{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:13:48Z","timestamp":1780445628507,"version":"3.54.1"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004775","name":"Natural Science Foundation of Gansu Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016321","name":"First Clinical Medical School, Lanzhou University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Polycystic ovary syndrome (PCOS) is a common endocrinopathy causing infertility in childbearing women. Progestin-primed ovarian stimulation (PPOS) protocol has recently been used for infertile women. However, whether PPOS provides a significant benefit over gonadotropin-releasing hormone (GnRH) analogue protocols in PCOS is still controversial. The objective of this systematic review is to investigate the efficacy of PPOS in patients with PCOS during <jats:italic>in vitro<\/jats:italic> fertilization (IVF) or intracytoplasmic sperm injection (ICSI). We searched Medline, Embase, Google Scholar, ClinicalTrials, and Cochrane Central Register of Controlled Trials from inception to April 1, 2023. Randomized controlled trials (RCTs) and observational studies comparing the efficacy between PPOS and conventional GnRH analogue protocols in patients with PCOS in English were included. The primary outcomes included live birth rate, the incidence of moderate or severe ovarian hyperstimulation syndrome (OHSS), and the number of metaphase II oocytes. The pooled estimates were calculated using the random-effects models as odds ratios (OR) or mean differences (MD) with 95% confidence intervals (CIs). Three RCTs and six cohort studies involving 2289 patients were included. Results from RCTs suggest that PPOS leads to no significant difference in the risk of OHSS, the number of metaphase II oocytes, or the rate of live birth when compared to GnRH analogue protocols. The pooling estimates of cohort studies showed consistent results. Additionally, in cohort studies, PPOS required a higher dose of Gn and tended to improve the implantation rate, clinical pregnancy rate, and ongoing pregnancy rate. For subgroup analyses, the higher implantation rate, clinical pregnancy rate, and ongoing pregnancy rate were found in PPOS compared to the GnRH agonist short protocol. However, the certainty of the evidence for the outcomes was generally low. Overall, There is currently no evidence to support that PPOS could reduce the risk of OHSS, increase oocyte maturation, or improve pregnancy outcomes in women with PCOS undergoing IVF\/ICSI when compared to GnRH analogue protocols. Considering its efficiency and safety, this protocol could be a patient-friendly and viable alternative for PCOS patients, especially when frozen-thawed embryo transfer is planned. Future high-quality randomized trials with children\u2019s long-term safety and cost-effective analyses are still required.<\/jats:p><jats:sec><jats:title>System Review Registration<\/jats:title><jats:p>NPLASY (202340059). <jats:ext-link>https:\/\/inplasy.com\/inplasy-2023-4-0059\/<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2023.1224858","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T04:52:11Z","timestamp":1695185531000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Efficacy of progestin-primed ovarian stimulation in women with polycystic ovary syndrome undergoing in vitro fertilization: a systematic review and meta-analysis"],"prefix":"10.3389","volume":"14","author":[{"given":"Liu","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuxiang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xufei","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,9,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem426","article-title":"Consensus on infertility treatment related to polycystic ovary syndrome","volume":"23","author":"Legro","year":"2008","journal-title":"Hum Reprod (Oxford England)"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/s0015-0282(16)56287-6","article-title":"In vitro fertilization and embryo transfer for the treatment of infertility associated with polycystic ovary syndrome","volume":"60","author":"Homburg","year":"1993","journal-title":"Fertility sterility"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a138260","article-title":"The ovarian hyperstimulation syndrome in in-vitro fertilization: A belgian multicentric study. I. Clinical and biological features","volume":"8","author":"Delvigne","year":"1993","journal-title":"Hum Reprod (Oxford England)"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.05.004","article-title":"Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome","volume":"110","author":"Teede","year":"2018","journal-title":"Fertility sterility"},{"key":"B5","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.rbmo.2011.09.017","article-title":"Meta-analysis of gnrh antagonist protocols: do they reduce the risk of Ohss in Pcos","volume":"24","author":"Pundir","year":"2012","journal-title":"Reprod biomed Online"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmx017","article-title":"Gnrh antagonist versus long agonist protocols in ivf: A systematic review and meta-analysis accounting for patient type","volume":"23","author":"Lambalk","year":"2017","journal-title":"Hum Reprod Update"},{"key":"B7","doi-asserted-by":"publisher","first-page":"48","DOI":"10.4274\/jtgga.2016.0107","article-title":"Pharmacokinetic, pharmacodynamic, and clinical aspects of ovulation induction agents: A review of the literature","volume":"18","author":"Kahyao\u011flu","year":"2017","journal-title":"J Turkish German Gynecol