{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:02:05Z","timestamp":1764936125939,"version":"3.41.2"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:00:00Z","timestamp":1700006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Backgrounds<\/jats:title><jats:p>The present study was designed to establish and validate a prediction model for high ovarian response (HOR) in the GnRH antagonist protocol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective study, the data of 4160 cycles were analyzed following the <jats:italic>in vitro<\/jats:italic> fertilization (IVF) at our reproductive medical center from June 2018 to May 2022. The cycles were divided into a training cohort (n=3121) and a validation cohort (n=1039) using a random sampling method. Univariate and multivariate logistic regression analyses were used to screen out the risk factors for HOR, and the nomogram was established based on the regression coefficient of the relevant variables. The area under the receiver operating characteristic curve (AUC), the calibration curve, and the decision curve analysis were used to evaluate the performance of the prediction model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multivariate logistic regression analysis revealed that age, body mass index (BMI), follicle-stimulating hormone (FSH), antral follicle count (AFC), and anti-mullerian hormone (AMH) were independent risk factors for HOR (all <jats:italic>P<\/jats:italic>&amp;lt; 0.05). The prediction model for HOR was constructed based on these factors. The AUC of the training cohort was 0.884 (95% CI: 0.869\u20130.899), and the AUC of the validation cohort was 0.884 (95% CI:0.863\u20130.905).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prediction model can predict the probability of high ovarian response prior to IVF treatment, enabling clinicians to better predict the risk of HOR and guide treatment strategies.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2023.1238092","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T09:49:46Z","timestamp":1700041786000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["A prediction model for high ovarian response in the GnRH antagonist protocol"],"prefix":"10.3389","volume":"14","author":[{"given":"Yilin","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenchen","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuilian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,11,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32708-2","article-title":"A Lancet Commission on 70 years of women\u2019s reproductive, maternal, newborn, child, and adolescent health in China","volume":"397","author":"Qiao","year":"2021","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012103.pub2","article-title":"Interventions for the prevention of OHSS in ART cycles: an overview of Cochrane reviews","author":"Mourad","year":"2017","journal-title":"Cochrane Database Systematic Rev"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/bs.vh.2018.01.018","article-title":"The ovarian hyperstimulation syndrome","volume":"107","author":"Blumenfeld","year":"2018","journal-title":"Vitamins Hormones"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.08.048","article-title":"Prevention and treatment of moderate and severe ovarian hyperstimulation syndrome: a guideline","volume":"106","author":"Pfeifer","year":"2016","journal-title":"Fertility Sterility"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-021-02323-w","article-title":"High ovarian response to ovarian stimulation: effect on morphokinetic milestones and cycle outcomes","volume":"38","author":"Schachter-Safrai","year":"2021","journal-title":"J Assist Reprod Genet"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3109\/14647273.2013.795385","article-title":"Controlled ovarian hyperstimulation regimens: a review of the available evidence for clinical practice. 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