taylor","year":"2022","journal-title":"Endocrinology"},{"key":"B25","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1007\/s11906-016-0633-x","article-title":"Placental ischemia and resultant phenotype in animal models of preeclampsia","volume":"18","author":"LaMarca","year":"2016","journal-title":"Curr Hypertens Rep"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1992.tb00735.x","article-title":"Sera from preeclamptic women specifically activate human umbilical vein endothelial cells in vitro: morphological and biochemical evidence","volume":"27","author":"Roberts","year":"1992","journal-title":"Am J Reprod Immunol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"e0157584","DOI":"10.1371\/journal.pone.0157584","article-title":"Association between placental lesions, cytokines and angiogenic factors in pregnant women with preeclampsia","volume":"11","author":"Weel","year":"2016","journal-title":"PloS One"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1997.tb00222.x","article-title":"Placental cytokines and the pathogenesis of preeclampsia","volume":"37","author":"Conrad","year":"1997","journal-title":"Am J Reprod Immunol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(01)02255-5","article-title":"Tumor necrosis factor-alpha-induced hypertension in pregnant rats results in decreased renal neuronal nitric oxide synthase expression","volume":"15","author":"Alexander","year":"2002","journal-title":"Am J Hypertens"},{"key":"B30","doi-asserted-by":"publisher","first-page":"e41884","DOI":"10.1371\/journal.pone.0041884","article-title":"Placental Toll-like receptor 3 and Toll-like receptor 7\/8 activation contributes to preeclampsia in humans and mice","volume":"7","author":"Chatterjee","year":"2012","journal-title":"PloS One"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2012.01167.x","article-title":"Sensing of microbial molecular patterns by Toll-like receptors","volume":"250","author":"Song","year":"2012","journal-title":"Immunol Rev"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20130295","article-title":"Inflammation in rat pregnancy inhibits spiral artery remodeling leading to fetal growth restriction and features of preeclampsia","volume":"211","author":"Cotechini","year":"2014","journal-title":"J Exp Med"},{"key":"B33","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1111\/j.1600-0897.1996.tb00141.x","article-title":"Effects of tumor necrosis factor-alpha on human trophoblast cell adhesion and motility","volume":"36","author":"Todt","year":"1996","journal-title":"Am J Reprod Immunol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.104.038000","article-title":"Activated macrophages inhibit human cytotrophoblast invasiveness in vitro","volume":"73","author":"Renaud","year":"2005","journal-title":"Biol Reprod"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12501","article-title":"Protective effect of metformin on a rat model of lipopolysaccharide-induced preeclampsia","volume":"33","author":"Hu","year":"2019","journal-title":"Fundam Clin Pharmacol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"e0124001","DOI":"10.1371\/journal.pone.0124001","article-title":"Single administration of ultra-low-dose lipopolysaccharide in rat early pregnancy induces TLR4 activation in the placenta contributing to preeclampsia","volume":"10","author":"Xue","year":"2015","journal-title":"PloS One"},{"key":"B37","article-title":"Glomerular inflammation in pregnant rats after infusion of low dose endotoxin. An immunohistological study in experimental pre-eclampsia","volume":"147","author":"Faas","year":"1995","journal-title":"Am J Pathol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(94)90463-4","article-title":"A new animal model for human preeclampsia: ultra-low-dose endotoxin infusion in pregnant rats","volume":"171","author":"Faas","year":"1994","journal-title":"Am J Obstet Gynecol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2009.185","article-title":"Toll-like receptor 3 activation during pregnancy elicits preeclampsia-like symptoms in rats","volume":"22","author":"Tinsley","year":"2009","journal-title":"Am J Hypertens"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpu100","article-title":"Cotreatment with interleukin 4 and interleukin 10 modulates immune cells and prevents hypertension in pregnant mice","volume":"28","author":"Chatterjee","year":"2015","journal-title":"Am J Hypertens"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1177\/0192623315570339","article-title":"Vaginal cytology of the laboratory rat and mouse: review and criteria for the staging of the estrous cycle using stained vaginal smears","volume":"43","author":"Cora","year":"2015","journal-title":"Toxicol Pathol"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000169152.59854.36","article-title":"Role of endothelin in mediating tumor necrosis factor-induced hypertension in pregnant rats","volume":"46","author":"LaMarca","year":"2005","journal-title":"Hypertension"},{"key":"B43","first-page":"e51914","article-title":"A radio-telemetric system to monitor cardiovascular function in rats with spinal cord transection and embryonic neural stem cell grafts","author":"Hou","year":"2014","journal-title":"J Vis Exp"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.34639","article-title":"CD68+ macrophages as crucial components of the foreign body reaction demonstrate an unconventional pattern of functional markers quantified by analysis with double fluorescence staining","volume":"108","author":"Klinge","year":"2020","journal-title":"J BioMed Mater Res B Appl Biomater"},{"key":"B45","doi-asserted-by":"publisher","first-page":"16878","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: Open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci Rep"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2005.07.008","article-title":"ICAM-1 is overexpressed by villous trophoblasts in placentitis","volume":"27","author":"Juliano","year":"2006","journal-title":"Placenta"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/nri3070","article-title":"Monocyte recruitment during infection and inflammation","volume":"11","author":"Shi","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.151860b","article-title":"Endothelial-dependent mechanisms of leukocyte recruitment to the vascular wall","volume":"101","author":"Rao","year":"2007","journal-title":"Circ Res"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.2MR0220-549R","article-title":"ICAM-1: A master regulator of cellular responses in inflammation, injury resolution, and tumorigenesis","volume":"108","author":"Bui","year":"2020","journal-title":"J Leukoc Biol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ17-0363","article-title":"Placental growth factor (PlGF) is linked to inflammation and metabolic disorders in mice with diet-induced obesity","volume":"65","author":"Kang","year":"2018","journal-title":"Endocr J"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228714","article-title":"PlGF immunological impact during pregnancy","volume":"21","author":"Albonici","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20153695","article-title":"Role of the monocyte-macrophage system in normal pregnancy and preeclampsia","volume":"20","author":"Vishnyakova","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.478","article-title":"Organelle isolation: functional mitochondria from mouse liver, muscle and cultured fibroblasts","volume":"2","author":"Frezza","year":"2007","journal-title":"Nat Protoc"},{"key":"B54","doi-asserted-by":"publisher","first-page":"e0190213","DOI":"10.1371\/journal.pone.0190213","article-title":"General anesthetics cause mitochondrial dysfunction and reduction of intracellular ATP levels","volume":"13","author":"Kishikawa","year":"2018","journal-title":"PloS One"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.61","article-title":"Analysis of mitochondrial function in situ in permeabilized muscle fibers, tissues and cells","volume":"3","author":"Kuznetsov","year":"2008","journal-title":"Nat Protoc"},{"key":"B56","article-title":"Hypertension in pregnancy. Report of the american college of obstetricians and gynecologists\u2019 Task force on hypertension in pregnancy","volume":"122","year":"2013","journal-title":"Obstet Gynecol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00491","article-title":"Central inhibition of tumor necrosis factor alpha reduces hypertension by attenuating oxidative stress in the rostral ventrolateral medulla in renovascular hypertensive rats","volume":"10","author":"Carvalho-Galvao","year":"2019","journal-title":"Front Physiol"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0001292022","article-title":"IFN-gamma contributes to the immune mechanisms of hypertension","volume":"3","author":"Benson","year":"2022","journal-title":"Kidney"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.3390\/biology10101041","article-title":"Nitric oxide as a central molecule in hypertension: focus on the vasorelaxant activity of new nitric oxide donors","volume":"10","author":"da Silva","year":"2021","journal-title":"Biol (Basel)"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2006.00455.x","article-title":"Tumor necrosis factor-alpha in gestation and puerperium of women with gestational hypertension and pre-eclampsia","volume":"57","author":"Peracoli","year":"2007","journal-title":"Am J Reprod Immunol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"23841","DOI":"10.1038\/s41598-021-03216-9","article-title":"Distinct trans-placental effects of maternal immune activation by TLR3 and TLR7 agonists: implications for schizophrenia risk","volume":"11","author":"Kwon","year":"2021","journal-title":"Sci Rep"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00570","article-title":"Regulation of placental development and its impact on fetal growth-new insights from mouse models","volume":"9","author":"Woods","year":"2018","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2011.11.011","article-title":"Impact of genetic background on placental glycogen storage in mice","volume":"33","author":"Tunster","year":"2012","journal-title":"Placenta"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.mod.2004.05.017","article-title":"Placental growth retardation due to loss of imprinting of Phlda2","volume":"121","author":"Salas","year":"2004","journal-title":"Mech Dev"},{"key":"B65","doi-asserted-by":"publisher","first-page":"10871","DOI":"10.1038\/srep10871","article-title":"Vitamin D3 inhibits lipopolysaccharide-induced placental inflammation through reinforcing interaction between vitamin D receptor and nuclear factor kappa B p65 subunit","volume":"5","author":"Chen","year":"2015","journal-title":"Sci Rep"},{"key":"B66","doi-asserted-by":"publisher","first-page":"e82713","DOI":"10.1371\/journal.pone.0082713","article-title":"Folic acid protects against lipopolysaccharide-induced preterm delivery and intrauterine growth restriction through its anti-inflammatory effect in mice","volume":"8","author":"Zhao","year":"2013","journal-title":"PloS One"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.14807","article-title":"Fibrinogen-like protein 2-associated transcriptional and histopathological features of immunological preeclampsia","volume":"76","author":"Robineau-Charette","year":"2020","journal-title":"Hypertension"},{"key":"B68","doi-asserted-by":"publisher","first-page":"10262","DOI":"10.1038\/s41598-022-14248-0","article-title":"Mid-pregnancy poly(I:C) viral mimic disrupts placental ABC transporter expression and leads to long-term offspring motor and cognitive dysfunction","volume":"12","author":"Monteiro","year":"2022","journal-title":"Sci Rep"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.706499","article-title":"Effect of sublethal prenatal endotoxaemia on murine placental transport systems and lipid homeostasis","volume":"12","author":"Reginatto","year":"2021","journal-title":"Front Microbiol"},{"key":"B70","doi-asserted-by":"publisher","first-page":"11488","DOI":"10.1038\/s41598-019-47865-3","article-title":"Dysregulation of placental ABC transporters in a murine model of malaria-induced preterm labor","volume":"9","author":"Fontes","year":"2019","journal-title":"Sci Rep"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.06.008","article-title":"The therapeutic promises of NAD(+) boosters","volume":"33","author":"Montllor-Albalate","year":"2021","journal-title":"Cell Metab"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2023.1219205\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:47:20Z","timestamp":1695948440000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2023.1219205\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,28]]},"references-count":71,"alternative-id":["10.3389\/fendo.2023.1219205"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2023.1219205","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,28]]},"article-number":"1219205"}}