Assoc"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.09.007","article-title":"Luteal-phase ovarian stimulation is feasible for producing competent oocytes in women undergoing in vitro fertilization\/intracytoplasmic sperm injection treatment, with optimal pregnancy outcomes in frozen-thawed embryo transfer cycles","volume":"101","author":"Kuang","year":"2014","journal-title":"Fertility sterility"},{"key":"B9","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.fertnstert.2015.03.022","article-title":"Medroxyprogesterone acetate is an effective oral alternative for preventing premature luteinizing hormone surges in women undergoing controlled ovarian hyperstimulation for in vitro fertilization","volume":"104","author":"Kuang","year":"2015","journal-title":"Fertility sterility"},{"key":"B10","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s12958-017-0291-0","article-title":"Controlled ovulation of the dominant follicle using progestin in minimal stimulation in poor responders","volume":"15","author":"Chen","year":"2017","journal-title":"Reprod Biol endocrinol: RB&E"},{"key":"B11","doi-asserted-by":"publisher","first-page":"e4193","DOI":"10.1097\/md.0000000000004193","article-title":"The utrogestan and hmg protocol in patients with polycystic ovarian syndrome undergoing controlled ovarian hyperstimulation during ivf\/icsi treatments","volume":"95","author":"Zhu","year":"2016","journal-title":"Medicine"},{"key":"B12","doi-asserted-by":"publisher","first-page":"11927","DOI":"10.1038\/s41598-017-12151-7","article-title":"Use of medroxyprogesterone acetate in women with ovarian endometriosis undergoing controlled ovarian hyperstimulation for in vitro fertilization","volume":"7","author":"Guo","year":"2017","journal-title":"Sci Rep"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmw047","article-title":"New stimulation regimens: endogenous and exogenous progesterone use to block the lh surge during ovarian stimulation for ivf","volume":"23","author":"Massin","year":"2017","journal-title":"Hum Reprod Update"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der251","article-title":"An ohss-free clinic by segmentation of ivf treatment","volume":"26","author":"Devroey","year":"2011","journal-title":"Hum Reprod (Oxford England)"},{"key":"B15","doi-asserted-by":"publisher","first-page":"e2939","DOI":"10.1097\/md.0000000000002939","article-title":"Controlled ovarian stimulation using medroxyprogesterone acetate and hmg in patients with polycystic ovary syndrome treated for ivf: A double-blind randomized crossover clinical trial","volume":"95","author":"Wang","year":"2016","journal-title":"Medicine"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.18502\/ijrm.v17i9.5103","article-title":"Progesterone-primed ovarian stimulation in polycystic ovarian syndrome: an Rct","volume":"17","author":"Eftekhar","year":"2019","journal-title":"Int J Reprod biomed"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.744968","article-title":"Luteinizing hormone suppression by progestin-primed ovarian stimulation is associated with higher implantation rate for patients with polycystic ovary syndrome who underwent in vitro fertilization\/intracytoplasmic sperm injection cycles: comparing with short protocol","volume":"12","author":"Chen","year":"2021","journal-title":"Front Physiol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.Ed000142","article-title":"Updated guidance for trusted systematic reviews: A new edition of the cochrane handbook for systematic reviews of interventions","volume":"10","author":"Cumpston","year":"2019","journal-title":"Cochrane Database systematic Rev"},{"key":"B19","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/s13643-021-01626-4","article-title":"The prisma 2020 statement: an updated guideline for reporting systematic reviews","volume":"10","author":"Page","year":"2021","journal-title":"Systematic Rev"},{"key":"B20","article-title":"Chapter 8: assessing Risk of Bias in Included Studies","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.2.0 (Updated June 2017)","author":"Higgins","year":"2017"},{"key":"B21","article-title":"The Newcastle-Ottawa scale (NOS) for assessing the quality of non-randomized studies in meta-analyses","volume-title":"Applied Engineering in Agriculture","author":"Wells","year":"2000"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.25.14956","article-title":"Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome","volume":"95","author":"Legro","year":"1998","journal-title":"Proc Natl Acad Sci United States America"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2021.11.026","article-title":"Grade guidance 24 optimizing the integration of randomized and non-randomized studies of interventions in evidence syntheses and health guidelines","volume":"142","author":"Cuello-Garcia","year":"2022","journal-title":"J Clin Epidemiol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurox.2019.100060","article-title":"Polycystic ovary syndrome (Pcos) and genetic predisposition: A review article","volume":"3","author":"Ajmal","year":"2019","journal-title":"Eur J obstetrics gynecol Reprod biol: X"},{"key":"B25","doi-asserted-by":"publisher","first-page":"e27943","DOI":"10.7759\/cureus.27943","article-title":"Polycystic ovarian syndrome: prevalence, predisposing factors, and awareness among adolescent and young girls of south India","volume":"14","author":"Jabeen","year":"2022","journal-title":"Cureus"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.11.015","article-title":"Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health","volume":"103","author":"Dumesic","year":"2015","journal-title":"Fertility