{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T23:14:45Z","timestamp":1794093285331,"version":"4.8.0"},"reference-count":238,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:00:00Z","timestamp":1690934400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014764","name":"China International Medical Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014764","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Diabetic kidney disease (DKD) is a chronic complication of diabetes and the leading cause of end-stage renal disease (ESRD) worldwide. Currently, there are limited therapeutic drugs available for DKD. While previous research has primarily focused on glomerular injury, recent studies have increasingly emphasized the role of renal tubular injury in the pathogenesis of DKD. Various factors, including hyperglycemia, lipid accumulation, oxidative stress, hypoxia, RAAS, ER stress, inflammation, EMT and programmed cell death, have been shown to induce renal tubular injury and contribute to the progression of DKD. Additionally, traditional hypoglycemic drugs, anti-inflammation therapies, anti-senescence therapies, mineralocorticoid receptor antagonists, and stem cell therapies have demonstrated their potential to alleviate renal tubular injury in DKD. This review will provide insights into the latest research on the mechanisms and treatments of renal tubular injury in DKD.<\/jats:p>","DOI":"10.3389\/fendo.2023.1238927","type":"journal-article","created":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T08:49:21Z","timestamp":1690966161000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":99,"title":["Tubular injury in diabetic kidney disease: molecular mechanisms and potential therapeutic perspectives"],"prefix":"10.3389","volume":"14","author":[{"given":"Yu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyue","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chak Kwong","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,8,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.11111016","article-title":"Diagnosis and management of type 2 diabetic kidney disease","volume":"12","author":"Doshi","year":"2017","journal-title":"Clin J Am Soc Nephrol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2022.155195","article-title":"Mitochondrial dysfunction in diabetic tubulopathy","volume":"131","author":"Yao","year":"2022","journal-title":"Metabol: Clin Exp"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs260","article-title":"The pathogenic role of the renal proximal tubular cell in diabetic nephropathy","volume":"27","author":"Tang","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2012.09.010","article-title":"Normoalbuminuric diabetic kidney disease in the U.S. Population","volume":"27","author":"Mottl","year":"2013","journal-title":"J Diabetes Complications"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv264","article-title":"New developments concerning the proximal tubule in diabetic nephropathy: in vitro models and mechanisms","volume":"30","author":"Slyne","year":"2015","journal-title":"Nephrol Dial Transplant"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.2217\/bmm-2020-0308","article-title":"Urinary proteins detected using modern proteomics intervene in early type 2 diabetic kidney disease - 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