sterility"},{"key":"B27","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 6.3 (Updated February 2022)","author":"Higgins","year":"2022"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1002\/sim.698","article-title":"A comparison of methods to detect publication bias in meta-analysis","volume":"20","author":"Macaskill","year":"2001","journal-title":"Stat Med"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1111\/jog.14267","article-title":"Dydrogesterone-primed ovarian stimulation is an effective alternative to gonadotropin-releasing hormone antagonist protocol for freeze-all cycles in polycystic ovary syndrome","volume":"46","author":"Gurbuz","year":"2020","journal-title":"J obstetrics gynaecol Res"},{"key":"B30","doi-asserted-by":"publisher","first-page":"22732","DOI":"10.1038\/s41598-021-02227-w","article-title":"Progestin primed ovarian stimulation using corifollitropin alfa in pcos women effectively prevents lh surge and reduces injection burden compared to gnrh antagonist protocol","volume":"11","author":"Huang","year":"2021","journal-title":"Sci Rep"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0751-5","article-title":"Using human genetics to understand the disease impacts of testosterone in men and women","volume":"26","author":"Ruth","year":"2020","journal-title":"Nat Med"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-019-2055-x","article-title":"Flexible gnrh antagonist protocol versus progestin-primed ovarian stimulation (Ppos) protocol in patients with polycystic ovary syndrome: comparison of clinical outcomes and ovarian response","volume":"39","author":"Xiao","year":"2019","journal-title":"Curr Med Sci"},{"key":"B33","doi-asserted-by":"publisher","first-page":"387","DOI":"10.21037\/atm-20-1592","article-title":"Progesterone protocol versus gonadotropin-releasing hormone antagonist protocol in women with polycystic ovarian syndrome undergoing in vitro fertilization treatments with frozen-thawed embryo transfer: A prospective randomized controlled trial","volume":"9","author":"Zhu","year":"2021","journal-title":"Ann Trans Med"},{"key":"B34","first-page":"860","article-title":"Comparison of progestin-primed ovarian stimulation and GnRH antagonist protocol in clinical outcome for PCOS patients","volume":"114","author":"Li","year":"2020","journal-title":"ASRM Abstracts"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/8.6.559","article-title":"Epidemiology and prevention of ovarian hyperstimulation syndrome (Ohss): A review","volume":"8","author":"Delvigne","year":"2002","journal-title":"Hum Reprod Update"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.08.048","article-title":"Prevention and treatment of moderate and severe ovarian hyperstimulation syndrome: A guideline","volume":"106","author":"Pfeifer","year":"2016","journal-title":"Fertility sterility"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1093\/humrep\/dew149","article-title":"Ovarian hyperstimulation syndrome: review and new classification criteria for reporting in clinical trials","volume":"31","author":"Humaidan","year":"2016","journal-title":"Hum Reprod (Oxford England)"},{"key":"B38","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/s0039-128x(85)80006-4","article-title":"Progestin regulation of progesterone biosynthetic enzymes in cultured rat granulosa cells","volume":"46","author":"Ruiz de Galarreta","year":"1985","journal-title":"Steroids"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod30.4.903","article-title":"Estrogen regulation of progestin biosynthetic enzymes in cultured rat granulosa cells","volume":"30","author":"Fanjul","year":"1984","journal-title":"Biol Reprod"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex010","article-title":"Fsh stimulation promotes progesterone synthesis and output from human granulosa cells without luteinization","volume":"32","author":"Oktem","year":"2017","journal-title":"Hum Reprod (Oxford England)"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/s0015-0282(16)55968-8","article-title":"Luteinizing hormone: its role, mechanism of action, and detrimental effects when hypersecreted during the follicular phase","volume":"59","author":"Shoham","year":"1993","journal-title":"Fertility sterility"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmn015","article-title":"Follicle dynamics and anovulation in polycystic ovary syndrome","volume":"14","author":"Franks","year":"2008","journal-title":"Hum Reprod Update"},{"key":"B43","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1093\/humupd\/dmq032","article-title":"Extra- and intra-ovarian factors in polycystic ovary syndrome: impact on oocyte maturation and embryo developmental competence","volume":"17","author":"Qiao","year":"2011","journal-title":"Hum Reprod Update"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-58-2-378","article-title":"Progesterone modulation of pulsatile luteinizing hormone secretion in normal women","volume":"58","author":"Soules","year":"1984","journal-title":"J Clin Endocrinol Metab"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod67.1.119","article-title":"Progesterone blocks the estradiol-stimulated luteinizing hormone surge by disrupting activation in response to a stimulatory estradiol signal in the ewe","volume":"67","author":"Richter","year":"2002","journal-title":"Biol Reprod"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.103.023390","article-title":"Progesterone Promotes Oocyte Maturation, but Not Ovulation, in Nonhuman Primate Follicles without a Gonadotropin Surge","volume":"71","author":"Borman","year":"2004","journal-title":"Biol Reprod"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.1080270209","article-title":"Relationships between follicular fluid steroid hormone concentrations, oocyte maturity, in vitro fertilization and embryonic development in the rhesus monkey","volume":"27","author":"Morgan","year":"1990","journal-title":"Mol Reprod Dev"},{"key":"B48","doi-asserted-by":"publisher","first-page":"4456","DOI":"10.1038\/s41598-022-08400-z","article-title":"Conventional gnrh antagonist protocols versus long gnrh agonist protocol in ivf\/icsi cycles of polycystic ovary syndrome women: A systematic review and meta-analysis","volume":"12","author":"Kadoura","year":"2022","journal-title":"Sci Rep"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew051","article-title":"Risk of severe ovarian hyperstimulation syndrome in gnrh antagonist versus gnrh agonist protocol: rct including 1050 first ivf\/icsi cycles","volume":"31","author":"Toftager","year":"2016","journal-title":"Hum Reprod (Oxford England)"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.01.163","article-title":"Ovarian hyperstimulation syndrome prevention by gonadotropin-releasing hormone agonist triggering of final oocyte maturation in a gonadotropin-releasing hormone antagonist protocol in combination with a \u201cFreeze-all\u201d Strategy: A prospective multicentric study","volume":"95","author":"Griesinger","year":"2011","journal-title":"Fertility sterility"},{"key":"B51","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1093\/humupd\/dmaa040","article-title":"Progestins for pituitary suppression during ovarian stimulation for art: A comprehensive and systematic review including meta-analyses","volume":"27","author":"Ata","year":"2021","journal-title":"Hum Reprod Update"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2019.03.212","article-title":"Use of progestins to inhibit spontaneous ovulation during ovarian stimulation: the beginning of a new era","volume":"39","author":"La Marca","year":"2019","journal-title":"Reprod biomed Online"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/s0039-128x(00)00121-5","article-title":"Pharmacokinetics of the progesterone-containing vaginal tablet and its use in assisted reproduction","volume":"65","author":"Levy","year":"2000","journal-title":"Steroids"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/s0015-0282(99)00553-1","article-title":"Comparison of the pharmacokinetics of crinone 8% Administered vaginally versus prometrium administered orally in postmenopausal women(3)","volume":"73","author":"Levine","year":"2000","journal-title":"Fertility sterility"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a137138","article-title":"Effects of natural progesterone on the morphology of the endometrium in patients with primary ovarian failure","volume":"5","author":"Bourgain","year":"1990","journal-title":"Hum Reprod (Oxford England)"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deaa068","article-title":"Comparison of euploidy rates of blastocysts in women treated with progestins or gnrh antagonist to prevent the luteinizing hormone surge during ovarian stimulation","volume":"35","author":"La Marca","year":"2020","journal-title":"Hum Reprod (Oxford England)"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.2147\/dddt.S210228","article-title":"Neonatal outcomes and congenital malformations in children born after dydrogesterone application in progestin-primed ovarian stimulation protocol for ivf: A retrospective cohort study","volume":"13","author":"Huang","year":"2019","journal-title":"Drug design Dev Ther"},{"key":"B58","doi-asserted-by":"publisher","first-page":"e11906","DOI":"10.1097\/md.0000000000011906","article-title":"Comparison of neonatal outcomes and live-birth defects after progestin-primed ovarian stimulation versus conventional ovarian stimulation for in vitro fertilization: A large retrospective cohort study","volume":"97","author":"Wang","year":"2018","journal-title":"Medicine"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2018.12.044","article-title":"Evaluation of the cost-effectiveness of ovulation suppression with progestins compared with gnrh analogs in assisted reproduction cycles","volume":"38","author":"Evans","year":"2019","journal-title":"Reprod biomed Online"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1513873","article-title":"Fresh versus frozen embryos for infertility in the polycystic ovary syndrome","volume":"375","author":"Chen","year":"2016","journal-title":"New Engl J Med"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1705334","article-title":"Transfer of fresh versus frozen embryos in ovulatory women","volume":"378","author":"Shi","year":"2018","journal-title":"New Engl J Med"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.702558","article-title":"Progestin-primed ovarian stimulation protocol for patients in assisted reproductive technology: A meta-analysis of randomized controlled trials","volume":"12","author":"Guan","year":"2021","journal-title":"Front Endocrinol"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2023.1224858\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T04:52:16Z","timestamp":1695185536000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2023.1224858\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,19]]},"references-count":62,"alternative-id":["10.3389\/fendo.2023.1224858"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2023.1224858","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,19]]},"article-number":"1224858"}}